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Thorax. 1983 October; 38(10): 760–765.
PMCID: PMC459653

Rapid method for measurement of bronchial responsiveness.


A rapid, simple method for measuring bronchial responsiveness to inhaled histamine is described. The method was used to obtain dose response curves in 50 atopic subjects with varying respiratory and nasal symptoms. The cumulative dose of histamine which caused a 20% fall in the one second forced expiratory volume (PD20-FEV1) varied between 0.046 and greater than 3.9 mumol and correlated with the severity of symptoms. The reproducibility of the PD20-FEV1, determined from duplicate measurements in 15 subjects with varying degrees of bronchial responsiveness was found to be satisfactory. When the PD20-FEV1 from this rapid method was compared with that obtained from the dosimeter method no significant difference was found. The dose delivered by this method was shown to be cumulative.

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Selected References

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  • Cockcroft DW, Killian DN, Mellon JJ, Hargreave FE. Bronchial reactivity to inhaled histamine: a method and clinical survey. Clin Allergy. 1977 May;7(3):235–243. [PubMed]
  • Neijens HJ, Hofkamp M, Degenhart HJ, Kerrebijn KF. Bronchial responsiveness as a function of inhaled histamine and the methods of measurement. Bull Eur Physiopathol Respir. 1982 May-Jun;18(3):427–438. [PubMed]
  • Chai H, Farr RS, Froehlich LA, Mathison DA, McLean JA, Rosenthal RR, Sheffer AL, Spector SL, Townley RG. Standardization of bronchial inhalation challenge procedures. J Allergy Clin Immunol. 1975 Oct;56(4):323–327. [PubMed]
  • Beaupré A, Malo JL. Comparison of histamine bronchial challenges with the Wright nebulizer and the dosimeter. Clin Allergy. 1979 Nov;9(6):575–583. [PubMed]
  • Ryan G, Dolovich MB, Roberts RS, Frith PA, Juniper EF, Hargreave FE, Newhouse MT. Standardization of inhalation provocation tests: two techniques of aerosol generation and inhalation compared. Am Rev Respir Dis. 1981 Feb;123(2):195–199. [PubMed]

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