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Logo of bmcmethBioMed Centralsearchsubmit a manuscriptregisterthis articleBMC Medical Ethics
 
BMC Med Ethics. 2016; 17: 13.
Published online 2016 February 13. doi:  10.1186/s12910-016-0096-2
PMCID: PMC4752786

Incidental findings of uncertain significance: To know or not to know - that is not the question

Abstract

Background

Although the “right not to know” is well established in international regulations, it has been heavily debated. Ubiquitous results from extended exome and genome analysis have challenged the right not to know. American College of Medical Genetics and Genomics (ACMG) Recommendations urge to inform about incidental findings that pretend to be accurate and actionable. However, ample clinical cases raise the question whether these criteria are met. Many incidental findings are of uncertain significance (IFUS). The eager to feedback information appears to enter the field of IFUS and thereby threaten the right not to know. This makes it imperative to investigate the arguments for and against a right not to know for IFUS.

Discussion

This article investigates how the various arguments for and against a right not to know hold for IFUS. The main investigated arguments are: hypothetical utilitarianism, the right-based argument, the feasibility argument, the value of knowledge argument, the argument from lost significance, the empirical argument, the duty to disclose argument, the avoiding harm argument; the argument from principle, from autonomy, from privacy, as well as the argument from the right to an open future. The analysis shows that both sides in the debate have exaggerated the importance of incidental findings.

Summary

Opponents of a right not to know have exaggerated the importance of IFUS, while proponents have exaggerated the need to be protected from something that is not knowledge. Hence, to know or not to know is not the question. The question is whether we should be able to stay ignorant of incidental findings of uncertain significance, if we want to. The answer is yes: As long as the information is not accurate and/or actionable: ignorance is bliss. When answering questions that are not asked, we need to think twice.

Keywords: Incidental findings, Genetic testing, Genome, Exome, Uncertainty

“Medical science has made such tremendous progress that there is hardly a healthy human left.”

Aldous Huxley

Background

“Do not answer questions not asked.” This general proverb has found many expressions, e.g., in “The Knight’s Tale” from 2001 William exclaims: “Herald, do not answer questions you do not know the answer to!” and in Men in Black Agent K states: “Don’t ask questions you don’t want to know the answer to.” While such statements go well in fiction, in science things are different. Research oftentimes gives us new knowledge that we did not ask for, but that changes the world. In predictive medicine, and in genetics in particular, this is different too. New knowledge is found – knowledge that is important and needs to be communicated. However, when giving answers to questions people do not have, the answers have to be reliable and helpful. That is, they have to be accurate and actionable. If not, people are generally considered to have a right not to be informed. This is highly topical as new omics, such as integrative Personal Omics Profile (iPOP), generates a wealth of data (>3 billion measurements), finding a huge amount of variants (>3 million single nucleotide variants) with uncertain or unknown significance [1]. Even for well characterized genes, such as BRCA1 and BRCA2, there are variants of uncertain significance [2].

The right not to know is recognized in international and national regulation. According to the European Convention on Human Rights and Biomedicine Article 10.2 “[e]veryone is entitled to know any information collected about his or her health. However, the wishes of individuals not to be so informed shall be observed”. In the World Medical Association 1981/1995 Article 7d it is stated that “the patient has the right not to be informed on his/her explicit request, unless required for the protection of another person’s life,” and the UNESCO Declaration on the Human Genome, Article 5c claims that “[t]he right of every individual to decide whether or not to be informed of the results of genetic examination and the resulting consequences should be respected”.

This “right not to know” has been heavily debated [316]. In particular, it has been argued that technological progress in genomics (and other –omics) makes the right not to know obsolete [1723]. The ACMG recommendations for reporting of incidental findings in clinical exome and genome sequencing lists 57 (56) genes and 24 disorders that should be tested when using exome or genome sequencing as these are associated with phenotypes for which “preventive measures and/or treatments [are] available and disorders in which individuals with pathogenic mutations might be asymptomatic for long periods of time.” [24]. Therefore, they favor ignoring patients’ preferences and recognize that in doing so they violate patient autonomy and a right not to know [24]. Moreover, genetics professionals appear to think that to know is better than not to know [25] even when the information is actionable [26].

