Search tips
Search criteria 


Logo of applmicroPermissionsJournals.ASM.orgAEM ArticleJournal InfoAuthorsReviewers
Appl Microbiol. 1970 August; 20(2): 215–217.
PMCID: PMC376903

Product Inhibition of the Fermentative Formation of Glutamic Acid


The addition of penicillin to cells of Corynebacterium glutamicum growing in 5-liter fermentors initiated the excretion of glutamic acid. The rate of glutamate production in fermentors declined continuously with time and reached 75% of the initial rate in 24 hr after penicillin had been added. The addition of glutamate to resting cell suspensions had only a slight effect on sugar utilization but caused a marked decrease in glutamate excretion. It is suggested that the high level of glutamate accumulating in the fermentation broth is responsible for inhibiting its own production.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (410K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Birnbaum J, Demain AL. Reversal by citrate of the iodoacetate and fluoride inhibition of glutamic acid production by Corynebacterium glutamicum. Appl Microbiol. 1969 Aug;18(2):287–288. [PMC free article] [PubMed]
  • Demain AL, Birnbaum J. Alteration of permeability for the release of metabolites from the microbial cell. Curr Top Microbiol Immunol. 1968;46:1–25. [PubMed]
  • Flechtner VR, Hanson RS. Coarse and fine control of citrate synthase from Bacillus subtilis. Biochim Biophys Acta. 1969 Jul 30;184(2):252–262. [PubMed]
  • Hanson RS, Cox DP. Effect of different nutritional conditions on the synthesis of tricarboxylic acid cycle enzymes. J Bacteriol. 1967 Jun;93(6):1777–1787. [PMC free article] [PubMed]
  • Varricchio F. Control of glutamate dehydrogenase synthesis in Escherichia coli. Biochim Biophys Acta. 1969 May 6;177(3):560–564. [PubMed]

Articles from Applied Microbiology are provided here courtesy of American Society for Microbiology (ASM)