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Logo of jcinvestThe Journal of Clinical Investigation
J Clin Invest. 1977 December; 60(6): 1442–1444.
PMCID: PMC372503

Increased frequency of the MZ phenotype of alpha-1-protease inhibitor in juvenile chronic polyarthritis.


Pi phenotypes of alpha-1-protease inhibitor were determined by isoelectric focusing and print immunofixation in 96 English children suffering from juvenile chronic polyarthritis. A significantly increased frequency of the MZ phenotype (10.41%) was found in comparison with a geographically matched control population (1.6%). The results of this study suggest that the possession of a Z-deficient allele of alpha-1-protease inhibitor could be a predisposing, aggravating, or perpetuating factor in the articular damage occurring in juvenile chronic polyarthritis.

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Selected References

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  • Beard HK, Faulk WP, Conochie LB, Glynn LE. Some immunological aspects of collagen. Prog Allergy. 1977;22:45–106. [PubMed]
  • Bauer EA, Eisen AZ, Jeffrey JJ. Studies on purified rheumatoid synovial collagenase in vitro and in vivo. J Clin Invest. 1971 Oct;50(10):2056–2064. [PMC free article] [PubMed]
  • Ohlsson K, Olsson I. Neutral proteases of human granulocytes. IV. Interaction between human granulocyte collagenase and plasma protease inhibitors. J Lab Clin Med. 1977 Feb;89(2):269–277. [PubMed]
  • Ohlsson K, Olsson I. Neutral proteases of human granulocytes. III. Interaction between human granulocyte elastase and plasma protease inhibitors. Scand J Clin Lab Invest. 1974 Dec;34(4):349–355. [PubMed]
  • Fagerhol MK, Gedde-Dahl T., Jr Genetics of the Pi serum types. Family studies of the inherited variants of serum alpha-1-antitrypsin. Hum Hered. 1969;19(4):354–359. [PubMed]
  • Eriksson S. Studies in alpha 1-antitrypsin deficiency. Acta Med Scand Suppl. 1965;432:1–85. [PubMed]
  • Feldmann G, Bignon J, Chahinian P. The liver in alpha 1-antitrypsin deficiency. Digestion. 1974;10(2):162–174. [PubMed]
  • Cox DW, Huber O. Rheumatoid arthritis and alpha-1-antitrypsin. Lancet. 1976 Jun 5;1(7971):1216–1217. [PubMed]
  • Arnaud P, Wilson GB, Koistinen J, Fudenberg HH. Immunofixation after electrofocusing: improved method for specific detection of serum proteins with determination of isoelectric points. I. Immunofixation print technique for detection of alpha-1-protease inhibitor. J Immunol Methods. 1977;16(3):221–231. [PubMed]
  • Cook PJ. The genetics of alpha1-antitrypsin: a family study in England and Scotland. Ann Hum Genet. 1975 Jan;38(3):275–287. [PubMed]
  • Janoff A. At least three human neutrophil lysosomal proteases are capable of degrading joint connective tissues. Ann N Y Acad Sci. 1975 Jun 13;256:402–408. [PubMed]
  • Shtacher G, Maayan R, Feinstein G. Proteinase inhibitors in human synovial fluid. Biochim Biophys Acta. 1973 Mar 23;303(1):138–147. [PubMed]
  • Ehrlich MG, Mankin HJ, Jones H, Wright R, Crispen C, Vigliani G. Collagenase and collagenase inhibitors in osteoarthritic and normal cartilage. J Clin Invest. 1977 Feb;59(2):226–233. [PMC free article] [PubMed]
  • Ohlsson K. Alpha1-antitrypsin and alpha2-macroglobulin. Interactions with human neutrophil collagenase and elastase. Ann N Y Acad Sci. 1975 Jun 13;256:409–419. [PubMed]
  • Fagerhol MK. Quantitative studies on the inherited variants of serum alpha-1-antitrypsin. Scand J Clin Lab Invest. 1969 Feb;23(1):97–103. [PubMed]

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