Although these recommendations have stirred a lively debate [2746] there has been little attention to what kind of information is gained from such tests in practice and how that influences the right not to know. Is the information accurate and actionable, i.e., do they provide helpful knowledge or confusing non-validated information? A recent case referred in The New York Times may illustrate this:

“Jennifer was 39 and perfectly healthy, but her grandmother had died young from breast cancer, so she decided to be tested for mutations in two genes known to increase risk for the disease. When a genetic counselor offered additional tests for 20 other genes linked to various cancers, Jennifer said yes. The more information, the better, she thought. The results, she said, were “surreal.” She did not have mutations in the breast cancer genes, but did have one linked to a high risk of stomach cancer. In people with a family history of the disease, that mutation is considered so risky that patients who are not even sick are often advised to have their stomachs removed. But no one knows what the finding might mean in someone like Jennifer, whose family has not had the disease” [47].

The provided information is not helpful and it is fair to ask whether Jennifer has a right to be ignorant. There are divided opinions about this. However, as the authors in NYT point out, what is revealed in Jennifer’s case is not knowledge, but risk information causing questions, uncertainty, and anxiety [47]. Hence, one could argue that the discussion of a right not to know is irrelevant, as what is presented is not knowledge. It is barely information. It is data with unknown significance.

On the other hand it is argued that this is information about a potential life-threatening risk factor and “that clinicians and laboratory personnel have a fiduciary duty to prevent harm by warning patients and their families about certain incidental findings and that this principle supersedes concerns about autonomy” [24]. Let us for the sake of the argument accept that there is significant uncertainty related to incidental findings in exome and genome analysis. Even ACMG recognizes that “there are insufficient data on penetrance and clinical utility to fully support these recommendations” and “that there was insufficient evidence about benefits, risks, and costs of disclosing incidental findings to make evidence-based recommendations” [24]. Moreover, they acknowledge that to a large extent “the Working Group drew upon the clinical judgment of its members” [24].

As it is argued that we have to discard the right not to know in exome and genome analysis, and this appears to extend to incidental findings of uncertain1 significance2 (IFUS), it becomes imperative to investigate the arguments for and against a right not to know for IFUS. Do the arguments hold? Are they relevant? It will be argued that few of the arguments for and against a right not to know hold for IFUS. Even more, they are not relevant, as IFUS at best is information, and not knowledge3. Hence, there is a right to remain ignorant about test results with uncertain significance. Discussing the right not to know in such cases only confuses the matter. Let me review some of the arguments in order to investigate their relevance, starting with the arguments against the right not to know.

Discussion

Arguments against a “right not to know”

The ACMG recommendations argue from a kind of hypothetical utilitarianism: the information must be conveyed to the person as this will potentially improve the person’s health and potentially even save the life of the person. The argument is in line with traditional arguments for protecting the best interest of a person [48, 49]. “It seems uncontroversial to state that almost everyone would (and perhaps even should) want to know genetic information that could lead to an intervention that would prevent or mitigate serious morbidity or mortality” [18]. One may, of course, argue that it is quite unclear what “would” and “could” means in such statements, and that they are based on biased conception of beneficence, ignoring risk and harm. Let that be as it may. In the case of IFUS it is fundamentally uncertain whether there is any benefit what so ever. Genetic risk scores appear to have lower discriminative accuracy than clinical risk factors, and common complex disorders are only partially heritable. “Most genetic variants may only alter the disease susceptibility risk by a factor of 1.1–1.6, and usually a large number of genetic variants will have a bearing on the risk … In most cases of polymorphic variants, the predictive value would be too small for any intervention to be appropriate ….” [50]. Hence, when accuracy is poor, if existing at all, and actionability is speculative, the argument does not hold. Moreover, there is little evidence of impact on behavior change [49, 51].

There are also right-based arguments against a right not to know. They may be based on third parties rights, e.g. the hypothetical right not to know in the future of one person may be overruled by the right to know (now) of another person, e.g., a parent or guardian: “To mask or withhold the incidental finding is to state that the child’s right not-to-know supersedes the parent’s opportunity to discover a lifethreatening risk factor” [24]. It may also be argued that the right not to know has to be balanced against other rights and other kinds of ethically relevant interests, as it is not a right that outdoes all other considerations [52]. “The idea that there is a general right not to know health information that trumps other interests should be rejected. Such a presumed right must be balanced against other competing rights and other interests.” [53]. E.g., in genetic testing of children it is argued that the benefits of disclosing predictive genetic information to a parent can override the goal of deferring a child’s choice to be tested for that information until adulthood [54].

