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Appl Microbiol. 1969 August; 18(2): 159–165.
PMCID: PMC377936

Antibacterial Activity of 2′-Esters of Erythromycin

Abstract

The effect of esterification at the 2′-position of desosamine on the antibacterial activity of erythromycin was investigated by determining the bacteriostatic and bactericidal activities of erythromycin and a number of its 2′-esters on S. aureus and relating these activities to the hydrolysis rates of the esters. These studies, together with comparison of the inhibition of protein synthesis in a cell-free system isolated from S. aureus, lead to the conclusion that 2′-esters of erythromycin are inactive until hydrolyzed. Loss of activity appears to result from inability of erythromycin esters to bind to bacterial ribosomes and thus inhibit synthesis of protein.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Mao JC. Protein synthesis in a cell-free extract from Staphylococcus aureus. J Bacteriol. 1967 Jul;94(1):80–86. [PMC free article] [PubMed]
  • Mao JC. The stoichiometry of erythromycin binding to ribosomal particles of Staphylococcus aureus. Biochem Pharmacol. 1967 Dec;16(12):2441–2443. [PubMed]
  • Mao JC, Wiegand RG. Mode of action of macrolides. Biochim Biophys Acta. 1968 Apr 22;157(2):404–413. [PubMed]
  • TAUBMAN SB, SO AG, YOUNG FE, DAVIE EW, CORCORAN JW. EFFECT OF ERYTHROMYCIN ON PROTEIN BIOSYNTHESIS IN BACILLUS SUBTILIS. Antimicrob Agents Chemother (Bethesda) 1963;161:395–401. [PubMed]
  • Wilhelm JM, Oleinick NL, Corcoran JW. Interaction of antibiotics with ribosomes: structure-function relationships and a possible common mechanism for the antibacterial action of the macrolides and lincomycin. Antimicrob Agents Chemother (Bethesda) 1967;7:236–250. [PubMed]

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