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Int J Surg Case Rep. 2013; 4(5): 473–476.
Published online 2013 February 19. doi:  10.1016/j.ijscr.2013.02.003
PMCID: PMC3731718

A peculiar cause of bowel obstruction

Abstract

INTRODUCTION

Gallstone disease is one of the most common surgical problems necessitating intervention. It is estimated that approximately 15% of people in the western world will develop gallstones. Of these patients, 35% of patients initially diagnosed with gallstones will later develop a complication which will eventually result in cholecystectomy.2

One of these complications is gallstone ileus, which is a rare complication associated with high morbidity and mortality, and the diagnosis is often missed.3

PRESENTATION OF CASE

A 66 year old female presented with an acute onset of “colicky” abdominal pain accompanied with vomiting. She had known gallstones diagnosed previously by ultrasound. Her abdomen was generally tender with guarding of the right hypochondrium and absent bowel sounds.

DISCUSSION

Gallstone ileus accounts for 0.5–4% of all cases of small bowel obstruction, and typically affects females over the age of 65.3,4 The pathophysiological basis of the disease involves fistulation of the gallstone through the wall of the gallbladder into the bowel, where it becomes impacted and leads to obstruction. Mortality of the condition is not sufficiently reported, but surgical intervention in itself conveys significant morbidity, and mortality has been reported to be 18%.3,9

CONCLUSION

We report a single large gallstone, which we believe to be one of the largest documented in recent literature, resulting in gallstone ileus. We also present a brief synopsis of the diagnosis and management of the condition, which although rare, should be considered by the astute surgical trainee.

Keywords: Acute abdomen, Ileus, Gallstones, Diagnosis and management

1. Introduction

Gallstone disease is one of the most common surgical problems necessitating intervention. Indeed, in 2003–2005, there were 25,743 emergency admissions with acute gall bladder disease in the UK, 56% of which had biliary colic and 36% had acute cholecystitis.1 It is estimated that approx 15% of people in the western world will develop gallstones. Factors affecting their prevalence include increasing age, female sex, obesity, diabetes, pregnancy, increased oestrogen exposure, haemolytic disease and cirrhosis. It is thought that approximately 35% of patients initially diagnosed with gallstones will later develop a complication, which will eventually result in cholecystectomy.2

The following case report and discussion highlights a rare complication of gallstone disease and its management, which conveys a significant increase in morbidity and mortality.

2. Presentation of case

A 66 year old female presented with a two day history of right upper quadrant pain, colicky central abdominal pain and a 24-h history of vomiting. She had a previous diagnosis of gallstones on ultrasound, but was otherwise fit and healthy. There had been no previous hospital admissions and she had remained otherwise asymptomatic until this presentation.

On examination she was pyrexic, tachycardic and hypotensive with no obvious jaundice. The abdomen was distended and tympanic with generalised tenderness and guarding in the right upper quadrant. Bowel sounds were decreased. Digital rectal examination was normal.

Blood investigations revealed a white cell count of 14.7, CRP of 23. Erect chest X-ray revealed no free air under the diaphragm and abdominal X-ray showed dilated small bowel loops in keeping with small bowel obstruction, and an opacity in the right iliac fossa.

A CT scan of abdomen and pelvis was carried out to ascertain the cause of the obstruction. The scan revealed pneumobilia (Fig. 1) and a large gallstone in the area of the terminal ileum (Figs. 2 and 3), in keeping with gallstone ileus.

Fig. 1
Pneumobilia can be seen within the hepatic tissues on the CT scan.
Fig. 2
A gallstone can be seen in the terminal ilium with dilated loops of fluid filled small bowel indicating obstruction.
Fig. 3
Sagittal view of the gallstone in the terminal ilium. It gives a characteristic target appearance.

At laparotomy, the small bowel was found to be dilated. The terminal ileum was identified and an enterolithotomy performed with the removal of a large gallstone measuring 7 cm in length (Fig. 4).

Fig. 4
The gallstone after delivery via an enterolithotomy. Maximum diameter was approximately 7 cm.

Post operatively she made a good recovery and was discharged home on day nine.

3. Discussion

Gallstone ileus is a rare complication of gallstone disease, commonly observed in females over the age of 65,4 and accounts for 0.4–5% of all cases of small bowel obstruction. Biliary enteric fistulae are a rare but well recognised complication of cholelithiasis, and was first described by Courvoisier.5 The pathological processes involved in the formation of the cholecystoenteric fistula are that of chronic cholelithiasis, inflammation and adhesion with the gastrointestinal tract. This in turn facilitates erosion of the gallstone into the adjacent hollow viscus, with eventual passage of the gallstone into the gut.6,7 The site at which impaction occurs, and the size required for a gallstone to produce ileus varies considerably. Whilst impaction can occur anywhere within the gastrointestinal tract, impaction commonly occurs at the relatively narrow terminal ileum when the stone is greater than 2.5 cm in diameter.8 The largest recorded stone was 17.7 cm in maximum diameter and was described by Grey-Turner in 1932.9 The size of the stone and the luminal diameter are the two main determining factors of impaction.6