These arguments presume either that somebody else’s right to know or potential benefit trumps (a potentially acceptable) right not to know. However, in the case of IFUS there is no violation of others’ rights as there is nothing to know (in terms of accuracy and/or actionability), and it is hard to see how rights to know or other interests outrun the right not to know, if there is little to know.

Yet other arguments against a right not to know are arguments from (re)classification. They try to undermine a “right not to know” by arguing that it is not a right [52], only an interest, and that the interest not to know has to be balanced against other interests [7, 55]. However, even if we accept this argument, proponents would have to argue that the interest of being informed about IFUS overrides an interest not to be informed about IFUS.

A related argument against the right not to know claims that it is not a fundamental or a basic right. The right not to know is not found among the basic rights presented in theories of rights. It is derived from other, more fundamental rights, such as freedom or autonomy: “The argument in favour of a right not to know is based on the autonomy of the individual” [8, 56]. Moreover, the right not to know does not always protect the right it is derived from [21, 52, 57]. Again, even if we accept these arguments, it does not follow that there are other more basic rights that trump a right not to be informed about something that is neither accurate nor actionable.

There are also counterarguments from feasibility. E.g., for something to be a right it must be possible to exercise it [58, 59]. Or in another phrasing: to know whether people have a preference not to know, you have to inform them [4]. However, the traditional ought-implies-can-argument does not apply in the IFUS case. Here there is no clear imperative to inform, so the argument falls. On the contrary it illustrates shortcomings of the feasibility argument: if there is little to know, it cannot undermine (or support) a right to know it.

A more principled counter-argument is that knowledge is a good in itself according to which a“right to remain ignorant” is a contradiction. This argument often refers to Aristotle’s conception of man: “all men by nature desire to know” [52] or a Kantian perspective where the “right to remain in ignorance” is an irrational attitude [13, 60, 61]. It may of course also refer to a Socratic/Platonic conception of knowledge to be action-guiding. Hiding information hampers autonomy, and hence, promotes paternalism. In the case of IFUS, it is hard to understand how information can increase autonomy. It is not irrational to refuse information that is not accurate and/or actionable. On the contrary, to claim that you need to know about IFUS, is paternalistic.

There are also counter-arguments from lost significance (or altered relevance). For predictive genetic testing or carrier testing of monogenetic conditions a right not to know makes sense, but in the new setting this right has lost its significance [24, 38]. E.g., ignorance made sense with Huntington’s disease, where little could be done, but it does not make sense in a world of extensive genetic tests of potential great benefit [18, 6264]. This is a petitio principii, as it presumes what has to be proven, i.e., that something can be done. In case of IFUS the information is uncertain and not actionable, and hence, of little relevance.

There are also empirical counter arguments (in addition to the non-feasibility argument mentioned above), e.g., that most people would like to be informed [18] and that only few like not to be informed [53]. In addition to the basic “naturalistic fallacy,” reasoning from is to ought, we do not know what people prefer in the IFUS case. Studies of people’s preferences ask whether they would like to have information that is accurate and actionable, and seldom about uncertain and inactionable information. We do know, however, that genetic professionals tend to think it is good to be informed [25, 26].

Correspondingly, it has been argued that people “are not as autonomous as is generally assumed by the defenders of the right not to know,” [53] and hence, the right not to know has reduced weight. This line of argument refers to studies that show that those few who do not want to know are not fully autonomous [53]. If they were autonomous, they would like to know. This kind of argument raises the obvious question of why we think that only those who do not want to know have reduced autonomy? If people in general have reduced autonomy, the imperative to (be able to) inform them may be as undermined as the right not to know. Be that as it may, in the case of IFUS, the argument fails, as there is nothing to know. There seems to be a fair agreement that autonomy requires understanding, and IFUS does not promote understanding of one’s health.

There is also a counterargument from professional ethics, as the right not to know goes contrary to the doctor’s “duty to disclose” [4]. However, it is not clear that a duty to disclose includes IFUS. On the contrary, and as the case in the introduction illustrates, informing about IFUS may challenge the principle of primum non nocere.

