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Logo of thijTexas Heart Institute JournalSee also Cardiovascular Diseases Journal in PMCSubscribeSubmissionsTHI Journal Website
Tex Heart Inst J. 2004; 31(1): 105.
PMCID: PMC387446

Aspartame Disease

A Possible Cause for Concomitant Graves' Disease and Pulmonary Hypertension
H. J. Roberts, MD, FACP, FCCP

To the Editor:

In a recent issue of the Texas Heart Institute Journal, Virani and co-authors. 1 reported the cases of 2 women, ages 38 and 40, with concomitant Graves' disease and pulmonary hypertension. They also cited 5 reports in the literature since 1999 concerning this combination of conditions.

I have written about aspartame disease for more than 2 decades, because of the profound adverse neurologic, cardiopulmonary, endocrine, and allergic effects of aspartame products. 2,3 These “diet” sodas, along with thousands of other products containing aspartame, are currently being consumed by an estimated 70% of the population. My own database exceeds 1,300 victims of aspartame-related illnesses, with a 3:1 preponderance of women—a difference that is germane to the disorders under consideration.

My 1st report on aspartame-related Graves' disease. 4 described 4 weight-conscious women with hyperthyroidism who experienced dramatic remissions within several weeks to 3 months of avoiding aspartame. Four other women who had been treated previously for Graves' disease developed symptoms suggestive of this condition within a few weeks to 6 months after beginning aspartame consumption; symptoms subsided after cessation. These symptoms promptly recurred (generally within 2 days) on multiple rechallenges. The number of patients in this series has doubled since the initial report.

The problem of aspartame-induced pulmonary hypertension was raised by a 27-year-old woman with severe dyspnea and other features attributable to aspartame disease who was found to have primary pulmonary hypertension at autopsy. 5 This association assumed increased relevance because of my database, which revealed that dyspnea was a major symptom in 110 of 1,200 persons (9%) who reacted to aspartame products. In no case could the dyspnea be attributed to a known heart or lung disorder. Most of the patients were weight-conscious women in their 20s to 40s, who experienced marked improvement after avoiding aspartame. Their dyspnea promptly recurred after rechallenge, both upon self-challenge and upon in advertent exposure.

Aspartame consists of the amino acids phenylalanine (50%), aspartic acid (40%), and a methyl ester (10%) that promptly becomes free methanol after entering the stomach. 3 The breakdown of phenylalanine to highly vasoactive substances—such as dopamine, norepinephrine, and epinephrine—is clearly relevant to pulmonary hypertension, systemic hypertension, and the frequent cardiac arrhythmias experienced by persons with aspartame disease. In my opinion, potent new drugs aimed at reducing pulmonary hypertension should be administered in a patient consuming these products only after a trial of aspartame abstinence.


Letters to the Editor should be no longer than 2 double-spaced typewritten pages and should contain no more than 4 references. They should be signed, with the expectation that the letters will be published if appropriate. The right to edit all correspondence in accordance with Journal style is reserved by the editors.


1. Virani SS, Mendoza CE, Ferreira AC, de Marchena E. Graves' disease and pulmonary hypertension: report of 2 cases. Tex Heart Inst J 2003;30:314–5. [PMC free article] [PubMed]
2. Roberts HJ. Aspartame (NutraSweet®): is it safe? Philadelphia: The Charles Press; 1989.
3. Roberts HJ. Aspartame disease: an ignored epidemic. West Palm Beach: Sunshine Sentinel Press; 2001.
4. Roberts HJ. Aspartame and hyperthyroidism: a presidential affliction reconsidered. Townsend Letter for Doctors & Patients 1997;May:86–8.
5. Roberts HJ. Aspartame-induced dyspnea and pulmonary hypertension. Townsend Letter for Doctors & Patients 2003; January:64–5.

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