PMCCPMCCPMCC

Search tips
Search criteria 

Advanced

 
Logo of splusSpringerOpen.comSubmit OnlineRegisterThis journalThis article
 
Springerplus. 2015; 4(Suppl 1): L16.
Published online 2015 June 12. doi:  10.1186/2193-1801-4-S1-L16
PMCID: PMC4797857

Tau regulates the localization and function of End Binding proteins in neuronal cells

Tau is a classical microtubule-associated protein known to regulate microtubule stability in neurons. In our study, we have addressed the putative crosstalk between tau and End binding proteins 1 and 3 (EB1/3), the core microtubule plus-end tracking proteins (+TIPs), in differentiating neuronal cells. We show that tau and EB proteins interact directly and that the cellular distribution and mobility of EB proteins depends on tau localization and expression levels. Moreover, our data reveal that tau is essential for the proper localization of EB1 at the medial-distal region of the axon shaft in developing neurons. In summary, we provide evidence for a new function of tau protein as a direct regulator of EB1/3 proteins. This further indicates that the interplay between classical MAPs and core +TIPs may be important for the fine-tuned regulation of microtubule dynamics and stability during neuronal differentiation.


Articles from SpringerPlus are provided here courtesy of Springer-Verlag