Search tips
Search criteria 


Logo of cmajCMAJ Information for AuthorsCMAJ Home Page
CMAJ. 2015 July 14; 187(10): 757.
PMCID: PMC4500700

Quinine and leg cramps

Hans D. Katzberg, MD MSc and Ari Breiner, MD MSc

We would like to respond to Hogan’s commentary,1 which states that quinine is not a safe drug in the treatment of muscle cramps. Hogan points out that nonpharmacologic and other pharmacologic options should be tried before prescribing quinine sulphate.1 But, it is important to note that our previously published recommendations and guidelines2 maintain a clear role for quinine when prescribed by physicians, and when adequate counselling is given to patients and adequate monitoring is in place. Simply calling a drug unsafe may lead to bans similar to those enacted in the United States, which severely limit options for neuromuscular clinicians who care for patients with disabling and terminal conditions such as amyotrophic lateral sclerosis.


1. Hogan DB. Quinine: not a safe drug for treating nocturnal leg cramps. CMAJ 2015;187:237–8. [PMC free article] [PubMed]
2. Katzberg HD, Khan A, So YT. Assessment: symptomatic treatment for muscle cramps (an evidence-based review): report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology. Neurology 2010;74:691–6. [PubMed]

Articles from CMAJ : Canadian Medical Association Journal are provided here courtesy of Canadian Medical Association