Search tips
Search criteria 


Logo of bmjcrBMJ Case ReportsVisit this articleSubmit a manuscriptReceive email alertsContact usBMJ
BMJ Case Rep. 2015; 2015: bcr2014209124.
Published online 2015 March 25. doi:  10.1136/bcr-2014-209124
PMCID: PMC4386302
Case Report

i-gel: a new supraglottic device for effective resuscitation of a very low birthweight infant with Cornelia de Lange syndrome


Laryngeal Mask Airway (LMA) has been indicated as an effective device for airway management when face-mask ventilation and intubation have both failed in infants weighing >2000 g or delivered ≥34 weeks of gestation. All previous studies used a classic LMA. The current report describes the first case of a very low birthweight infant (1470 g, <3rd centile; 36+3gestational weeks) with micrognathia and palate cleft with Cornelia De Lange syndrome, resuscitated at birth with a new supraglottic airway device, i-gel size-1, positioned by a trainee paediatrician at first attempt. The procedure allowed reaching prompt effective ventilation and oxygenation of the patient, who was stabilised and intubated through i-gel.


Laryngeal Mask Airway (LMA) has been indicated as an effective device for airway management if face-mask ventilation and intubation have both failed or are expected to be unfeasible due to airway malformations1 or to the specific work-setting (eg, neonatal transport).2 It has been demonstrated to be easily placed by medic and paramedic staff, or by trainee physicians in adult patients.3 Current guidelines for neonatal resuscitation1 consider LMA as a ‘rescue’ device for neonatal resuscitation in cases of unsuccessful ventilation with face-mask, or unfeasible tracheal intubation for newborns weighing >2000 g or delivered ≥34 weeks of gestation. All previous studies have been conducted with classic LMA (cLMA), and only a few of them enrolled newborns weighing less than 2000 g.4

We report our experience using a new supraglottic device (i-gel) after ineffective face-mask ventilation in a very low birth infant with a prenatal diagnosis of micrognathia.

Case presentation

We present a case of a male infant born at 36+3 weeks of gestation through caesarean section performed because of intrauterine growth retardation (birthweight 1470 g, <3rd centile) and oligoidramnios. He had a prenatal diagnosis of micrognathia; no other congenital malformations were detected; karyotype was normal 46, XY. At birth, the infant was apnoeic, hyporeactive and cyanotic with a heart rate <100 bpm. He was dried, stimulated and, due to the lack of improvement, neonatal resuscitation was started. A trainee paediatrician started face-mask ventilation, but it was ineffective despite adequate corrective manoeuvres. At 2 min of life, an i-gel size 1 was placed by the trainee paediatrician with prompt recovery of heart rate (from 70 to 143 bpm) and transcutaneous saturation. At 5 min of life a 3.0 mm endotracheal tube was electively positioned through the i-gel under endoscopic guidance (figure 1). All phases of the procedure were well tolerated by the patient, maintaining transcutaneous saturation in the range of 83–96%. After the placement of i-gel, we decreased FiO2 from 0.45 to 0.21. The physical examination demonstrated synophrys, micrognathia and cleft palate, low-set ears, syndactyly of second, third and fourth fingers of the left hand. These findings suggested the diagnosis of Cornelia de Lange syndrome.5

Figure 1
Endoscopic-guided intubation through i-gel.


Neonatal upper airway abnormalities represent one of the main causes of difficult/ineffective intubation, especially for personnel with limited expertise in airway management.6 The use of cLMA for neonatal resuscitation in Pierre Robin syndrome7 or in other ‘difficult intubations’, such as Treacher Collins syndrome,8 as a rescue device for maintenance of a patent airway, has been previously reported. Several models of supraglottic airway devices are available, but studies reporting their use in neonatal patients are lacking.6 9

The use of LMA is recommended as a ‘rescue’ approach for neonatal resuscitation if ventilation with face-mask or tracheal intubation is unfeasible or unsuccessful, but it is restricted to newborns weighing >2000 g or aged ≥34weeks of gestation.1

Neonatal i-gel has been observed, in the current case, to be an effective tool to warrant adequate ventilation, even for a trainee paediatrician. The i-gel is an easy to insert, uncuffed supraglottic device. A recent meta-analysis10 showed that i-gel provides a higher leak pressure than cLMA and LMA ProSeal in paediatric patients, suggesting that it provides an efficient seal.

