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Logo of nihpaAbout Author manuscriptsSubmit a manuscriptNIH Public Access; Author Manuscript; Accepted for publication in peer reviewed journal;
 
Int J Psychiatry Med. Author manuscript; available in PMC May 31, 2013.
Published in final edited form as:
Int J Psychiatry Med. 2012; 43(2): 129–151.
PMCID: PMC3668561
NIHMSID: NIHMS463015
Brief Psychotherapy for Depression: A Systematic Review and Meta-Analysis
Jason A. Nieuwsma, PhD,1,2 Ranak B. Trivedi, PhD,3,4 Jennifer McDuffie, PhD,1,2 Ian Kronish, MD,5 Dinesh Benjamin, MD,1,2 and John W. Williams, Jr., MD1,2
1Duke University Medical Center
2Durham VA Medical Center and MIRECC
3University of Washington
4Seattle VA Medical Center
5Columbia University Medical Center
Jason A. Nieuwsma, Ph.D., VA Mid-Atlantic MIRECC, Legacy Towers 800B, 411 West Chapel Hill St., Durham, NC 27701, (919)428-3551 (phone), (919)416-8048 (fax), jason.nieuwsma/at/duke.edu
Objective
Because evidence-based psychotherapies of 12 to 20 sessions can be perceived as too lengthy and time intensive for the treatment of depression in primary care, a number of studies have examined abbreviated psychotherapy protocols. The purpose of this study was to conduct a systematic review and meta-analysis to determine the efficacy of brief psychotherapy (i.e., ≤ 8 sessions) for depression.
Methods
We used combined literature searches in PubMed, EMBASE, PsycINFO, and an Internet-accessible database of clinical trials of psychotherapy to conduct two systematic searches: one for existing systematic reviews and another for randomized controlled trials (RCTs). Included studies examined evidence-based psychotherapy(s) of 8 or fewer sessions, focused on adults with depression, contained an acceptable control condition, were published in English, and used validated measures of depressive symptoms.
Results
We retained 2 systematic reviews and 15 RCTs evaluating cognitive behavioral therapy, problem-solving therapy, and mindfulness-based cognitive therapy. The systematic reviews found brief psychotherapies to be more efficacious than control, with effect sizes ranging from −0.33 to −0.25. Our meta-analysis found six to eight sessions of cognitive behavioral therapy to be more efficacious than control (ES −0.42, 95% CI −0.74 to −0.10, I2=56%). A sensitivity analysis controlled for statistical heterogeneity but showed smaller treatment effects (ES −0.24, 95% CI −0.42 to −0.06, I2=0%).
Conclusions
Depression can be efficaciously treated with six to eight sessions of psychotherapy, particularly cognitive behavioral therapy and problem-solving therapy. Access to non-pharmacologic treatments for depression could be improved by training health care providers to deliver brief psychotherapies.
Index Words: depression, psychotherapy, primary health care, meta-analysis, review, systematic, psychotherapy, brief
Depressive disorders present a major public health concern. The prevalence of current depression among U.S. adults is 6.6% [1], with a lifetime prevalence rate of 16 to 18% [2]. Particularly high rates have been found in primary care settings [3] where a high proportion of patients with depressive disorders are treated [4]. Medication is by far the most commonly utilized intervention in primary care settings [5, 6], despite extensive evidence and clinical guidelines suggesting that efficacious treatments for depression include both pharmacotherapy and psychotherapy [7].
In recent years, there has been a growing interest in and commitment to the integration of psychotherapy and other mental health services into primary care settings [8]. Providing primary care patients with the option of receiving psychotherapy for depression is an important objective for multiple reasons: there are many patients who prefer psychotherapy to medication [9]; there is a need to provide alternative treatments for patients who do not improve on or cannot tolerate antidepressant medication [10]; and there may be unique benefits from psychotherapy in terms of costs and relapse prevention [11].
Perhaps the most significant barrier to providing psychotherapies in primary care settings is that many empirically supported psychotherapy treatment protocols consist of at least 12 to 20 weekly 1-hour sessions [12, 13]. While this treatment duration is much abbreviated compared with older approaches to the provision of psychotherapy [14], it is arguably still too intensive for reliable implementation in primary care settings [15].
Recognizing that time and resource constraints present important barriers to effectively implementing standard-duration psychotherapies (i.e., 12 to 20 sessions) for depression in primary care settings, this review evaluates whether psychotherapy for depression can be efficacious after a period of 8 or fewer sessions. Eight sessions is roughly half the length of standard-duration psychotherapies, and this treatment duration has been used in previous research examining standard-duration vs. brief psychotherapy [16]. The present review aimed to evaluate the evidence on brief psychotherapy for depression by employing a complex systematic review methodology [17], with particular attention devoted to the training received by providers delivering brief psychotherapies and the reporting of clinical outcomes beyond depression severity.
