Search tips
Search criteria 


Logo of jclinpathJournal of Clinical PathologyVisit this articleSubmit a manuscriptReceive email alertsContact usBMJ
J Clin Pathol. 1972 July; 25(7): 599–602.
PMCID: PMC477427

Red cell size as measured by the Coulter model S


The MCV (mean corpuscular volume) was examined by the Coulter model S. It was found that the MCV measured by the Coulter S was larger than the generally accepted range 82 to 92, or 76 to 96 μ3. The range in 500 healthy individuals was 82·2 to 100·6 μ3. It was also found that the mean MCV became larger with increasing age. No sex difference was found. The low MCV by manual methods was generally thought to be attributed to less accurate measurement of erythrocyte counts.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (514K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Black PJ. Epitaph for the M.C.H.C. Br Med J. 1971 Nov 20;4(5785):492–493. [PMC free article] [PubMed]
  • Brittin GM, Brecher G, Johnson CA, Elashoff RM. Stability of blood in commonly used anticoagulants. Use of refrigerated blood for quality control of the Coulter Counter Model S. Am J Clin Pathol. 1969 Dec;52(6):690–694. [PubMed]
  • Bull BS. On the distribution of red cell volumes. Blood. 1968 Apr;31(4):503–515. [PubMed]
  • England JM, Walford DM, Waters DA. Epitaph for the M.C.H.C. Br Med J. 1971 Oct 23;4(5781):232–232. [PMC free article] [PubMed]
  • GRAHAM S, LEVIN M, LILIENFELD AM. The socioeconomic distribution of cancer of various sites in Buffalo, N.Y., 1948-1952. Cancer. 1960 Jan-Feb;13:180–191. [PubMed]
  • Hattersley PG, Gerard PW, Caggiano V, Nash DR. Erroneous values on the Model S Coulter Counter due to high titer cold autoagglutinins. Am J Clin Pathol. 1971 Apr;55(4):442–446. [PubMed]
  • HAWKINS WW, SPECK E, LEONARD VG. Variation of the hemoglobin level with age and sex. Blood. 1954 Oct;9(10):999–1007. [PubMed]
  • Lambert RJ, Morris JE. Red cell size and air composition. Br Med J. 1971 Sep 18;3(5776):706–706. [PMC free article] [PubMed]
  • Luke RG, Koepke JA, Siegel RR. The effects of immunosuppressive drugs and uremia on automated leukocyte counts. Am J Clin Pathol. 1971 Oct;56(4):503–507. [PubMed]
  • Myers AM, Saunders CR, Chalmers DG. The haemoglobin level of fit elderly people. Lancet. 1968 Aug 3;2(7562):261–263. [PubMed]
  • Petrucci JV, Dunne PA, Chapman CC. Spurious erythrocyte indices as measured by the model S Coulter counter due to cold agglutinins. Am J Clin Pathol. 1971 Oct;56(4):500–502. [PubMed]
  • Pinkerton PH, Spence I, Ogilvie JC, Ronald WA, Marchant P, Ray PK. An assessment of the Coulter counter model S. J Clin Pathol. 1970 Feb;23(1):68–76. [PMC free article] [PubMed]
  • Sharp AA, Ballard BC. An evaluation of the Coulter S counter. J Clin Pathol. 1970 May;23(4):327–335. [PMC free article] [PubMed]
  • Silver H, Frankel S. Normal values for mean corpuscular volume as determined by the Model S Coulter Counter. Am J Clin Pathol. 1971 Apr;55(4):438–441. [PubMed]

Articles from Journal of Clinical Pathology are provided here courtesy of BMJ Publishing Group