Search tips
Search criteria 


Logo of iaiPermissionsJournals.ASM.orgJournalIAI ArticleJournal InfoAuthorsReviewers
Infect Immun. Aug 1979; 25(2): 580–582.
PMCID: PMC414484
Exposure of guinea pigs to Rickettsia rickettsii by aerosol, nasal, conjunctival, gastric, and subcutaneous routes and protection afforded by an experimental vaccine.
R H Kenyon, R A Kishimoto, and W C Hall
Guinea pigs were inoculated with Rocky Mountain spotted fever by the aerosol, conjunctival, subcutaneous, intragastric, and intranasal routes. Rickettsial infection was produced by all routes except intragastric. All animals with clinical signs of disease developed agglutinating antibody, and most developed a cell-mediated immune response. Disease produced by all experimental routes (except intragastric) was indistinguishable. The tissue culture-derived inactivated vaccine produced in this laboratory protected guinea pigs against an aerosol challenge.
Full text
Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (465K), or click on a page image below to browse page by page.
Articles from Infection and Immunity are provided here courtesy of
American Society for Microbiology (ASM)