The same goes for another argument from principle, e.g. that a right not to know goes against the principle of solidarity or that it can harm others [65] as it prohibits disclosing vital information to family members. Again, even if one acknowledges and appreciates the solidarity principle or the harm principle, the argument loses force because the information is not vital in the case of IFUS, as it is not accurate or actionable. It is far from obvious that it avoids harm to others. On the contrary, it may cause psychological harm to the person and family members if disclosed.

The legal counterargument does not bite either. One version of the argument goes like this: if a person, who has claimed his right not to know, is given information that was lifesaving, it is hard to see how a jury or judge would blame the persons or institution that gave him the information. Conversely, in a court case with a person who has waived his right not to know would claim that “if I was told that this could be of vital importance to my life and health, I would obviously not have waived the right,” the court may very well agree. Hence, the right not to know would not be valid in judicial practice, and only therefore, at best, be of theoretical interest. However, in the case of IFUS, the lifesaving premise does not hold. If the information is not actionable, it is far from obvious that a court or judge will blame anybody for not informing.

Hence, the arguments against the right not to know do not hold for IFUS. Let me therefore now turn to arguments for a right to know before summarizing the arguments in Table 1.

Table 1
Overview of the arguments for and against a right not to know and short outline of the problems with these arguments

Arguments for a right not to know

One of the main arguments for a right not to know has a (utilitarian) basis in avoiding harm. A person may perfectly well want to stay ignorant in order to avoid psychological harm [4]. In the case of genetic testing of children such harms have been specified: “The potential harms caused by childhood genetic testing might include damage to the child’s self-esteem, distortion of the family’s perceptions of the child, loss of future adult autonomy and confidentiality, discrimination against the child in education, employment or insurance, and adverse effects on the child’s capacity to form future relationships” [66]. If IFUS do not harm a person in these or other ways, this argument may be dismissed. However, if IFUS is able to cause any (psychological) harm, one may argue that the avoiding-harm-argument holds. But not for defending the right not to know, but only for a right not to be informed about IFUS.

Another related argument for the right not to know reasons from future flourishing (and liberty). Knowledge of potential but uncertain risks may reduce human prospering and flourishing. “I should not go hiking, as my genome is not so strong.” I.e., the knowledge may reduce a person’s actual flourishing or liberty. Again, the information of IFUS is not knowledge, and one could argue that it should not be able to reduce anyone’s flourishing or liberty. If it does, one makes erroneous inference from the information. However, if IFUS shows to reduce persons flourishing, one could argue that the argument holds. Again, at best the argument supports a right not to be informed about IFUS.

There are also various autonomy based arguments for a right not to know. E.g. it is argued that choosing not to know is a way to exercise one’s autonomy, i.e., a right to informational self-determination [4]. The patient, and not the professional, should decide what information to be conveyed to the patient. It is the patient who takes on the responsibility and the action of deciding which information he or she wants or does not want to receive [49]. Another argument from (lack of increased) autonomy goes like this: when no alternative treatments or actions are available, knowing does not increase autonomy. Hence, you may as well stay ignorant. Not knowing does not make you subject to paternalism (and i.e., not reduced autonomy). On the contrary, conveying information without the request of the person is a type of paternalism [65]. It can also be argued that present ignorance preserves and promotes the potential of future autonomous choices and that it can be defended from “the right to an open future” – in particular for children [67, 68].

In the case of IFUS, we do not even need to enter the debate on whether you can be autonomous if you do not want to know [49, 54, 68, 69]. It does not seem to threaten a person’s present or future autonomy to refuse information about test results that are not accurate or actionable. However, this does not provide a knock down argument for the right not to know. It only provides an argument for a right not to be informed about IFUS.

There are also arguments for the right not to know from the basic right to privacy. Laurie argues that “[c]ontrol of information about ourselves must be an essential part of any concept of ourselves as autonomous persons, but “control” should not be limited merely to control of who has access to that information. It should also include the facility not to accept the information ab initio. A concept of “control” which is wide enough to encompass this notion permits us to retain a private sphere that is truly our own.” [7]. Although this may justify the non-generation of knowledge in the first place, it is more challenging to use this to argue for a right not to know existing vital information about oneself. However, in the case of IFUS, this is straight forward, as neither the generation, nor the delivery of information, is of known vital importance. However, it may be argued that IFUS does not represent an intrusion into the private sphere, as the meaning of IFUS is unclear. But, as the example with Jennifer in the introduction illustrates, the information may definitely matter. Although, this is not an argument for a right not to know in general, it may be used to argue for not being informed about IFUS.

