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Logo of bmcurolBioMed Centralsearchsubmit a manuscriptregisterthis articleBMC Urology
 
BMC Urol. 2004; 4: 5.
Published online Jun 5, 2004. doi:  10.1186/1471-2490-4-5
PMCID: PMC425587
Adult Wilms' tumor with calcification untreated for 5 years – a case report
Hiroshi Masuda,1,2 Haruhito Azuma,corresponding author2 Fumitaka Nakajima,2 Toshikazu Watsuji,1 and Yoji Katsuoka2
1Department of Urology, Hirakata City Hospital, Hirakata, Osaka 569-8686, Japan
2Department of Urology, Osaka Medical College, Takatsuki, Osaka 569-8686, Japan
corresponding authorCorresponding author.
Hiroshi Masuda: m3255makiko/at/r2.dion.ne.jp; Haruhito Azuma: uro004/at/poh.osaka-med.ac.jp; Fumitaka Nakajima: uro007/at/poh.osaka-med.ac.jp; Toshikazu Watsuji: hhp08-watsuji/at/kcat.zaq.ne.jp; Yoji Katsuoka: uro001/at/poh.osaka-med.ac.jp
Received February 6, 2004; Accepted June 5, 2004.
Background
Wilms' tumor is rarely found in adults and there are no established treatment guidelines for such tumors in adults. Whereas calcification is a common finding in neuroblastoma, it is considered uncommon in Wilms' tumor.
Case presentation
We report a case of adult Wilms' tumor with calcification in a 22-year-old man. He had been initially referred to our hospital with a chief complaint of right flank pain 5 years previously, when abdominal computed tomography had revealed focal calcification at the upper pole of the right kidney. Although we planned further assessment, he did not revisit our hospital again until 5 years later, again because of right flank pain. Ultrasound and computed tomography scan revealed a large mass lesion with calcification in the right kidney, invasive to the hepatic lobe. The patient underwent curative right nephrectomy and partial right hepatic lobectomy. Pathological analysis demonstrated a nephroblastoma (Wilms' tumor) with predominant epithelial histology infiltrating the hepatic lobe. The patient has been well without tumor recurrence for 15 months after surgery.
Conclusions
Calcification may be a sign of slow tumor gowth and possibly a favorable prognosis in cases of adult Wilms' tumor.
Keywords: prognosis, nephroblastoma
Background
Wilms' tumor mostly occurs in childhood, and there are no established treatment guidelines for such tumors in adults. Whereas calcification is a common finding in cases of neuroblastoma, it is considered uncommon in Wilms' tumor. Here we describe a case of adult Wilms' tumor with calcification in a 22-year-old man, who was untreated for 5 years but made a good recovery without disease progression after surgery. Calcification may be a sign of slow tumor growth and possibly a favorable prognosis in cases of Wilms' tumor in adults.
A 17-year-old man with a chief complaint of right flank pain was referred to our hospital. Abdominal computed tomography (CT) revealed focal calcification at the upper pole of the right kidney (Fig. 1-a). We suspected renal stones in a caliceal diverticulum, and planned further assessment including drip infusion pyelography (DIP). However, because the patient became asymptomatic, he made no further visits to our hospital for 5 years. At the age of 22 years, however, he presented again because of right flank pain. DIP demonstrated focal calcification at the upper pole of the right kidney, and ultrasound (US) and CT scan demonstrated a large right renal mass with calcification invading the hepatic lobe (Figs. 1-b, and 1-c). Selective renal arterial angiography demonstrated a hypovascular tumor in the same area where the mass lesion had been observed by US, DIP, and CT. The patient underwent curative right nephrectomy and partial right hepatic lobectomy under a diagnosis of malignant renal tumor. The upper pole of the extirpated kidney was occupied by the tumor, which adhered tightly to the liver. The mass was completely removed along with the hepatic lobe, without rupture. No other invasion or lymph node metastasis was found. Macroscopic examination showed an encapsulated tumor with calcification that had infiltrated hepatic lobe (Fig. (Fig.2).2). The specimen weighed 280.0 g. The cut surface was solid and homogeneously white-yellow. Pathological analysis demonstrated a nephroblastoma (Wilms' tumor) with a predominantly epithelial histology that had infiltrated the hepatic lobe. The disease was classified as stage II according to the National Wilms' Tumor Study classification. After surgery, the patient received adjuvant chemotherapy with vincristine-actinomycin D for 60 weeks. He has been well without tumor recurrence for 15 months after surgery.
Figure 1
Figure 1
Abdominal computed tomography scans taken at the first (a) and second (b) visits, and drip infusion pyelography conducted at the second visit (c) a) Focal calcification at the upper pole of the right kidney. b) A large right renal mass with calcification, (more ...)
Figure 2
Figure 2
Macroscopic appearance of the tumor The tumor is encapsulated with calcification (arrows), and shows invasion to the hepatic lobe.
Wilms' tumor is rare in adults, whereas it is the most common renal tumor in children. Adult Wilms' tumor may have a more aggressive clinical course and a higher tumor stage at the time of diagnosis compared with that in children [1]. In the present case, the patient presented with a chief complaint of right flank pain, and abdominal CT revealed focal calcification at the upper pole of the right kidney. We suspected renal stones in a caliceal diverticulum, and planned further assessment including DIP, but the patient did not visit our hospital again for a further 5 years, by which time his clinical stage had progressed to stage II from stage I at the time of initial diagnosis, according to the National Wilms' Tumor Study classification. Intratumoral calcification is a common finding in neuroblastoma, but rare in Wilms' tumor [2]. The incidence of radiographically demonstrable calcification in primary Wilms' tumor varies between 3% and 17% [3]. It has not been clarified whether there is a significant relationship between tumor calcification and histology, grade, or patient prognosis. However, several previous reports have demonstrated that although calcified tumors may be relatively large, they tend to be localized and histologically well differentiated. This may indicate that calcified tumors are slow-growing and that calcification in Wilms' tumor may be a sign of a favorable prognosis [4]. In the present case, the 5-year delay in treatment was unfortunate because this allowed the tumor to become large and invade the liver. However, the patient has been well without tumor recurrence for 15 months after radical surgery. This may also support the concept that calcified Wilms' tumors in adults show a low degree of aggressiveness.
Conclusions
Calcification in adult Wilms' tumor may be a sign of slow tumor growth and possibly a favorable prognosis.
Pre-publication history
The pre-publication history for this paper can be accessed here:
References
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  • Krieger JN, Sinderman KW, Seligson GR. Calcified renal cell carcinoma: a clinical, radiographic and pathologic study. J Urol. 1979;121:575–580. [PubMed]
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