Rigler described a triad for diagnosis of gallstone ileus which is characterised by the association of an ectopic gallstone, partial or complete bowel obstruction, and gas in the gallbladder or the biliary tree.10

There are a series of case reports in the literature describing large gallstones resulting in ileus, and although a rare cause, it is a diagnosis that was often missed before the advent of ultrasound and CT scanning,11 the virtues of the latter being demonstrated in this case. The most common site of impaction is at the distal small bowel.Plain films remain the first step in the evaluation of patients with suspected gallstone ileus. Features include signs of bowel obstruction, a calcified stone within the bowel lumen and pneumobilia. Sensitivity of X-ray varies from 40 to 70%.12 Pneumobilia is present in only one third of cases and recognition of gallstones in the intestinal lumen depends upon the density of calcium in the stone.10,11 Other diagnostic tools include fistulography, endoscopic retrograde cholangiopancreatography, PTC and operative cholecystography.13–15

Optimal treatment of gallstone ileus with fistula formation is challenging and controversial, owing to the therapeutic challenges and the low incidence of the disease itself. Only a few cases have been reported in the literature regarding the management of the most commonplace abnormality – cholecystoduodenal fistula.16,17 Conservative management of cholecystoenteric fistula without obstruction can be employed with the administration of fluid and electrolyte replacement, antibiotic therapy, nasobiliary drainage and endoscopic sphincterotomy, with removal of further gallstones with or without stenting.13 This follows the mantra of the principles of fistula management – addressing Sepsis, Nutrition, Anatomical consideration, and interventional Procedure (the “SNAP” mnemonic). Prognosis of these fistulae is good, with less than a 10% risk of mortality.10

The presence of gallstone ileus with complete obstruction is an absolute indication for emergency surgical intervention.

Surgical treatment is either by a one stage, or a two stage technique. Enterolithotomy alone is the most common treatment option. The one stage procedure involves enterolithotomy, cholecystectomy and fistula repair.

The two stage consists of enterolithotomy with biliary repair at a later stage, and is the more commonplace procedure offered in the emergency setting,18 with conservative management continuing until the patient is optimised to undergo take-down of the fistula, and closure. Usually the cholecystoenteric fistula is large, and therefore recurrent complications are rare, and many often close spontaneously owing to their low output states.19,20 Possible complications however, include electrolyte disturbance, fat malabsoprtion syndrome, cholangitis, recurrent ileus, and increased risk of gallbladder cancer.13,18,19

The decision to undertake a one-stage or two-stage procedure remains under debate. Proponents of the one stage technique feel it is associated with reduced morbidity as it reduces the risk of recurrence, but studies have illustrated increased mortality rates of 15–18% versus 11.7% for enterolithotomy alone.3,21 Studies have also found a higher rate of complications associated with the one stage procedure, with complication rates reported to be 27% versus 61% in one study.22 Ultimately, the condition of the patient will determine the operative course. Therefore, the two stage technique may be advocated in those who are profoundly unstable as a result of the pathological process underlying the condition, while the one stage procedure should be used in selected cases only.7,23–25 The range in mortality rates may be accounted for by the elderly patient population in which the illness occurs, the delay in diagnosis and existing comorbid states. A recent study by Tan however, suggested that there was no significant difference in mortality between the two procedures, but acknowledged that whilst gallstone ileus remained rare, no gold standard treatment existed as yet.26 Recently, much interest has been expressed in the field of laparoscopic treatment of cholecystoenteric fistulas. Whilst technically more demanding, no large scale study exists to prove its superiority.20,27

Our patient underwent a one stage procedure with no complications. She was discharged day 9 post operatively. At 6 month follow up the patient was alive and well.

4. Conclusion

A diagnosis of gallstone ileus should be suspected in elderly females with a history of cholelithiasis, who present with symptoms of small bowel obstruction with no evidence of previous abdominal surgery. CT remains the gold standard for diagnosis of the condition, and delayed diagnosis results in an increased mortality.3 Optimal management remains debatable, but definitive intervention must be on an individualised basis, with enterolithotomy alone being appropriate in the emergent setting, and the one stage technique being employed in selected patients only.

Conflict of interest

None.

Funding

None.

Consent

Written informed consent was obtained from the patient for publication of this case report and accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal on request.

The paper was written in full by Mr Adam Tucker, and was reviewed by Mr Ian Garstin. We, the authors declare no conflict of interest for the attached report.

