PMCCPMCCPMCC

Search tips
Search criteria 

Advanced

 
Logo of dmJournal's HomeManuscript SubmissionAims and ScopeAuthor GuidelinesEditorial BoardHome
 
Dis Markers. 2006; 22(5-6): 343–349.
Published online 2007 January 26. doi:  10.1155/2006/951857
PMCID: PMC3851375

Genome Wide Screening of CAG Trinucleotide Repeat Lengths in Breast Cancer

Hamdi Jarjanazi, 1 , 2 Hong Li, 1 Irene L. Andrulis, 1 , 2 , 3 and Hilmi Ozcelik 1 , 2 ,*

Abstract

Trinucleotide repeat sequences are widely present in the human genome. The expansion of CAG repeats have been studied very extensively, and shown to be the causative mechanism of more than 40 neuromuscular and neurodegenerative diseases. In the present study, we performed a genome wide screening of CAG repeat expansions in non-neoplastic tissues of 212 breast cancer cases and 196 healthy population controls using the Repeat Expansion Detection (RED) method. Distribution of CAG repeat lengths in cases was not significantly different from controls. However, dramatically expanded CAG repeats were detected in 2.4% (n = 5) of breast cancer cases where no repeats of similar size were detected in any of the healthy population controls. Although this trend shows only borderline significance (p = 0.06), this finding suggests a potential involvement of CAG repeat expansion in breast cancer susceptibility. These repeats may potentially affect the function of cancer predisposition genes, with a similar mechanism as in neurodegenerative and neuromuscular disorders.

Keywords: Breast cancer, CAG repeats, rapid expansion detection, trinucleotide repeat expansions

Articles from Disease Markers are provided here courtesy of Hindawi Publishing Corporation