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J Clin Pathol. 1966 March; 19(2): 103–113.
PMCID: PMC473194

Pathological and clinical findings in a series of 67 cases of medullary carcinoma of the thyroid

Abstract

The pathological features of 67 cases of medullary carcinoma of the thyroid were studied, and when possible the case histories were reviewed.

The typical tumour is sharply demarcated but not encapsulated, is composed of sheets of cells having eosinophilic granular cytoplasm, with the deposition of amyloid in the stroma. We would stress the frequency of binucleate cells, the scarcity of mitoses, and the frequent occurrence of calcification.

The clinical findings show a wide variation in age at presentation of this tumour, and a wide variation in prognosis, with a mean survival from the time of presentation to hospital of 6·6 years, the longest being 21 years. Two of this group of patients also had phaeochromocytomas; these two and three others showed small papillary tumours of the eyelids, lips, and tongue.

Despite the variation in some of its characteristics, medullary carcinoma of the thyroid is considered to be a distinct and sharply defined entity. It appears to be the only type of thyroid carcinoma associated with phaeochromocytoma, the only type associated with multiple mucosal neuromas and the only type with a familial incidence. These findings emphasize the validity of its separation from other types of thyroid carcinoma.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • ALBORES-SAAVEDRA J, ROSE GG, IBANEZ ML, RUSSELL WO, GREY CE, DMOCHOWSKI L. THE AMYLOID IN SOLID CARCINOMA OF THE THYROID GLAND. STAINING CHARACTERISTICS, TISSUE CULTURE, AND ELECTRON MICROSCOPIC OBSERVATIONS. Lab Invest. 1964 Jan;13:77–93. [PubMed]
  • HAZARD JB, HAWK WA, CRILE G., Jr Medullary (solid) carcinoma of the thyroid; a clinicopathologic entity. J Clin Endocrinol Metab. 1959 Jan;19(1):152–161. [PubMed]
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  • VASSAR PS, CULLING CF. The significance of amyloid in carcinoma of the thyroid gland. Am J Clin Pathol. 1961 Sep;36:244–247. [PubMed]
  • WILLIAMS ED. A REVIEW OF 17 CASES OF CARCINOMA OF THE THYROID AND PHAEOCHROMOCYTOMA. J Clin Pathol. 1965 May;18:288–292. [PMC free article] [PubMed]
  • WOOLNER LB, BEAHRS OH, BLACK BM, McCONAHEY WM, KEATING FR., Jr Classification and prognosis of thyroid carcinoma. A study of 885 cases observed in a thirty year period. Am J Surg. 1961 Sep;102:354–387. [PubMed]

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