Search tips
Search criteria 


Logo of jcinvestThe Journal of Clinical Investigation
J Clin Invest. 1988 June; 81(6): 1666–1668.
PMCID: PMC442608

Passive immunoprophylaxis with specific monoclonal antibody confers partial protection against Pneumocystis carinii pneumonitis in animal models.


Pneumocystis carinii is an important cause of pneumonitis in the immunosuppressed host. Little is known, however, about the biology of this organism. This report demonstrates that a MAb, M5E12, previously shown to be directed against a surface antigen that is present on rat-, rabbit-, ferret-, and human-derived P. carinii, is capable of hindering the development of P. carinii pneumonitis in animal models of this infection when administered throughout the period of immunosuppression. It appears that MAb M5E12 thus has identified a surface antigen of P. carinii that is important in host-parasite interactions.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (664K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Images in this article

Click on the image to see a larger version.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Furuta T, Ueda K, Kyuwa S, Fujiwara K. Effect of T-cell transfer on Pneumocystis carinii infection in nude mice. Jpn J Exp Med. 1984 Apr;54(2):57–64. [PubMed]
  • Furuta T, Ueda K, Fujiwara K. Experimental Pneumocystis carinii infection in nude rats. Jpn J Exp Med. 1984 Apr;54(2):65–72. [PubMed]
  • Furuta T, Ueda K, Fujiwara K, Yamanouchi K. Cellular and humoral immune responses of mice subclinically infected with Pneumocystis carinii. Infect Immun. 1985 Feb;47(2):544–548. [PMC free article] [PubMed]
  • Burke BA, Good RA. Pneumocystis carinii infection. Medicine (Baltimore) 1973 Jan;52(1):23–51. [PubMed]
  • Walzer PD, Rutledge ME. Humoral immunity in experimental Pneumocystis carinii infection. I. Serum and bronchial lavage fluid antibody responses in rats. J Lab Clin Med. 1981 Jun;97(6):820–833. [PubMed]
  • Gigliotti F, Stokes DC, Cheatham AB, Davis DS, Hughes WT. Development of murine monoclonal antibodies to Pneumocystis carinii. J Infect Dis. 1986 Aug;154(2):315–322. [PubMed]
  • Stokes DC, Gigliotti F, Rehg JE, Snellgrove RL, Hughes WT. Experimental Pneumocystis carinii pneumonia in the ferret. Br J Exp Pathol. 1987 Apr;68(2):267–276. [PubMed]
  • Gigliotti F, Insel RA. Protection from infection with Haemophilus influenzae type b by monoclonal antibody to the capsule. J Infect Dis. 1982 Aug;146(2):249–254. [PubMed]
  • Gigliotti F, Shenep JL. Failure of monoclonal antibodies to core glycolipid to bind intact smooth strains of Escherichia coli. J Infect Dis. 1985 Jun;151(6):1005–1011. [PubMed]
  • Lee CH, Bolinger CD, Bartlett MS, Kohler RB, Wilde CE, 3rd, Smith JW. Production of monoclonal antibody against Pneumocystis carinii by using a hybrid of rat spleen and mouse myeloma cells. J Clin Microbiol. 1986 Mar;23(3):505–508. [PMC free article] [PubMed]
  • Graves DC, McNabb SJ, Ivey MH, Worley MA. Development and characterization of monoclonal antibodies to Pneumocystis carinii. Infect Immun. 1986 Jan;51(1):125–133. [PMC free article] [PubMed]
  • Walzer PD, Linke MJ. A comparison of the antigenic characteristics of rat and human Pneumocystis carinii by immunoblotting. J Immunol. 1987 Apr 1;138(7):2257–2265. [PubMed]

Articles from The Journal of Clinical Investigation are provided here courtesy of American Society for Clinical Investigation