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Radiographic progression by MBDA score category and serologic status or level of prior joint damage
Frequency of change (Δ) in total Sharp−van der Heijde score (SHS) >3 over the following year was determined for visits (N = 271) subgrouped by MBDA score [low (<30), moderate (30−44) or high (>44)] within groupings by serologic status (A) or amount of prior joint damage (B). Seronegative: negative for both RF and anti-CCP antibody tests; all other patients were considered seropositive. Categories of prior joint damage: SHS ≤18, SHS of 18−53 and SHS >53. Sample sizes and P-values appear in supplementary Tables S4 and S5, respectively, available at Rheumatology Online. MBDA: multi-biomarker disease activity.