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Logo of arthrestherBioMed Centralbiomed central web sitesearchsubmit a manuscriptregisterthis articleArthritis Research & Therapy
 
Arthritis Res Ther. 2004; 6(3): 93–97.
Published online Apr 1, 2004. doi:  10.1186/ar1172
PMCID: PMC416447
Chemokine blockade: a new era in the treatment of rheumatoid arthritis?
Jasper J Haringman1 and Paul P Takcorresponding author1
1Division of Clinical Immunology and Rheumatology, Academic Medical Centre/University of Amsterdam, Amsterdam, The Netherlands
corresponding authorCorresponding author.
Jasper J Haringman: j.j.haringman/at/amc.uva.nl; Paul P Tak: p.p.tak/at/amc.uva.nl
Abstract
Blockade of chemokines or chemokine receptors is emerging as a new potential treatment for various immune-mediated conditions. This review focuses on the therapeutic potential in rheumatoid arthritis, based on studies in animal models and patients. Several knockout models as well as in vivo use of chemokine antagonists are discussed. Review of these data suggests that this approach might lead to novel therapeutic strategies in rheumatoid arthritis and other chronic inflammatory disorders.
Keywords: chemokines, rheumatoid arthritis, synovial tissue
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