As with the counter-arguments to the right not to know, there are also empirical arguments for such a right. Many reasonable and autonomous adults choose not to know genetic information of outmost importance to their health. Moreover, some do insist in not knowing such information. E.g., up to 80 % of adults with a family history of Huntington’s disease refuse genetic testing [7072]. As people who can take a very accurate test for a severe disease,4 do not want to know, then others should be given the same option for IFUS. However, this argument reasons from IS to OUGHT. In addition, the empirical premise for the argument is not true in the case of IFUS, as there is little evidence about whether people do or do not want to be informed about IFUS.

There is also an argument for the right not to know from the absence of duties. If there is no duty to inform persons about health risks, e.g., about IFUS on an individual level, then there is a right not to know. However, the absence of a duty does not necessarily correspond to a right, so this argument has to be rephrased: If there is a duty not to inform persons about health risks that are not of vital importance for their lives, then there is a corresponding right not to know health related information that is not of vital importance to one’s life. So far, there are few knock down arguments for a duty not to inform persons about IFUS. It may be reasonable not to inform, but there is no imperative.

Hence, there are a series of arguments for the right not to know, and many problems with them. Table 1 summarizes the arguments for and against the right not to know that have been reviewed so far.

Hence, both the arguments against and for a right not to know do not apply to the case of IFUS. As shown, there are many reasons for this, but one common underlying factor is that IFUS does not represent knowledge. Data - yes, information – maybe, but knowledge – no. Hence, much of the debate on incidental findings of uncertain significance is misplaced. “Looking at the entire genome will reveal “incidental” findings, which are unrelated to the clinical request, as well as a number of genetic variants for which the meaning remains unclear” [49]. Both sides of the debate appear to have hyped the importance of such findings. Those who want to inform have exaggerated the importance of the findings for saving lives, while those who want to stay ignorant have exaggerated the need to be protected from something that is not knowledge (information without significance).

Limitations and reflections

This study is not exhaustive. There may of course be other arguments for and against a right not to know than those presented here. However, would they make a difference? Most arguments for or against refer to some content of the knowledge involved, e.g., either that it is accurate or actionable.

Accordingly, one could dismiss the whole issue of whether there is a right to know or not to know for IFUS in the first place. We could have concluded directly that to know or not to know, that is not the question. The question is: can I trust the information and will it make any change? However, there are three reasons why this investigation has been important. First, the right not to know, and the duty to inform, have been at the core of ethical debates on incidental findings including IFUS. Second, tests that are considered to render significant information, are in practice IFUS. Third, the arguments for or against a right not to know may have been valid for a right not to be informed about IFUS. Actually, several arguments support a right not to be informed about IFUS: if information from genetic tests is not accurate or actionable, I may well be entitled to stay uninformed about these from several perspectives: autonomy, privacy, harm, open future, and flourishing/liberty. However, if well informed about the limited value of IFUS, it is not clear that the information harms or reduces autonomy, future flourishing or liberty. Empirical studies are needed to clarify this and are most welcome.

The interesting thing with using IFUS as a case to discuss the right not to know is that it unpeels a series of arguments that presuppose significant outcomes. E.g., as series of empirical arguments become invalid, as they presuppose that the information “will prevent serious disease and perhaps even save the life” [18] or that most people want information of incidental findings: “…. while the right not to know may seem appropriate in the abstract, people’s views change once they are presented with a case where a specific piece of lifesaving information is available.” [18]. All such arguments presuppose that the information is of importance. However, with IFUS it is not.

In the same way as many of the arguments for informing people of incidental findings presuppose that the information is accurate and actionable, I have here presupposed that it is not, or more precisely, I have defined that IFUS is not accurate or actionable. Hence, I have tried to twist the presuppositions of the con-arguments. It is an empirical question how many test results that are IFUS, and it is an interpretative issue when they are IFUS. But if IFUS exist, I have tried to show that most of the arguments for and against a right to be informed do not apply.

It is of course interesting from a principled point of view to discuss whether there is a right not to know (or a duty to inform). However, when such principled debates, using idealized conditions of accurate and actionable information, are used to regulate practice where such conditions are not met, it is appropriate to revisit the debate and the arguments with real world conditions, e.g., like those of Jennifer at the outset of this article.

