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Biopsy of lymph nodes containing Kaposi's sarcoma from 16 patients showed that the tumour is identical in appearance with that of Kaposi's sarcoma of the skin, regardless of the age of the patient or the mode of presentation. Spread of tumour along sinusoids throughout the lymph node was seen only in the cases of two children with generalised lymphadenopathy, but discrete deposits were present both in lymph nodes regional to skin lesions and in lymph nodes from patients who had presented with primary lymphadenopathy. The reaction of the remainder of incompletely involved nodes was variable. No transition was seen between Kaposi's sarcoma and malignant lymphoma.