© 2013 Fesinmeyer et al.; licensee BioMed Central Ltd.
Genetic variants associated with fasting glucose and insulin concentrations in an ethnically diverse population: results from the Population Architecture using Genomics and Epidemiology (PAGE) study
1Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle WA, USA
2General Medicine Division, Department of Medicine, Harvard Medical School, Boston MA, USA
3Carolina Center for Genome Sciences, School of Public Health, University of North Carolina, Chapel Hill, NC, USA
4Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
5Department of Preventive Medicine, Keck School of Medicine / Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA
6Department of Biostatistics, University of Washington, Seattle, WA, USA
7Center for Human Genetics Research, Vanderbilt University Medical Center, Nashville, TN, USA
8Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX, USA
9MedStar Research Institute, Georgetown University, Hyattsville, MD, USA
10Department of Internal Medicine, Ohio State Medical Center, Columbus, OH, USA
11Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI, USA
12Department of Epidemiology, University of California, Los Angeles, CA, USA
13Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA
14Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
15Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA, USA
16Department of Genetics, Rutgers University, Piscataway, NJ, USA
17Information Sciences Institute, University of Southern California, Marina del Rey, CA, USA
18Department of Statistics & Biostatistics, Rutgers University, Piscataway, NJ, USA
19Office of Population Genomics, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA
20Division of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis MN, USA
Received December 4, 2012; Accepted September 10, 2013.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0
), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
The data and materials included in this report result from a collaboration between the following studies:
The "Epidemiologic Architecture for Genes Linked to Environment (EAGLE)" is funded through the NHGRI PAGE program (U01HG004798-01 and its NHGRI ARRA supplement). Genotyping services for select NHANES III SNPs presented here were also provided by the Johns Hopkins University under federal contract number (N01-HV-48195) from NHLBI. The study participants derive from the National Health and Nutrition Examination Surveys (NHANES), and these studies are supported by the Centers for Disease Control and Prevention. The findings and conclusions in this report are those of the authors and do not necessarily represent the views of the Centers for Disease Control and Prevention.
The Multiethnic Cohort study (MEC) characterization of epidemiological architecture is funded through the NHGRI PAGE program (U01HG004802 and its NHGRI ARRA supplement). The MEC study is funded through the National Cancer Institute (R37CA54281, R01 CA63, P01CA33619, U01CA136792, and U01CA98758).
Funding support for the "Epidemiology of putative genetic variants: The Women’s Health Initiative" study is provided through the NHGRI PAGE program (U01HG004790 and its NHGRI ARRA supplement). The WHI program is funded by the National Heart, Lung, and Blood Institute, National Institutes of Health, U.S. Department of Health and Human Services through contracts HHSN268201100046C, HHSN268201100001C, HHSN268201100002C, HHSN268201100003C, HHSN268201100004C, and HHSN271201100004C. The authors thank the WHI investigators and staff for their dedication, and the study participants for making the program possible. A full listing of WHI investigators can be found at: https://cleo.whi.org/researchers/Documents%20%20Write%20a%20Paper/WHI%20Investigator%20Long%20List.pdf
Funding support for the Genetic Epidemiology of Causal Variants Across the Life Course (CALiCo) program was provided through the NHGRI PAGE program (U01HG004803 and its NHGRI ARRA supplement). The following studies contributed to this manuscript and are funded by the following agencies: The Atherosclerosis Risk in Communities (ARIC) Study is carried out as a collaborative study supported by National Heart, Lung, and Blood Institute contracts N01-HC-55015, N01-HC-55016, N01-HC-55018, N01-HC-55019, N01-HC-55020, N01-HC-55021, N01-HC-55022. The Cardiovascular Health Study (CHS) is supported by contracts HHSN268201200036C, N01-HC-85239, N01-HC-85079 through N01-HC-85086, N01-HC-35129, N01 HC-15103, N01 HC-55222, N01-HC-75150, N01-HC-45133, and grant HL080295 from the National Heart, Lung, and Blood Institute (NHLBI), with additional contribution from the National Institute of Neurological Disorders and Stroke (NINDS). Additional support was provided through AG-023629, AG-15928, AG-20098, and AG-027058 from the National Institute on Aging (NIA). The Strong Heart Study (SHS) is supported by NHLBI grants U01 HL65520, U01 HL41642, U01 HL41652, U01 HL41654, and U01 HL65521. The opinions expressed in this paper are those of the author(s) and do not necessarily reflect the views of the Indian Health Service.
Assistance with phenotype harmonization, SNP selection and annotation, data cleaning, data management, integration and dissemination, and general study coordination was provided by the PAGE Coordinating Center (U01HG004801-01 and its NHGRI ARRA supplement). The National Institutes of Mental Health also contributes to the support for the Coordinating Center.
The PAGE consortium thanks the staff and participants of all PAGE studies for their important contributions.