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J Clin Pathol. 1977 January; 30(1): 19–23.
PMCID: PMC476625

Detection of pregnancy specific beta1-glycoprotein in formalin-fixed tissues.

Abstract

Using an enzyme-bridge immunoperoxidase method, pregnancy specific beta1-glycoprotein (PSbetaG) has been demonstrated in the cytoplasm of the trophoblast in several formalin-fixed tissues, namely, implantation sites of ovum, normal placentae, hydatidiform moles, invasive moles, and choriocarcinomata of uterus and testis. It is suggested that this technique may prove helpful in the detection of choriocarcinomatous elements in malignant tumours.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Bohn H. Isolierung und Charakterisierung des schwanger-schafts-spezifischen beta1-Glykoproteins. Blut. 1972 May;24(5):292–302. [PubMed]
  • Braunstein GD, Vaitukaitis JL, Carbone PP, Ross GT. Ectopic production of human chorionic gonadotrophin by neoplasms. Ann Intern Med. 1973 Jan;78(1):39–45. [PubMed]
  • Horne CH, Towler CM, Pugh-Humphreys RG, Thomson AW, Bohn H. Pregnancy specific beta1-glycoprotein--a product of the syncytiotrophoblast. Experientia. 1976 Sep 15;32(9):1197–1197. [PubMed]
  • Mason TE, Phifer RF, Spicer SS, Swallow RA, Dreskin RB. An immunoglobulin-enzyme bridge method for localizing tissue antigens. J Histochem Cytochem. 1969 Sep;17(9):563–569. [PubMed]
  • Streefkerk JG. Inhibition of erythrocyte pseudoperoxidase activity by treatment with hydrogen peroxide following methanol. J Histochem Cytochem. 1972 Oct;20(10):829–831. [PubMed]
  • Towler CM, Jandial V, Horne CH, Bohn H. A serial study of pregnancy proteins in primigravidae. Br J Obstet Gynaecol. 1976 May;83(5):368–374. [PubMed]
  • Weintraub BD, Rosen SW. Ectopic production of human chorionic somatomammotropin by nontrophoblastic cancers. J Clin Endocrinol Metab. 1971 Jan;32(1):94–101. [PubMed]
  • Pitts A, Williams EE. Letter: Destruction of endogenous peroxidase activity in order to locate cellular antigens by peroxidase-labeled antibodies. J Histochem Cytochem. 1974 Jan;22(1):51–54. [PubMed]

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