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Logo of nihpaAbout Author manuscriptsSubmit a manuscriptHHS Public Access; Author Manuscript; Accepted for publication in peer reviewed journal;
 
From:
J Neurochem. Author manuscript; available in PMC 2013 July 9.
Published in final edited form as:
J Neurochem. 2012 May; 121(3): 475–485.
Published online 2012 March 20. doi: 10.1111/j.1471-4159.2012.07690.x

Figure 4

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Restoration of cysteine at amino acids 6 and 11 in the context of SODMD mutations increases the aggregation propensity

(A) Immunoblots of detergent-extracted HEK293FT cells expressing the indicated SOD1 proteins for 48 hours. (B) Quantification of the aggregation propensity. All values are normalized to the aggregation propensity of A4V (set to 1). Student t-tests were performed to compare aggregation propensities of SOD1 proteins to WT SOD1: *p ≤ 0.05, #p ≤ 0.005. The graphed data represent quantification of at least 3 measurements of distinct immunoblots similar to the image in panel A.

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