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J Clin Invest. 1983 May; 71(5): 1124–1129.
PMCID: PMC436973

Prenatal allergic sensitization to helminth antigens in offspring of parasite-infected mothers.

Abstract

Total and filaria-specific immunoglobulin E (IgE) levels were studied in cord blood from infants born in Madras, India, where filariasis and intestinal helminth infections are highly endemic. Increased total IgE levels were observed in 82% of 57 cord sera tested (geometric mean 12.6 ng/ml; range 1-1,900 ng/ml). 33 of these sera also contained IgE antibodies specific for filarial antigens as determined by solid-phase radioimmunoassay. Comparison of ratios of filaria-specific IgE to total IgE in paired maternal and cord sera suggested that cord blood IgE was derived from the fetus in most cases and not from transplacental antibody transfer. Our results suggest that prenatal allergic sensitization to helminth parasites occurs in the tropics. Such sensitization may contribute to the heterogeneity in host immune response and disease expression noted in filariasis and other helminth infections.

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Selected References

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  • Miller DL, Hiravonen T, Gitlin D. Synthesis of IgE by the human conceptus. J Allergy Clin Immunol. 1973 Sep;52(3):182–188. [PubMed]
  • Kaufman HS. Allergy in the newborn: skin test reactions confirmed by the Prausnitz-Küstner test at birth. Clin Allergy. 1971 Dec;1(4):363–367. [PubMed]
  • Michel FB, Bousquet J, Greillier P, Robinet-Levy M, Coulomb Y. Comparison of cord blood immunoglobulin E concentrations and maternal allergy for the prediction of atopic diseases in infancy. J Allergy Clin Immunol. 1980 Jun;65(6):422–430. [PubMed]
  • Kjellman NM, Johansson SG, Roth A. Serum IgE levels in healthy children quantified by a sandwich technique (PRIST). Clin Allergy. 1976 Jan;6(1):51–59. [PubMed]
  • Kjellman NI, Johansson SG. IgE and atopic allergy in newborns and infants with a family history of atopic disease. Acta Paediatr Scand. 1976 Sep;65(5):601–607. [PubMed]
  • Ganju A, Baram P, Lim DT. Serum IgE levels in healthy black American children: a case for environmental influences on IgE. Ann Allergy. 1979 Nov;43(5):271–274. [PubMed]
  • Thomas J, Abrishami MA, Chehreh MN, Walters CS. Neonatal IgE values in the black population. Ann Allergy. 1979 Sep;43(3):144–145. [PubMed]
  • Katz DH. Recent studies on the regulation of IgE antibody synthesis in experimental animals and man. Immunology. 1980 Sep;41(1):1–24. [PubMed]
  • Santoro F, Prata A, Castro CN, Capron A. Circulating antigens, immune complexes and C3d levels in human schistosomiasis: relationship with Schistosoma mansoni egg output. Clin Exp Immunol. 1980 Nov;42(2):219–225. [PubMed]
  • Dennis DT, McConnell E, White GB. Bancroftian filariasis and membrane filters: are night surveys necessary? Am J Trop Med Hyg. 1976 Mar;25(2):257–262. [PubMed]
  • Ottesen EA, Neva FA, Paranjape RS, Tripathy SP, Thiruvengadam KV, Beaven MA. Specific allergic sensitsation to filarial antigens in tropical eosinophilia syndrome. Lancet. 1979 Jun 2;1(8127):1158–1161. [PubMed]
  • Hussain R, Hamilton RG, Kumaraswami V, Adkinson NF, Jr, Ottesen EA. IgE responses in human filariasis. I. Quantitation of filaria-specific IgE. J Immunol. 1981 Oct;127(4):1623–1629. [PubMed]
  • Hamilton RG, Hussain R, Ottesen EA, Adkinson NF., Jr The quantitation of parasite-specific human IgG and IgE in sera: evaluation of solid-phase RIA and ELISA methodology. J Immunol Methods. 1981;44(1):101–114. [PubMed]
  • Ottesen EA, Kumaraswami V, Paranjape R, Poindexter RW, Tripathy SP. Naturally occurring blocking antibodies modulate immediate hypersensitivity responses in human filariasis. J Immunol. 1981 Nov;127(5):2014–2020. [PubMed]
  • Beaven MA, Jacobsen S, Horáková Z. Modification of the enzymatic isotopic assay of histamine and its application to measurement of histamine in tissues, serum and urine. Clin Chim Acta. 1972 Mar;37:91–103. [PubMed]
  • ZAROU DM, LICHTMAN HC, HELLMAN LM. THE TRANSMISSION OF CHROMIUM-51 TAGGED MATERNAL ERYTHROCYTES FROM MOTHER TO FETUS. Am J Obstet Gynecol. 1964 Mar 1;88:565–571. [PubMed]
  • Mendoza GR, Minagawa K, Orner FB, Stiehm ER. Basophil releasability in the newborn: factors limiting immunoglobulin E-mediated histamine release. Pediatrics. 1982 Feb;69(2):188–192. [PubMed]
  • Weiss N, Hussain R, Ottesen EA. IgE antibodies are more species-specific than IgG antibodies in human onchocerciasis and lymphatic filariasis. Immunology. 1982 Jan;45(1):129–137. [PubMed]
  • Miller GC. Helminths and the transmammary route of infection. Parasitology. 1981 Apr;82(Pt 2):335–342. [PubMed]
  • Lewert RM, Mandlowitz S. Schistosomiasis: prenatal induction of tolerance to antigens. Nature. 1969 Dec 6;224(5223):1029–1030. [PubMed]
  • Dissanayake S, de Silva LV, Ismail MM. IgM antibody to filarial antigens in human cord blood: possibility of transplacental infection. Trans R Soc Trop Med Hyg. 1980;74(4):542–544. [PubMed]

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