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J Clin Invest. 1983 April; 71(4): 859–866.
PMCID: PMC436943

Feedback inhibition of adrenocorticotropic hormone by physiological increases in plasma corticosteroids in conscious dogs.


We have tested the effect of physiological increases in plasma corticosteroids in conscious dogs on the levels of basal and hypoglycemia-stimulated adrenocorticotropic hormone (ACTH) 2 h later. Increases in plasma corticosteroids, produced by infusion of alpha-1-24 ACTH or corticosteroids for 40 min, suppressed basal and stimulated ACTH levels. The magnitude of inhibition produced by an increase in plasma corticosteroids induced by the infusion of ACTH was equivalent to the inhibition produced by the same increase in plasma corticosteroids induced by corticosteroid infusion. The infusions did not affect basal plasma glucose concentrations or the decrease in plasma glucose concentrations after administration of 0.1 U insulin/kg. Basal ACTH concentration was less sensitive than hypoglycemia-stimulated ACTH concentration to corticosteroid-induced suppression. Basal and stimulated secretion were significantly inhibited in all dogs after approximately half-maximal increases in plasma corticosteroids; maximum inhibition occurred after maximal increases in plasma corticosteroids. Therefore, physiological increments in plasma corticosteroids, similar to those produced by acute stress, are effective suppressors of subsequent stress-induced ACTH secretion.

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Selected References

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  • Aron DC, Tyrrell JB, Fitzgerald PA, Findling JW, Forsham PH. Cushing's syndrome: problems in diagnosis. Medicine (Baltimore) 1981 Jan;60(1):25–35. [PubMed]
  • Fehm HL, Voigt KH, Kummer G, Lang R, Pfeiffer EF. Differential and integral corticosteroid feedback effects on ACTH secretion in hypoadrenocorticism. J Clin Invest. 1979 Feb;63(2):247–253. [PMC free article] [PubMed]
  • Reader SC, Alaghband-Zadeh J, Daly JR, Robertson WR. Negative rate-sensitive feedback effects on adrenocorticotrophin secretion by cortisol in normal subjects. J Endocrinol. 1982 Mar;92(3):443–448. [PubMed]
  • Keller-Wood ME, Shinsako J, Keil LC, Dallman MF. Insulin-induced hypoglycemia in conscious dogs. I. Dose-related pituitary and adrenal responses. Endocrinology. 1981 Sep;109(3):818–824. [PubMed]
  • Dallman MF, Yates FE. Dynamic asymmetries in the corticosteroid feedback path and distribution-metabolism-binding elements of the adrenocortical system. Ann N Y Acad Sci. 1969 Apr 21;156(2):696–721. [PubMed]
  • HECHTER O, MACCHI IA, KORMAN H, FRANK ED, FRANK HA. Quantitative variations in the adrenocortical secretion of dogs. Am J Physiol. 1955 Jul;182(1):29–34. [PubMed]
  • Dallman MF, DeManincor D, Shinsako J. Diminishing corticotrope capacity to release ACTH during sustained stimulation: the twenty-four hours after bilateral adrenalectomy in the rat. Endocrinology. 1974 Jul;95(1):65–73. [PubMed]
  • Murphy BE. Some studies of the protein-binding of steroids and their application to the routine micro and ultramicro measurement of various steroids in body fluids by competitive protein-binding radioassay. J Clin Endocrinol Metab. 1967 Jul;27(7):973–990. [PubMed]
  • Wood CE, Shinsako J, Keil LC, Ramsay DJ, Dallman MF. Apparent dissociation of adrenocorticotropin and corticosteroid responses to 15 ml/kg hemorrhage in conscious dogs. Endocrinology. 1982 Apr;110(4):1416–1421. [PubMed]
  • Raff H, Tzankoff SP, Fitzgerald RS. ACTH and cortisol responses to hypoxia in dogs. J Appl Physiol Respir Environ Exerc Physiol. 1981 Nov;51(5):1257–1260. [PubMed]
  • Beirne J, Jubiz W. Effect of indomethacin on the hypothalamic-pituitary-adrenal axis in man. J Clin Endocrinol Metab. 1978 Oct;47(4):713–716. [PubMed]
  • Dallman MF, Jones MT, Vernikos-Danellis J, Ganong WF. Corticosteroid feedback control of ACTH secretion: rapid effects of bilateral adrenalectomy on plasma ACTH in the rat. Endocrinology. 1972 Oct;91(4):961–968. [PubMed]
  • Zimmermann E, Critchlow V. Short-latency suppression of pituitary-adrenal function with physiological plasma levels of corticosterone in the female rat. Neuroendocrinology. 1972;9(4):235–243. [PubMed]
  • SMELIK PG. Relation between blood level of corticoids and their inhibiting effect on the hypophyseal stress response. Proc Soc Exp Biol Med. 1963 Jul;113:616–619. [PubMed]

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