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Thorax. 1989 August; 44(8): 668–673.
PMCID: PMC462004

The immunological component of the cellular inflammatory infiltrate in bronchiectasis.


Immunohistological analysis of bronchial biopsy specimens from nine patients with bronchiectasis and four control subjects was performed with a panel of monoclonal antibodies selected to show lymphocyte and macrophage subsets and signs of cellular activation. The cells taking part in the inflammatory response in the bronchial wall of patients with bronchiectasis were almost exclusively mononuclear cells, most of them T lymphocytes. B lymphocytes were observed in biopsy specimens from only two out of nine patients. CD8+ T cells outnumbered CD4+ cells in all patients in a ratio ranging from 2:1 to 10:1. Most T lymphocytes also strongly expressed CD7 antigen and a proportion of them expressed HLA-DR. Most of the lymphocytic infiltration occurred just beneath the basement membrane of the epithelium, though intraepithelial and submucosal infiltration was also seen. Non-lymphoid mononuclear cells expressing the phenotype of dendritic cells and macrophages were found dispersed throughout the infiltrate, most of them expressing HLA-DR. These observations support the hypothesis that cell mediated immunological reactions contribute to the inflammation associated with bronchiectasis.

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Selected References

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  • WHITWELL F. A study of the pathology and pathogenesis of bronchiectasis. Thorax. 1952 Sep;7(3):213–239. [PMC free article] [PubMed]
  • Campbell DA, du Bois RM, Butcher RG, Poulter LW. The density of HLA-DR antigen expression on alveolar macrophages is increased in pulmonary sarcoidosis. Clin Exp Immunol. 1986 Jul;65(1):165–171. [PubMed]
  • Munro CS, Mitchell DN, Poulter LW, Cole PJ. Early cellular responses to intradermal injection of Kveim suspension in normal subjects and those with sarcoidosis. J Clin Pathol. 1986 Feb;39(2):176–182. [PMC free article] [PubMed]
  • Crystal RG, Bitterman PB, Rennard SI, Hance AJ, Keogh BA. Interstitial lung diseases of unknown cause. Disorders characterized by chronic inflammation of the lower respiratory tract. N Engl J Med. 1984 Jan 26;310(4):235–244. [PubMed]
  • Bienenstock J. Mucosal immunological protection mechanisms in the airways. Eur J Respir Dis Suppl. 1986;147:62–71. [PubMed]
  • Bienenstock J, Befus D. Gut- and bronchus-associated lymphoid tissue. Am J Anat. 1984 Jul;170(3):437–445. [PubMed]
  • Unanue ER, Allen PM. The basis for the immunoregulatory role of macrophages and other accessory cells. Science. 1987 May 1;236(4801):551–557. [PubMed]
  • Kallenberg CG, Schilizzi BM, Beaumont F, Poppema S, De Leij L, The TH. Expression of class II MHC antigens on alveolar epithelium in fibrosing alveolitis. Clin Exp Immunol. 1987 Jan;67(1):182–190. [PubMed]
  • Duke O, Panayi GS, Janossy G, Poulter LW. An immunohistological analysis of lymphocyte subpopulations and their microenvironment in the synovial membranes of patients with rheumatoid arthritis using monoclonal antibodies. Clin Exp Immunol. 1982 Jul;49(1):22–30. [PubMed]
  • Poulter LW, Duke O, Panayi GS, Hobbs S, Raftery MJ, Janossy G. Activated T lymphocytes of the synovial membrane in rheumatoid arthritis and other arthropathies. Scand J Immunol. 1985 Dec;22(6):683–690. [PubMed]
  • Janossy G, Prentice HG. T cell subpopulations, monoclonal antibodies and their therapeutic applications. Clin Haematol. 1982 Oct;11(3):631–660. [PubMed]
  • Poulter LW, Collings LA, Tung KS, Waters MF. Parasitism of antigen presenting cells in hyperbacillary leprosy. Clin Exp Immunol. 1984 Mar;55(3):611–617. [PubMed]
  • Munro CS, Campbell DA, Collings LA, Poulter LW. Monoclonal antibodies distinguish macrophages and epithelioid cells in sarcoidosis and leprosy. Clin Exp Immunol. 1987 May;68(2):282–287. [PubMed]
  • Collings LA, Tidman N, Poulter LW. Quantitation of HLA-DR expression by cells involved in the skin lesions of tuberculoid and lepromatous leprosy. Clin Exp Immunol. 1985 Jul;61(1):58–66. [PubMed]

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