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Logo of jclinpathJournal of Clinical PathologyCurrent TOCInstructions for authors
J Clin Pathol. Oct 1971; 24(7): 617–620.
PMCID: PMC477106
Histochemical detection of the enzyme deficiency in blood films in Wolman's disease
Brian D. Lake
Department of Morbid Anatomy, Institute of Child Health and Hospital for Sick Children, Great Ormond Street, London
The clinical diagnosis of Wolman's disease (acid esterase deficiency) can be confirmed by a histochemical staining method using blood films. Acid esterase activity is found normally in lymphocytes, but in Wolman's disease only a very low level of activity can be detected. An intermediate level of activity was demonstrated in heterozygotes. The method may also be applicable in the prenatal detection of the disease.
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