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Common pathogens of clinically mild encephalitis/encephalopathy with a reversible splenial lesion (MERS) are viruses, such as influenza virus. However, bacteria are rare pathogens for MERS. We report the first patient with MERS associated with febrile urinary tract infection. A 16-year-old lupus patient was admitted to our hospital. She had fever, headache, vomiting, and right back pain. Urinary analysis showed leukocyturia, and urinary culture identified Klebsiella pneumoniae. Cerebrospinal fluid examination and brain single-photon emission computed tomography showed no abnormalities. Therefore, she was diagnosed with febrile urinary tract infection. For further examinations, 99mTc-dimercaptosuccinic acid renal scintigraphy showed right cortical defects, and a voiding cystourethrogram demonstrated right vesicoureteral reflux (grade II). Therefore, she was diagnosed with right pyelonephritis. Although treatment with antibiotics administered intravenously improved the fever, laboratory findings, and right back pain, she had prolonged headaches, nausea, and vomiting. T2-weighted, diffusion-weighted, and fluid attenuated inversion recovery images in brain magnetic resonance imaging showed high intensity lesions in the splenium of the corpus callosum, which completely disappeared 1 week later. These results were compatible with MERS. To the best of our knowledge, our patient is the first patient who showed clinical features of MERS associated with febrile urinary tract infection. Conclusion: In patients with pyelonephritis and an atypical clinical course, such as prolonged headache, nausea, vomiting, and neurological disorders, the possibility of MERS should be considered.
Clinically mild encephalitis/encephalopathy with a reversible splenial lesion (MERS) is characterized by magnetic resonance imaging (MRI) of a reversible isolated lesion with transiently reduced diffusion in the splenium of the corpus callosum . The most common clinical manifestation is a neurological disorder, such as delirious behavior, consciousness disturbance, and seizures. Most patients with MERS clinically recover completely within 1 month . Influenza virus types A and B are the most common pathogens of MERS. However, bacterial infection has also been reported as pathogens in a few patients with MERS and not in patients with other classifications of acute encephalopathy, such as acute necrotizing encephalopathy and acute encephalopathy with biphasic seizures and late reduced diffusion . We report here the first patient with MERS associated with febrile urinary tract infection.
A 15-year-old Japanese girl was admitted to the hospital with severe periorbital and pedal edema. She also had a butterfly shadow, oral ulcer, and joint pain. A peripheral blood examination showed thrombocytopenia (platelets, 66×109/l), hypoproteinemia (serum total protein, 33 g/l), hypoalbuminemia (serum albumin, 6 g/l), and hypercholesterolemia (total cholesterol, 13 mmol/l). Her serum creatinine level was normal (41.5 μmol/l). Immunological studies were positive for anti-nuclear antibody with a titer of 1:640 in a peripheral pattern, anti-smooth muscle antibody of 0.22 U/l (normal range, 0.0–0.0059 U/l), anti-U1 ribonucleic protein antibody of 0.15 U/l (normal range, 0.0–0.012 U/l), and anti-single-stranded DNA antibody of 0.035 U/l (normal range, 0–0.025 U/l). Serum complement levels were low, with C3 of 0.49 g/l (normal range, 0.86–1.6 g/l), C4 of 0.1 g/l (normal range, 0.17–0.45 g/l), and CH50 of 22.3 kU/l (normal range, 31.5–48.4 kU/l). Sediment contained 20–29 red blood cells and cellular casts per high-power field, and urinalysis showed proteinuria at a concentration of 34,010 g/l and urinary protein to creatinine ratio of 27 g/gCr. Based on these findings, she was diagnosed with systemic lupus erythematosus (SLE) with nephrotic syndrome. Renal biopsy findings showed a minor glomerular abnormality under light microscopy. By immunofluorescence study, granular depositions of IgG and C3 along the peripheral capillaries were observed, and electron microscopy showed subepithelial deposits. With prednisolone and tacrolimus, she achieved complete remission after 8 months.
