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Logo of nihpaAbout Author manuscriptsSubmit a manuscriptHHS Public Access; Author Manuscript; Accepted for publication in peer reviewed journal;
Science. Author manuscript; available in PMC 2016 July 3.
Published in final edited form as:
Science. 2015 July 3; 349(6243): 62–66.
doi: 10.1126/science.aab3753

Fig. 3

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Diversification of pharmaceutical agents

Conditions: a. 5 mol % Cu(OAc)2, 5.5 mol % (S)-DTBM-SEGPHOS, (MeO)2MeSiH, internal olefin, THF, 45 °C. b. (R)-DTBM-SEGPHOS was used instead of (S)-DTBM-SEGPHOS. TFP = 2-(5-trifluoromethyl)pyridyl.

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