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J Clin Pathol. 1972 April; 25(4): 306–311.
PMCID: PMC477300

Angiofollicular lymph node hyperplasia (Castleman)

Abstract

Six personally observed cases of this lesion are reported and the literature is reviewed. One hundred and thirty-four cases have been reported to date. The lesion has occurred in many sites, but is commonest in the thorax (60%), abdomen (11%), neck (14%), and axilla (4%).

Ninety per cent of cases are symptomless or have only the pressure symptoms, 10% have systemic signs, namely, fever, raised ESR, anaemia, cured by removal of the tumour. These cases have a slightly different histology. All recorded cases have been benign. Microscopically the lesion is follicular but instead of germinal centres the follicles have one or more thick-walled arteries and often some surrounding histiocytes. Increased numbers of vessels occur between the follicles, whilst sinuses are absent. These vessels have thick, cellular walls like post-capillary venules. Sometimes they become hyaline.

The cases with symptoms have true reaction centres as well as a few intrafollicular vessels. Between the follicles there are increased numbers of vessels and, in addition, there may be collections of plasma cells or eosinophils.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • CASTLEMAN B, IVERSON L, MENENDEZ VP. Localized mediastinal lymphnode hyperplasia resembling thymoma. Cancer. 1956 Jul-Aug;9(4):822–830. [PubMed]
  • CASE records of the Massachusetts General Hospital Weekly Clinicopathological Exercises: Case 40011. N Engl J Med. 1954 Jan 7;250(1):26–30. [PubMed]
  • Krasznai G, Juhász I. Angiomatous lymphoid-tissue hyperplasia. J Pathol. 1969 Jan;97(1):148–151. [PubMed]
  • LEE SL, ROSNER F, RIVERO I, FELDMAN F, HURWITZ A. REFRACTORY ANEMIA WITH ABNORMAL IRON METABOLISM: ITS REMISSION AFTER RESECTION OF HYPERPLASTIC MEDIASTINAL LYMPH NODES. N Engl J Med. 1965 Apr 15;272:761–766. [PubMed]
  • Tung KS, McCormack LJ. Angiomatous lymphoid hamartoma. Report of five cases with a review of the literature. Cancer. 1967 Apr;20(4):525–536. [PubMed]
  • Abell MR. Lymphoid hamartoma. Radiol Clin North Am. 1968 Apr;6(1):15–24. [PubMed]
  • BLOMQUIST HE. HYPERPLASTIC MEDIASTINAL LYMPH NODES RESEMBLING THYMOMA. Acta Chir Scand. 1963 Jul-Aug;126:66–77. [PubMed]
  • Cabanne F, Klepping C, Michiels R, Dusserre P. Pseudo-tumeur lympho-vasculaire du médiastin. A propos d'une observation. Arch Anat Pathol (Paris) 1965 Sep;13(3):199–202. [PubMed]
  • Cates GW, Robinson CL. Angiofollicular mediastinal lymph node hyperplasia. Can Med Assoc J. 1967 Dec 16;97(25):1538–1541. [PMC free article] [PubMed]
  • Cierniak J, Zebro T. Lagodne guzowate rozrosty tkanki limfatycznej sródpiersia o typie hamartoma. Patol Pol. 1969 Jul-Sep;20(3):313–323. [PubMed]
  • CLIMIE AR, WAGGONER LG, KRABBENHOFT KL. LYMPHOID HAMARTOMA OF LARYNX. Laryngoscope. 1964 Oct;74:1381–1388. [PubMed]
  • Dybicki J, Boj E, Bartoszewicz T, Bochiński K, Naruszewicz W, Nowakowski J. Dwa przypadki guza Castlemana płuc. Gruzlica. 1966 Jun;34(6):571–575. [PubMed]
  • Fitzpatrick PJ, Brown TC. Angiofollicular lymph node hyperplasia. Can Med Assoc J. 1968 Dec 28;99(25):1259–1262. [PMC free article] [PubMed]
