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Logo of mjafiGuide for AuthorsAbout this journalExplore this journalMedical Journal, Armed Forces India
 
Med J Armed Forces India. 2015 July; 71(3): 307–308.
Published online 2015 July 2. doi:  10.1016/j.mjafi.2015.06.012
PMCID: PMC4534567

Human papillomavirus detection in genital samples by novel PGMY Primers

Mahima Lall, Lt Col

Dear Editor,

I read with interest the communication titled “Detection of human papillomavirus in women attending pap cervical screening camp at a peripheral hospital of North Eastern India” by Datta et al published in Med J Armed Forces India 2015; 71(2) 182–185.1 I would like to add the following to the context.

The study highlights HPV and its oncogenic role in cervical cancer disease a well established association now, this being relevant as data from the AFMS which has a substantial population as vaccine candidates is not available. HPV 16/18 vaccines provide over 75% protection against invasive cervical cancer.2 Regarding methodology the use of PGMY L1 consensus primers over MY09/MY11 primer pairs improves detection of HPV in genital samples.3 This suggestion may be useful to increase detection of HPV genotypes in cervical samples. Findings of HPV DNA positivity in almost 60% of inflammatory smears is a clear indicator of the importance of regular follow-up and multiple rounds of screening to identify persistent HPV infections, this maybe expanded to include the immunosuppressed population, definitely a high risk subset.

References

1. Datta S., Agarwal M., Chatterjee S. Detection of human papillomavirus in women attending Pap cervical screening camp at a peripheral hospital of North-Eastern India. Med J Armed Forces India. 2015;71:182–185. [PubMed]
2. Bhatla N., Lal N., Bao Yan-Ping. A meta-analysis of human papillomavirus type-distribution in women from South Asia: implications for vaccination. Vaccine. 2008;26:2811–2817. [PubMed]
3. Coutlée François, Gravitt Patti, Kornegay Janet. Use of PGMY Primers in L1 consensus PCR improves detection of human papillomavirus DNA in genital samples. J Clin Microbiol. 2002;40:902–907. [PubMed]

Articles from Medical Journal, Armed Forces India are provided here courtesy of Elsevier