Search tips
Search criteria 


Logo of aghpsycbiomed central web sitesearch.manuscript submission.see also annals of general psychiatry journal in pmc.registration.reference to the article.journal front page.
Ann Gen Hosp Psychiatry. 2004; 3: 3.
Published online 2004 February 13. doi:  10.1186/1475-2832-3-3
PMCID: PMC368443

Gender difference in QTc prolongation of people with mental disorders



We examined gender difference in QTc interval distribution and its related factors in people with mental disorders.


We retrospectively reviewed medical charts of patients discharged from a university psychiatric unit between November 1997 and December 2000. Subjects were 328 patients (145 males and 183 females) taking psychotropics at their admission. We examined patient characteristics, medical history, diagnosis, and medication before admission.


Mean QTc interval was 0.408 (SD = 0.036). QTc intervals in females were significantly longer than those in males. QTc of females without comorbidity was significantly longer than that of males.


The influence of gender difference on QTc prolongation in people with mental disorders merits further research.

Articles from Annals of General Hospital Psychiatry are provided here courtesy of BioMed Central