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Logo of nihpaAbout Author manuscriptsSubmit a manuscriptHHS Public Access; Author Manuscript; Accepted for publication in peer reviewed journal;
J Thorac Oncol. Author manuscript; available in PMC 2014 March 24.
Published in final edited form as:
PMCID: PMC3963390

Imaging During Radiation Therapy Captures Abrupt and Dramatic Changes

Feng-Ming (Spring) Kong, M.D., Ph.D., Kakit Wong, M.D., and Timothy Ritter, Ph.D

A 53 year-old woman with non-small cell lung cancer of the left upper lobe (LUL) was treated with radiation and concurrent chemotherapy. The initial baseline 18-fluorodeoxyglucose positron emission tomography (FDG-PET) and computed tomography (CT) scans (left panels) displayed an FDG-avid LUL mass, a positive left pretracheal node, atelectasis of the LUL, and minimal FDG activity in the esophagus. Repeat CT and PET scans (middle panels) on day 39, following a 44 Gy tumor dose, revealed minimal activity in the pretracheal node, reduced LUL tumor activity and size, persistence of the LUL atelectasis, and increased esophageal activity. Three days later an on-treatment cone beam CT (upper right panel, CT3*) showed remarkable posterior-lateral translation of the primary tumor and complete resolution of the LUL atelectasis. Repeat CT (not shown) and PET (PET3) confirmed the cone beam CT findings and demonstrated increased esophageal activity consistent with clinical symptoms of radiation esophagitis. The abrupt resolution of atelectasis and dramatic tumor shift, demonstrated in the co-registered PET image showing a fusion of the 2nd and 3rd PET images, mandated substantial changes to the treatment. Without adaptive planning, a highly conformal treatment plan would have missed a portion of the shifted target volume. With advanced radiation delivery methods and small treatment margins the possibility of a geometric miss due to such a shift is high. Similar tumor and anatomic re-modeling may go undetected unless frequent imaging is performed during treatment, especially when the patient’s normal anatomy is drastically altered by disease. In such cases a daily cone beam CT may be warranted. This finding provides further justification for the RTOG1106/ACRIN6697 trial, which will test whether during-treatment PET and CT based individualized adaptive radiation planning enables improved local regional tumor control in non-small cell lung cancer.

Figure 1
CT and 18-FDG PET images obtained at three time points during radiation therapy.
Figure 2
A composite image showing a fusion of the 2nd and 3rd PET images.


The primary author has received funding through an NIH RO1 grant.


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