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Ann Gen Hosp Psychiatry. 2004; 3: 3.
Published online Feb 13, 2004. doi:  10.1186/1475-2832-3-3
PMCID: PMC368443
Gender difference in QTc prolongation of people with mental disorders
Hiroto Ito,corresponding author1 Toshiaki Kono,2 Shigenobu Ishida,3 and Hisao Maeda3
1National Institute of Public Health, 2-3-6 Minami, Wako, Saitama 351-0197, Japan
2Department of Psychiatry, Division of Neuroscience, Graduate School of Medicine, The University of Tokyo, Japan
3Department of Neuropsychiatry, Kurume University School of Medicine, Japan
corresponding authorCorresponding author.
Hiroto Ito: ito/at/niph.go.jp; Toshiaki Kono: tkono-tky/at/umin.ac.jp; Shigenobu Ishida: ishidas/at/med.kurume-u.ac.jp; Hisao Maeda: maehisa/at/med.kurume-u.ac.jp
Received June 20, 2003; Accepted February 13, 2004.
Abstract
Background
We examined gender difference in QTc interval distribution and its related factors in people with mental disorders.
Methods
We retrospectively reviewed medical charts of patients discharged from a university psychiatric unit between November 1997 and December 2000. Subjects were 328 patients (145 males and 183 females) taking psychotropics at their admission. We examined patient characteristics, medical history, diagnosis, and medication before admission.
Results
Mean QTc interval was 0.408 (SD = 0.036). QTc intervals in females were significantly longer than those in males. QTc of females without comorbidity was significantly longer than that of males.
Conclusion
The influence of gender difference on QTc prolongation in people with mental disorders merits further research.
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