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I read with interest the communication titled “Detection of human papillomavirus in women attending pap cervical screening camp at a peripheral hospital of North Eastern India” by Datta et al published in Med J Armed Forces India 2015; 71(2) 182–185.1 I would like to add the following to the context.
The study highlights HPV and its oncogenic role in cervical cancer disease a well established association now, this being relevant as data from the AFMS which has a substantial population as vaccine candidates is not available. HPV 16/18 vaccines provide over 75% protection against invasive cervical cancer.2 Regarding methodology the use of PGMY L1 consensus primers over MY09/MY11 primer pairs improves detection of HPV in genital samples.3 This suggestion may be useful to increase detection of HPV genotypes in cervical samples. Findings of HPV DNA positivity in almost 60% of inflammatory smears is a clear indicator of the importance of regular follow-up and multiple rounds of screening to identify persistent HPV infections, this maybe expanded to include the immunosuppressed population, definitely a high risk subset.