At the age of 16 years, the patient had fever, headache, vomiting, and right back pain. One day later, she had chills and delirious behavior followed by consciousness disturbance. On admission, the patient was awake but appeared severely ill owing to malaise and dehydration. Her blood pressure was 87/45 mmHg, pulse was 89 beats per minute, temperature was 39.5 °C, and oxygen saturation was 98 % while she was breathing ambient air. Her abdominal pain was localized to the right back region, and costovertebral angle tenderness was positive. Peripheral blood analysis showed leukocytosis (white blood cell count, 18×109/l), an elevated C-reactive protein level of 0.17 g/l (normal range, 0.0–0.0039 g/l), and serum creatinine level of 78.6 μmol/l. Complement levels were normal. Urinary sediments contained 10–19 white cells, and urinary culture was positive for Klebsiella pneumoniae. Cerebrospinal fluid (CSF) examination showed no abnormalities, and cultures of blood and CSF were negative. In addition, brain single-photon emission computed tomography showed no abnormalities. Therefore, it was thought that flaring of lupus was unlikely, and she was diagnosed with febrile urinary tract infection. Further examinations, including a voiding cystourethrogram (VCUG) and 99mTc-dimercaptosuccinic acid (DMSA) renal scintigraphy, were performed. VCUG showed right vesicoureteral reflux (grade II), and 99mTc-DMSA scintigraphy showed right cortical defects. These results were compatible with right pyelonephritis. Thereafter, treatment with intravenous antibiotics gradually improved signs and symptoms, such as fever, laboratory findings, and right back pain, but she had prolonged headaches, nausea, and vomiting. Therefore, further examinations were performed. As a result, T2-weighted, diffusion-weighted, and fluid attenuated inversion recovery images in brain MRI showed high intensity lesions in the splenium of the corpus callosum on the third hospital day, which completely disappeared 1 week later (Fig. 1). At the same time, headaches, nausea, and vomiting also gradually improved. These typical findings of MRI and clinical features were compatible with MERS.
At the age of 17 years, the patient has not had recurrence of MERS with sustained remission of lupus.
To the best of our knowledge, our patient is the first patient who showed clinical features of MERS associated with a febrile urinary tract infection. Furthermore, this report is also the first to show an association between MERS and K.pneumonia infection. The major pathogens of MERS are viruses, such as influenza virus (A and B), mumps virus, adenovirus, and rotavirus (Table 1). However, bacteria are also known as pathogens, which account for 3.3 % of all causes of MERS . Streptococci and Escherichia coli have been reported as bacterial pathogens of MERS . Because bacterial pathogens have not been identified in acute necrotizing encephalopathy and acute encephalopathy with biphasic seizures and late reduced diffusion cases, further research on bacterial pathogens of MERS is required for understanding the etiology and pathogenesis of MERS.
About the pathogenesis of MERS, there are several hypotheses such as intramyelinic edema, hyponatremia, axonal damage, and oxidative stress [6, 8, 10, 12]. However, the exact reason for the development of MERS in patients with bacterial infection, as well as our patient, is unknown. Serum proinflammatory cytokines, including interleukin (IL)-1β, IL-6, and IL-8, and tumor necrosis factor-alpha are elevated in patients with acute pyelonephritis [4, 9], and Kawasaki disease, by which MERS is also complicated . Therefore, activation of the immune system is likely to be associated with the pathogenesis of MERS. Although our patient did not appear to have flaring of lupus, lupus was possibly associated with the pathogenesis of MERS in our patient because the pathogenesis of SLE also appears to be associated with activation of the immune system and oxidative stress [2, 14].
Because of the prolonged headaches, nausea, and vomiting, further examinations were carried out following detection of MERS in our patient. In patients with acute pyelonephritis, clinical findings included varied gastrointestinal signs and symptoms, such as diarrhea, vomiting, and nausea . Furthermore, neurological manifestations, such as irritability and seizures, are also possible clinical findings in pyelonephritis . Therefore, at the onset, it is difficult to determine whether there are typical clinical findings in pyelonephritis or complications of MERS in patients with pyelonephritis. However, if gastrointestinal and neurological features are prolonged after improving pyelonephritis, clinicians should consider the possibility of MERS.
We would like to thank Dr. Kohsuke Kudo and Dr. Hideaki Shiraishi for their contribution to diagnosis and management of our patient.
The authors declare no conflict of interest.