  • GARNEAU R, FOURNIER M. HAMARTOMES ET CHORISTOMES LYMPHO-VASCULAIRES (HYPERPLASIE PSEUDO-TUMORALE DES GANGLIONS M'EDIASTINAUX) Ann Anat Pathol (Paris) 1964 Apr-Jun;9:223–230. [PubMed]
  • Gibbons JR. Benign hilar glandular hyperplasia. Br J Dis Chest. 1966 Oct;60(4):211–212. [PubMed]
  • Griff LC, Griff RE. Mediastinal lymph node hyperplasia--15-year follow-up. Br J Radiol. 1968 Jan;41(481):68–69. [PubMed]
  • Haid SP, Shields TW. Mediastinal lymphoid hamartoma. Arch Surg. 1970 Sep;101(3):442–445. [PubMed]
  • Kernen JA, Morgan ML. Benign lymphoid hamartoma of the vulva. Report of a case. Obstet Gynecol. 1970 Feb;35(2):290–292. [PubMed]
  • Lietz H, Wanger F. Benign lymphoma. Angiofollicular lymph-node hyperplasia. Ger Med Mon. 1969 Jan;14(1):20–22. [PubMed]
  • Lüthi H, Sordat B, Bütler R. Therapieresistente Anämie und humorale Veränderungen bei plasmacellulären hämosiderotischem Tumor im Mesenterium: Ein besonderes Syndrom? Schweiz Med Wochenschr. 1968 Jun 1;98(22):816–821. [PubMed]
  • MacKay JS. Axillary angiofollicular lymph node hyperplasia. Can Med Assoc J. 1969 Mar 1;100(9):434–436. [PMC free article] [PubMed]
  • Maeda M, Hirose H, Nakahara K, Okada T, Iwamoto H. [Pathological studies of "hyperplasia of mediastinal lymph node (Castleman)"]. Kyobu Geka. 1968 Aug;21(8):590–596. [PubMed]
  • Mallory A, Spink WW. Angiomatous lymphoid hamartoma in the retroperitoneum presenting with neurologic signs in the legs. Ann Intern Med. 1968 Aug;69(2):305–308. [PubMed]
  • Mieszczerski J, Meyer J, Welnicki L. Guz miednicy małej typu lymph node hyperplasia. Ginekol Pol. 1965 Nov;36(11):1293–1297. [PubMed]
  • Neerhout RC, Larson W, Mansur P. Mesenteric lymphoid hamartoma associated with chronic hypoferremia, anemia, growth failure and hyperglobulinemia. N Engl J Med. 1969 Apr 24;280(17):922–925. [PubMed]
  • Obrapalska E, Rudnik I, Rudnik J. Przypadek guza Castlemana u 12-letniej dziewczynki. (Olbrzymi przerost wezłw chłonnych śródpiersia) Gruzlica. 1967 Sep;35(9):901–904. [PubMed]
  • Peremans JM, Nijs PH. Giant lymph node hyperplasia. Acta Clin Belg. 1965;20(6):425–430. [PubMed]
  • PIETRA G. HYALINISIERENDE PLASMACELLULAERE LYMPHKNOTENHYPERPLASIE (CASTLEMAN) Schweiz Med Wochenschr. 1964 Dec 12;94:1755–1757. [PubMed]
  • PIETRA G. DIE ANGIO-PLASMAZELLULAERE LYMPHKNOTENHYPERPLASIE CASTLEMAN IM ROENTGENBILD. Fortschr Geb Rontgenstr Nuklearmed. 1964 Dec;101:665–667. [PubMed]
  • Razzuk MA, Shepherd DR, Alvares JF, Urschel HC, Jr, Race GJ, Paulson DL. Angiomatous lymphoid hamartoma of the pulmonary hilum. Ann Thorac Surg. 1970 Apr;9(4):347–351. [PubMed]
  • SAGREIYA K, TALWAR JR. MEDIASTINAL LYMPH NODE HYPERPLASIA. Indian J Pathol Bacteriol. 1964 Apr;55:118–122. [PubMed]
  • Schumann HJ. Zur Kenntnis der angiofollikulären Lymphknotenhyperplasie (Zwiebelschalenlymphom) Zentralbl Allg Pathol. 1966;109(1):67–71. [PubMed]
  • Seiler HH. Lymphoid hamartoma. Ann Thorac Surg. 1970 Apr;9(4):352–355. [PubMed]
  • Talamazzi F, Ravasi G. Iperplasia angiofollicolare dei linfonodi. Tumori. 1965 Jul-Aug;51(4):265–267. [PubMed]
  • TIMME AH. ANGIOFOLLICULAR HYPERPLASIA OF AN ABDOMINAL LYMPH NODE. S Afr Med J. 1965 May 1;39:356–358. [PubMed]
  • WOLFEL DA, ANTONIUS JI, COWLEY RA. POSTERIOR MEDIASTINAL LYMPH NODE HYPERPLASIA. Am J Roentgenol Radium Ther Nucl Med. 1964 Jan;91:120–124. [PubMed]

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