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J Clin Pathol. 1977 September; 30(9): 868–877.
PMCID: PMC476578

Acquired cystic disease of the kidneys: a hazard of long-term intermittent maintenance haemodialysis.


In the period 1968-76, necropsies were carried out on 30 patients who had been treated by long-term intermittent maintenance haemodialysis. Fourteen of these patients developed bilateral cystic disease of the kidney. Clinical, pathological, and radiological investigation of these patients when they first presented did not reveal any evidence of renal cystic change. The main complications of this condition are haemorrhage and tumour formation. Six patients developed renal tumours, and in five cases these were multiple. The histological appearance of these neoplasms gave no indication as to whether they would behave in an aggressive manner. One patient died of metastatic carcinomatosis from a renal primary. The condition of acquired cystic disease of the kidney should be suspected if patients on maintenance haemodialysis suffer from recurrent haematuria or are found to have enlarging kidneys.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • The 12th Report of the Human Renal Transplant Registry. Prepared by the Advisory Committee to the Renal Transplant Registry. JAMA. 1975 Aug 18;233(7):787–796. [PubMed]
  • Cabaluna C, Eisinger RP. Gross hematuria as a manifestation of advanced glomerular disease. Nephron. 1974;12(1):59–62. [PubMed]
  • Heptinstall RH. Pathology of end-stage kidney disease. Am J Med. 1968 May;44(5):656–663. [PubMed]
  • Matas AJ, Simmons RL, Kjellstrand CM, Buselmeier TJ, Najarian JS. Increased incidence of malignancy during chronic renal failure. Lancet. 1975 Apr 19;1(7912):883–886. [PubMed]
  • Thaysen JH, Christensen E, Alarcon-Zurita A, Movild B. Involution of polycystic kidneys during active treatment of terminal uremia. Acta Med Scand. 1975 Apr;197(4):257–260. [PubMed]

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