Search tips
Search criteria 


Logo of jcinvestThe Journal of Clinical Investigation
J Clin Invest. 1987 April; 79(4): 1234–1241.
PMCID: PMC424320

Role of local immunosuppression in murine fetoplacental listeriosis.


Recent evidence suggests that local immunoregulation may prevent rejection of the placenta by the mother. This local immunoregulation may also compromise the response to placental infection. Listeria monocytogenes infection in 121 pregnant mice and 1,050 fetoplacental units was examined and the kinetics of bacterial growth in various maternal and fetal tissues were determined. A subset of pregnant mice developed overwhelming placental listeria infections. Pregnancy did not impair the maternal immune response in the liver and spleen. Pregnant mice without placental infection had numbers of listeria equivalent to nonpregnant controls and mice immunized during pregnancy had significantly less listeria than nonimmunized controls. The secondary response in immunized pregnant mice had no effect on the development of placental infection and the histologic features of placental infection were distinct from those in other organs. Our data suggest that an ineffective local immune response may contribute to the pathogenicity of listeria for the placenta.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (2.1M), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Images in this article

Click on the image to see a larger version.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Giraud JR, Denis F, Gargot F, Fizazi T, Babin P, Rautlin de la Roy Y DE, Hoppeler A, Brisou J, de Tourris H. La listériose. Incidence dans les interruptions spontanées de la grossesse. Nouv Presse Med. 1973 Jan 27;2(4):215–218. [PubMed]
  • Vawter GF. Perinatal listeriosis. Perspect Pediatr Pathol. 1981;6:153–166. [PubMed]
  • Hunziker RD, Wegmann TG. Placental immunoregulation. Crit Rev Immunol. 1986;6(3):245–285. [PubMed]
  • Clark DA, Chaput A, Walker C, Rosenthal KL. Active suppression of host-vs-graft reaction in pregnant mice. VI. Soluble suppressor activity obtained from decidua of allopregnant mice blocks the response to IL 2. J Immunol. 1985 Mar;134(3):1659–1664. [PubMed]
  • Badet MT, Bell SC, Billington WD. Immunoregulatory activity of supernatants from short-term cultures of mouse decidual tissue. J Reprod Fertil. 1983 Jul;68(2):351–358. [PubMed]
  • Chaouat G, Kolb JP. Immunoactive products of placenta. IV. Impairment by placental cells and their products of CTL function at effector stage. J Immunol. 1985 Jul;135(1):215–222. [PubMed]
  • Rocklin RE, Kitzmiller JL, Carpenter CB, Garovoy MR, David JR. Maternal-fetal relation. Absence of an immunologic blocking factor from the serum of women with chronic abortions. N Engl J Med. 1976 Nov 25;295(22):1209–1213. [PubMed]
  • Beer AE, Sio JO. Placenta as an immunological barrier. Biol Reprod. 1982 Feb;26(1):15–27. [PubMed]
  • Muchmore AV, Decker JM. Uromodulin: a unique 85-kilodalton immunosuppressive glycoprotein isolated from urine of pregnant women. Science. 1985 Aug 2;229(4712):479–481. [PubMed]
  • Luft BJ, Remington JS. Effect of pregnancy on resistance to Listeria monocytogenes and Toxoplasma gondii infections in mice. Infect Immun. 1982 Dec;38(3):1164–1171. [PMC free article] [PubMed]
  • Hamada M, Kuroiwa A, Matsumoto T, Nomoto K, Takeya K. Modification of protective mechanisms against Listeria monocytogenes during pregnancy. J Clin Lab Immunol. 1981 Sep;6(2):169–173. [PubMed]
  • Bortolussi R, Campbell N, Krause V. Dynamics of Listeria monocytogenes type 4b infection in pregnant and infant rats. Clin Invest Med. 1984;7(4):273–279. [PubMed]
  • Hahn H, Kaufmann SH. The role of cell-mediated immunity in bacterial infections. Rev Infect Dis. 1981 Nov-Dec;3(6):1221–1250. [PubMed]
  • Lane FC, Unanue ER. Requirement of thymus (T) lymphocytes for resistance to listeriosis. J Exp Med. 1972 May 1;135(5):1104–1112. [PMC free article] [PubMed]
  • Cheers C, McKenzie IF. Resistance and susceptibility of mice to bacterial infection: genetics of listeriosis. Infect Immun. 1978 Mar;19(3):755–762. [PMC free article] [PubMed]
  • Skamene E, Kongshavn PA, Sachs DH. Resistance to Listeria monocytogenes in mice: genetic control by genes that are not linked to the H-2 complex. J Infect Dis. 1979 Feb;139(2):228–231. [PubMed]
  • Mandel TE, Cheers C. Resistance and susceptibility of mice to bacterial infection: histopathology of listeriosis in resistant and susceptible strains. Infect Immun. 1980 Dec;30(3):851–861. [PMC free article] [PubMed]
  • Croy BA, Rossant J, Clark DA. Histological and immunological studies of post implantation death of Mus caroli embryos in the Mus musculus uterus. J Reprod Immunol. 1982 Sep;4(5):277–293. [PubMed]
  • Clark DA, Chaput A, Tutton D. Active suppression of host-vs-graft reaction in pregnant mice. VII. Spontaneous abortion of allogeneic CBA/J x DBA/2 fetuses in the uterus of CBA/J mice correlates with deficient non-T suppressor cell activity. J Immunol. 1986 Mar 1;136(5):1668–1675. [PubMed]
  • DRISCOLL SG, GORBACH A, FELDMAN D. Congenital listeriosis: diagnosis from placental studies. Oncologia. 1962 Aug;20:216–220. [PubMed]
  • Chatterjee-Hasrouni S, Lala PK. MHC antigens on mouse trophoblast cells: paucity of Ia antigens despite the presence of H-2K and D. J Immunol. 1981 Nov;127(5):2070–2073. [PubMed]
  • Anderson DJ, Berkowitz RS. Gamma-interferon enhances expression of Class I MHC antigens in the weakly HLA+ human choriocarcinoma cell line BeWo, but does not induce MHC expression in the HLA- choriocarcinoma cell line Jar. J Immunol. 1985 Oct;135(4):2498–2501. [PubMed]
  • Lu CY, Changelian PS, Unanue ER. Alpha-fetoprotein inhibits macrophage expression of Ia antigens. J Immunol. 1984 Apr;132(4):1722–1727. [PubMed]
  • Snyder DS, Beller DI, Unanue ER. Prostaglandins modulate macrophage Ia expression. Nature. 1982 Sep 9;299(5879):163–165. [PubMed]

Articles from The Journal of Clinical Investigation are provided here courtesy of American Society for Clinical Investigation