It is also an open question what an accurate test result means. For various types of diagnostic tests there are standards of accuracy, e.g., in terms of sensitivity and specificity. Incidental findings for genetic tests can be considered to parallel screening, as there is no indication for the test or the pre-test probability is low. For screening tests there are specific requirements, usually towards 99 % sensitivity and specificity. Accuracy can also be assessed in terms of predictive values (negative and positive predictive values). Genetic test results tend to have low predictive values [50]. Nevertheless, it is a normative question where we set the limits.

It is also an open question what we consider as actionable. I have here considered actions improving a person’s health, because I consider those to be most important in a health care setting. Actions with other purposes may of course be of interest.

In the area of co-production of knowledge one should be careful to give fixed definitions of knowledge. However, the point here has not been to enter the diverse and inconclusive debates on epistemology, but to display that there is a difference between data, information, and knowledge. The point is that dumping data or inaccurate information on people is not making them knowledgeable.

Although I do support a right not to be informed about IFUS, and this article has identified flaws with arguments for and against the right not to know, it is inconclusive with respect to this right in general. Nevertheless, I have revealed a significant asymmetry in how the opponents and proponents appreciate the uncertainties of potential benefits and the uncertainties of potential harms. The point here is that specific uncertainties (in accuracy and actionability) undermine the potentiality of both benefits and harms. Hyping benefits or harms does not help people like Jennifer5.

Conclusion

Most arguments for and against a right not to know fail for IFUS. Mainly because they contain hyped premises of incidental findings’ vital significance or their potential harm respectively. Hence, to know or not to know, that is not the question. The question is: can I trust the test results and will they make any difference? I.e., will I become diseased and can anything be done? IFUS cannot answer these questions. Accordingly, if I cannot trust a test result, and/or (if the result is accurate but) nothing can be done to improve my health, there appear not to be any compelling reason that I should be informed, if I do not want to be. Correspondingly, one could claim a right not to be given inaccurate and/or inactionable information. In the case of IFUS ignorance is bliss. When answering questions that are not asked, we need to think twice.

Acknowledgement

Part of this research has been supported by The Commonwealth Fund through the Harkness Fellowship at The Dartmouth Institute of Health Policy and Clinical Practice (TDI). The views presented here are those of the author and not necessarily those of The Commonwealth Fund their directors, officers, or staff or of TDI.

Footnotes

1In the literature there are many terms for findings of uncertain significance: they are “unspecified,““unknown,” “unclear”. They are also frequently coined “variants of uncertain significance” (VUS), where “uncertain” can be replaced with the terms above. Uncertainty here means that one may know of potential outcomes, but that the probability is unknown. Hence, IFUS is not risk information, as risk contains information of both outcomes and probabilities.

2Significance here is defined as meaning that a test result is accurate (so it can be trusted) and/or that it is actionable, i.e., that something can be done with the effect of improving a person’s (future) health. Technically accuracy is given in terms of sensitivity and specificity, and it does not mean that these have to be 100 %. Moreover, significance does not include that something may be done in the future, e.g., due to new treatments in the future. The “or” between “accurate” and “actionable” acknowledges accurate knowledge may be of value to a person even if it is not actionable.

3Accordingly, knowledge here means that information about a potential health condition following from a test result is accurate or actionable.

4A positive test result is partly (“indirectly”) actionable in terms of family planning (including PGD).

5It may of course be argued that the finding in Jennifer’s case was not an “incidental” finding, but something that was proposed to better assess her (breast) cancer risk. It may have been discussed in a pre-test consultation highlighting the fact the interpretation of positive results in any of 20 the other genes will turn out to be (very) difficult and/or limited. We do not know Jennifer’s reflection when she assented, nor how she interpreted the pre-test information. We only know that she defines the results “surreal,” indicating that the result came as a surprise. I am most thankful to one of the reviewers for pointing this out.

Competing interests

I do not have any financial or other material, professional, or scholarly relationships that involve the area under discussion in this manuscript, i.e., I have no competing interests.

No patients are involved in this study and no ethical approval and consent from patients/ participants is necessary (or possible).

Author’s contribution

I am the sole author of this article and have drafted, written, revised, and submitted the manuscript myself.

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