KGF treatment of M. tuberculosis-infected mice prevents weight loss and reduces M. tuberculosis proliferation in the lung. C57BL/6 mice were treated with KGF (5 mg/kg) or saline i.n. and then inoculated i.n. with 1 × 105M. tuberculosis bacilli (Erdman) 24 h. later. Animals were divided into four groups: serial KGF or saline treatment every 3 days for 45 days or 15 days of KGF or saline treatment followed by crossover to the other group for days 30–45. Body weights (A) and M. tuberculosis cfu in homogenized lungs (B) were assessed for 45 days at the indicated time points. The data are expressed as mean ± S.E. (error bars) (n = 4 mice/group).