We did not record any complications during insertion. The device provided us with an adequate tool for airway ventilation allowing an ‘elective’ intubation with endoscopic guide after patient stabilisation.

The endoscopic-guided intubation is not routinely available in our delivery room, it has been organised due to the expected birth of a child with an upper airway malformation. However, an upper airway device, such as LMA or i-gel, is always available in our delivery rooms because they may be life-saving tools when ventilation with face-mask or tracheal intubation are unfeasible or unsuccessful.

In case of ‘difficult’ neonatal upper airway, i-gel may represent a life-saving device in case of failure of face-mask ventilation or tracheal intubation.

Learning points

  • The Laryngeal Mask Airway is a life-saving device in patients with congenital upper airway malformations needing neonatal resuscitation.
  • This report describes, for the first time, the use of i-gel for neonatal resuscitation of a very low birthweight infant with Cornelia de Lange syndrome.
  • The resuscitation manoeuvres with i-gel can be effectively conducted by an inexperienced trainee paediatrician.
  • Neonatal i-gel can be used as a conduit for endoscopic intubation.


Competing interests: None.

Patient consent: Obtained.

Provenance and peer review: Not commissioned; externally peer reviewed.


1. Kattwinkel J, Perlman JM, Aziz K, et al. ., American Heart Association Neonatal resuscitation: 2010 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. Pediatrics 2010;126:e1400–13 doi:10.1542/peds.2010-2972E [PubMed]
2. Trevisanuto D. Laryngeal mask airway for the interhospital transport of neonates. Pediatrics 2005;115:e109–11. [PubMed]
3. Trevisanuto D, Parotto M, Doglioni N et al. The supreme Laryngeal Mask Airway (LMA): a new neonatal supraglottic device: comparison with Classic and ProSeal LMA in a manikin. Resuscitation 2012;83:97–100 doi:10.1016/j.resuscitation.2011.07.032 [PubMed]
4. Trevisanuto D, Micaglio M, Pitton M et al. Laryngeal mask airway: is the management of neonates requiring positive pressure ventilation at birth changing? Resuscitation 2004;62:151–7 doi:10.1016/j.resuscitation.2004.03.006 [PubMed]
5. Boyle MI, Jespersgaard C, Brøndum-Nielsen K et al. Cornelia de Lange syndrome. Clin Genet 2014. Sep 11. doi: 10.1111/cge.12499. [Epub ahead of print] doi:10.1111/cge.12499 [PubMed]
6. Schmölzer GM, Agarwal M, Kamlin CO et al. Supraglottic airway devices during neonatal resuscitation: an historical perspective, systematic review and meta-analysis of available clinical trials. Resuscitation 2013;84:722–30 doi:10.1016/j.resuscitation.2012.11.002 [PubMed]
7. Gandini D, Brimacombe J Laryngeal mask airway for ventilatory support over a 4-day period in a neonate with Pierre Robin sequence. Paediatr Anaesth 2003;13:181–2 doi:10.1046/j.1460-9592.2003.01019_4.x [PubMed]
8. Bucx MJL, Grolman W, Kruisinga FH et al. The prolonged use of the laryngeal mask airway in a neonate with airway obstruction and Treacher Collins syndrome. Paediatr Anaesth 2003;13:530–3 doi:10.1046/j.1460-9592.2003.01108.x [PubMed]
9. de Lloyd LJ, Subash F, Wilkes AR et al. A comparison of fibreoptic-guided tracheal intubation through the Ambu® Aura-i, the intubating laryngeal mask airway and the i-gel: a manikin study. Anaesthesia 2010;65:36–43 doi:10.1111/anae.12988 [PubMed]
10. Maitra S, Baidya DK, Bhattacharjee S et al. Evaluation of i-gel airway in children: a meta-analysis. Paediatr Anaesth 2014;24:1072–9 doi:10.1111/pan.12483 [PubMed]

Articles from BMJ Case Reports are provided here courtesy of BMJ Publishing Group