References

1. Sanders G., Kingsnorth A.N. Gallstones. British Medical Journal. 2007;11;335(7614):295–299. [PMC free article] [PubMed]
2. Schirmer B.D., Winters K.L., Edlich R.F. Cholelithiasis and cholecystitis. Journal of Long-Term Effects of Medical Implants. 2005;15(3):329–338. [PubMed]
3. Abbas M., Bhat N. Gall stone ileus: a rare complication of gallstone disease. Case Report and Literature Review Internet Journal Of Surgery. 2009;21(1) http://www.ispub.com/journal/the_internet_journal_of_surgery/volume_21_number_1_1/article_printable/gall-stone-ileus-a-rare-complication-of-gallstone-disease-case-report-and-literature-review-1.html.
4. Casparrini M., Liverani A., Catracchia V., Conte S., Leonardo G., Marino G. Gallstone ileus: a case report and review of the literature. Chirurgia Italiana. 2008;60(5 (September–October)):755–759. [PubMed]
5. Courvoisier L.T. FCW Vogel; Leipzig: 1890. Zasurstitsch-Statistiche Beitrage Zur Pathologie Und Chirurgie Der Gallenwegg.
6. Ayantunde A.A., Agrawal A. Gallstone ileus: diagnosis and management. World Journal of Surgery. 2007;31:1291–1297. [PubMed]
7. Pavlidis T.E., Atmatzidis K.S., Papaziogas B.T. Management of gallstone ileus. Journal of Hepato-Biliary-Pancreatic Surgery. 2003;10:299–302. [PubMed]
8. Beuran M., Ivanov I., Venter M.D. Gallstone ileus – clinical and therapeutic aspects. Journal of Medicine and Life. 2010;3(4):365–371. [PubMed]
9. Grey-Turner G. A giant gallstone impacted in the colon causing acute obstruction. British Journal of Surgery. 1932;20:26.
10. Rigler L.G., Borman C.N., Noble J.F. Gallstone obstruction: pathogenesis and roentgen manifestations. The Journal of the American Medical Association, Chicago. 1941;117:1753–1759.
11. Browning L.E. Jejunal perforation in gallstone ileus – a case series. Journal of Medical Case Reports. 2007;1:157. [PubMed]
12. Maglinte D.D., Reyes B.L., Harmon B.H., Kevlin F.M. Reliability and role of plain film radiography and CT in the diagnosis of small-bowel obstruction. American Journal of Roentgenology. 1996;167:1451. [PubMed]
13. Yean Y.S., Fu Y.T., Kao C.C. Cholecyto-enteric fistula. Journal of Medical Sciences. 2004;24(5):279–282.
14. Wong S.K., Lam Y.H., Lau J.Y. Diagostic and therapeutic fistuloscopy: an adjuvant management in postoperative fistulas and abscess after upper gastrointestinal surgery. Endoscopy. 2000;32:311–313. [PubMed]
15. Kalimi R., Cosgrove J.M., Marini C. Combined intraoperative laparoscopic cholecystectomy and endoscopic retrograde cholangiopancreatography. Lessons from 29 cases. Surgical Endoscopy. 2000;14:232–234. [PubMed]
16. Singh N., Stempel K. Cholecystoduodenal fistula. The New England Journal of Medicine. 1997;336:266. [PubMed]
17. Stern S., Singh S., Thakur M. Cholecystoduodenal fistula gastrointestinal. Endoscopy. 2006;154:155. [PubMed]
18. Vagefi P.A., Ferguson C.M., Hall J.F. Recurrent gallstone ileus: third time is the charm. Archives of Surgery. 2008;143(11):1118–1120. [PubMed]
19. Reisner R.M., Cohen J.R. Gallstone ileus: a review of 1001 reported cases. American Surgeon. 1994;60:441–446. [PubMed]
20. Leone V. Gallstone Ileus: diagnostic and surgical dilemma. Journal of Current Surgery. 2012;2(3):84–88.
21. Zuegal N. Advantages of one stage repair in gallstone ileus. Hepato-Gastroenterology. 1997;44:59–62. [PubMed]
22. Doko M., Zovak M., Kopljar M., Glavan E., Ljubicic N., Hochstädter H. Comparison of surgical treatments of gallstone ileus: preliminary report. World Journal of Surgery. 2003;27:400–404. [PubMed]
23. Muthukaramasamay G., Venkata S.P., Shaikh I.A. Gallstone ileus: surgical strategies and clinical outcome. Journal of Digestive Diseases. 2008;9(3):156–161. [PubMed]
24. Riaz N., Khan M.R., Tayeb M. Gallstone ileus: retrospective review of a single centres experience using two surgical procedures. Singapore Medical Journal. 2008;49(8):624–626. [PubMed]
25. Corvera CU, Jarnagin WR, Blumgart LH. In: Blumgart's surgery of the liver, pancreas and biliary tract. 5th ed., vol. 1. [Chapter 42B: Biliary Fistulae]. Saunders, Philadelphia.
26. Tan Y.M., Wong W.K. A comparison of two surgical strategies for the emergency treatment of gallstone ileus. Singapore Medical Journal. 2004;45:69–72. [PubMed]
27. Date R.S., Thrumurthy S.G., Whiteside S. Gallbladder perforation: case series and systematic review. International Journal of Surgery. 2012;10:63–68. [PubMed]

Articles from International Journal of Surgery Case Reports are provided here courtesy of Elsevier