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Logo of neurologyNeurologyAmerican Academy of Neurology
 
Neurology. 2015 July 21; 85(3): 295–296.
PMCID: PMC4516295

Reversible cursive agraphia

A 56-year-old right-handed woman, with fine penmanship, presented with inability to perform cursive writing due to calvarial metastasis of a tibial osteosarcoma and left frontal lobe involvement (figures 1 and 2). Tumor resection resulted in a regained capacity for cursive handwriting. Allographs are variants of graphemic representations (upper vs lower case or cursive vs print). Writing requires activation of abstract graphemic representations, selection of the allograph, and formulation of a motor plan.1 Allographic agraphia is rare, affecting the second or third of these processes, differing from other forms of nonaphasic agraphia such as apraxia or visuospatial agraphias.2 It has been associated with left frontal lesions in clinical and imaging studies.2,3

Footnotes

Author contributions: Marcelo Matiello: drafting/revising the manuscript, study concept or design, analysis or interpretation of data, accepts responsibility for conduct of research and final approval. Eli E. Zimmerman: drafting/revising the manuscript, study concept or design, analysis or interpretation of data, accepts responsibility for conduct of research and final approval. David Caplan: analysis or interpretation of data, accepts responsibility for conduct of research and final approval. Adam Cohen: drafting/revising the manuscript, study concept or design, analysis or interpretation of data, accepts responsibility for conduct of research and final approval, acquisition of data, study supervision.

Study funding: No targeted funding reported.

Disclosure: The authors report no disclosures relevant to the manuscript. Go to Neurology.org for full disclosures.

References

1. Rapp B, Caramazza A. From graphemes to abstract letter shapes: levels of representation in written spelling. J Exp Psychol Hum Percept Perform 1997;23:1130–1152. [PubMed]
2. Menichelli A, Machetta F, Zadini A, Semenza C. Allographic agraphia for single letters. Behav Neurol 2012;25:233–244. [PubMed]
3. Planton S, Jucla M, Roux FE, Démonet JF. The “handwriting brain”: a meta-analysis of neuroimaging studies of motor versus orthographic processes. Cortex 2013;49:2772–2287. [PubMed]

Articles from Neurology are provided here courtesy of American Academy of Neurology