Behavioral analysis of working memory. Mean (± SE) number of working memory incorrect errors for each trial committed on the water radial maze for normally fed and high fat fed C57BL/6 mice were determined as described under Methods. B. Working memory incorrect ± SE for each treatment group i.e., C57BL/6 and LDLR−/− mice fed either normal or high fat diet. * p < 0.05 versus the normally (basal diet) fed control group. # represents significant (p < 0.05) difference of normally fed LDLR−/− group from normally fed C57BL/6 (control) group.