PMCCPMCCPMCC

Search tips
Search criteria 

Advanced

 
Logo of thoraxThoraxVisit this articleSubmit a manuscriptReceive email alertsContact usBMJ
 
Thorax. 1984 December; 39(12): 912–918.
PMCID: PMC459952

Bronchial responsiveness to methacholine in chronic bronchitis: relationship to airflow obstruction and cold air responsiveness.

Abstract

The response to inhaled methacholine is increased in patients with chronic airflow obstruction, but it is not known whether this is due to true hyperresponsiveness or is a result of the airflow obstruction. In asthmatics the response to methacholine correlates with the bronchoconstriction produced by hyperventilation of cold dry air. We studied 27 patients with a history of smoking and chronic bronchitis with a range of severity of airflow obstruction. Bronchial responses to methacholine (expressed as the provocation concentration causing a fall in FEV1 of 20%-PC20) and isocapnic hyperventilation of cold dry air were measured. In 19 patients the PC20 was less than 8 mg/ml (that is, in the asthmatic range) but only three developed bronchoconstriction in response to hyperventilation. There was a linear correlation between the log PC20 and the FEV1 (r = 0.86, p less than 0.001). The results suggest that in patients with chronic airflow obstruction the response to methacholine is determined by the degree of airflow obstruction, and cannot be used in the diagnosis of asthma in the absence of additional information.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (990K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Boushey HA, Holtzman MJ, Sheller JR, Nadel JA. Bronchial hyperreactivity. Am Rev Respir Dis. 1980 Feb;121(2):389–413. [PubMed]
  • Bahous J, Cartier A, Ouimet G, Pineau L, Malo JL. Nonallergic bronchial hyperexcitability in chronic bronchitis. Am Rev Respir Dis. 1984 Feb;129(2):216–220. [PubMed]
  • Benson MK. Bronchial hyperreactivity. Br J Dis Chest. 1975 Oct;69(0):227–239. [PubMed]
  • Tattersfield AE. Measurement of bronchial reactivity: a question of interpretation. Thorax. 1981 Aug;36(8):561–565. [PMC free article] [PubMed]
  • O'Byrne PM, Ryan G, Morris M, McCormack D, Jones NL, Morse JL, Hargreave FE. Asthma induced by cold air and its relation to nonspecific bronchial responsiveness to methacholine. Am Rev Respir Dis. 1982 Mar;125(3):281–285. [PubMed]
  • Aquilina AT. Comparison of airway reactivity induced by histamine, methacholine, and isocapnic hyperventilation in normal and asthmatic subjects. Thorax. 1983 Oct;38(10):766–770. [PMC free article] [PubMed]
  • Morris JF, Koski A, Johnson LC. Spirometric standards for healthy nonsmoking adults. Am Rev Respir Dis. 1971 Jan;103(1):57–67. [PubMed]
  • Juniper EF, Frith PA, Dunnett C, Cockcroft DW, Hargreave FE. Reproducibility and comparison of responses to inhaled histamine and methacholine. Thorax. 1978 Dec;33(6):705–710. [PMC free article] [PubMed]
  • Hargreave FE, Ryan G, Thomson NC, O'Byrne PM, Latimer K, Juniper EF, Dolovich J. Bronchial responsiveness to histamine or methacholine in asthma: measurement and clinical significance. J Allergy Clin Immunol. 1981 Nov;68(5):347–355. [PubMed]
  • Youngdahl-Turner P, Rosenberg LE, Allen RH. Binding and uptake of transcobalamin II by human fibroblasts. J Clin Invest. 1978 Jan;61(1):133–141. [PMC free article] [PubMed]
  • Ferrus L, Guenard H, Vardon G, Varene P. Respiratory water loss. Respir Physiol. 1980 Mar;39(3):367–381. [PubMed]
  • Newhouse MT, Ruffin RE. Deposition and fate of aerosolized drugs. Chest. 1978 Jun;73(6 Suppl):936–943. [PubMed]
  • Arnup ME, Mendella LA, Anthonisen NR. Effects of cold air hyperpnea in patients with chronic obstructive lung disease. Am Rev Respir Dis. 1983 Aug;128(2):236–239. [PubMed]
  • Hargreave FE, Ryan G, Thomson NC, O'Byrne PM, Latimer K, Juniper EF, Dolovich J. Bronchial responsiveness to histamine or methacholine in asthma: measurement and clinical significance. J Allergy Clin Immunol. 1981 Nov;68(5):347–355. [PubMed]
  • Barnes PJ, Brown MJ. Venous plasma histamine in exercise- and hyperventilation-induced asthma in man. Clin Sci (Lond) 1981 Aug;61(2):159–162. [PubMed]
  • Lee TH, Nagy L, Nagakura T, Walport MJ, Kay AB. Identification and partial characterization of an exercise-induced neutrophil chemotactic factor in bronchial asthma. J Clin Invest. 1982 Apr;69(4):889–899. [PMC free article] [PubMed]
  • Eliasson O. COPD or not COPD. Am Rev Respir Dis. 1984 Jan;129(1):200–201. [PubMed]
  • Barter CE, Campbell AH. Relationship of constitutional factors and cigarette smoking to decrease in 1-second forced expiratory volume. Am Rev Respir Dis. 1976 Mar;113(3):305–314. [PubMed]

Articles from Thorax are provided here courtesy of BMJ Publishing Group