We utilized a combined approach for conducting a complex systematic review [17], identifying and evaluating existing systematic reviews and supplementing these reviews by searching for and evaluating original research not included in these reviews.
SEARCH STRATEGY
We developed search strategies in consultation with a master librarian and conducted searches in three stages. First, we searched MEDLINE (via PubMed), Embase, and PsycINFO for relevant, good-quality, English-language systematic reviews that were published within the past 10 years (January 1, 2000 – May 2010). Second, we used a well-documented Internet-accessible database of psychotherapy trials that was current through January 2010 [18]. We used this database of 243 trials as a data source for original research, searching for studies coded as including adults with a mood disorder who received face-to-face psychotherapy at a dose of eight or fewer therapy sessions. Finally, we searched for publications in MEDLINE (via PubMed), PsycINFO, and Embase from January 2009 (one year prior to the search date of the online database) through August 1, 2010 to complement the Internet-accessible database of psychotherapy trials. We supplemented electronic searching by examining the bibliographies of included studies and review articles. The full search strategies are available upon request from the authors.
STUDY SELECTION
Using prespecified inclusion/exclusion criteria, pairs of trained researchers (either PhD or MD) reviewed the list of titles and abstracts, then selected articles identified from any of the computerized and manual searches described above for further review of the full text. Each article retrieved was reviewed using a brief screening form. To be included in our study, systematic reviews had to be rated as good-quality using quality criteria adapted from a previous review [19], and original research studies had to be an RCT, compare an eligible psychotherapy of eight or fewer sessions to control, and report effects on depressive symptoms. Detailed eligibility criteria are described in Table 1.
Table 1
Table 1
Summary of Inclusion and Exclusion Criteria
DATA EXTRACTION AND QUALITY ASSESSMENT
For systematic reviews, we assessed the comprehensiveness of the search strategy, the description and appropriateness of inclusion criteria, whether primary studies were assessed for quality and the adequacy of the quality measure, the reproducibility of methods to assess studies, whether the results of relevant studies were combined appropriately, whether heterogeneity and publication bias were assessed, and whether the conclusions were supported by the data presented. Systematic reviews were rated “good” if the conclusions were supported by the data presented and there were no important study limitations.
For newly identified original research studies, trained researchers abstracted data in duplicate from published reports into evidence tables. For eligible trials previously included in the two systematic reviews, we abstracted summary data from the reviews and supplemented these data by using the original publications when the reviews had incomplete information. We assessed risk of bias using the key quality criteria described in the Agency for Healthcare Research and Quality (AHRQ) Methods Guide for Effectiveness and Comparative Effectiveness Reviews [20], adapted for this specific topic. We abstracted data on adequacy of randomization and allocation concealment, comparability of groups at baseline, blinding, completeness of followup and differential loss to followup, whether incomplete data were addressed appropriately, validity of outcome measures, and conflict of interest. Using these data elements, we assigned a summary quality score of “good,” “fair,” or “poor” to individual RCTs.
DATA SYNTHESIS AND ANALYSIS
When good-quality systematic reviews were identified, we summarized the reviews’ findings in narrative form. For original research studies, we critically analyzed their characteristics, methods, and findings, and then used published guidelines to evaluate whether the new evidence was likely to change estimates from prior reviews [20]. If so, we updated prior meta-analyses.
Because studies did not use a single common instrument to measure depression severity, our meta-analysis calculated effect sizes for each study by subtracting (at posttest) the average score of the control group from the average score of the experimental group and dividing the result by the pooled standard deviations (SDs) of the experimental and control groups. We then converted these estimates to the number needed to treat (NNT) using the approach described by Kraemer [21]. When studies used more than one validated instrument to assess depression severity, we used the mean of the effect sizes so that each study (or control group) contributed only one effect size. When means and SDs were not reported, we used other statistics (e.g., event rates) to calculate the effect size. For studies with more than one active eligible psychotherapeutic intervention (e.g., behavioral therapy and cognitive therapy arms) compared to a single control, we combined the intervention arms to avoid lack of independence that would be created if we entered each intervention into the analysis separately [22].
We assessed for heterogeneity in outcomes between studies using the Q statistic and the I2 statistic [23]. Publication bias was tested by inspecting the funnel plot of the meta-analysis. We conducted preplanned subgroup analyses by study quality and type of control group; there was not sufficient variability or numbers of studies to conduct other subgroup analyses. We used an influence analysis, which drops one study at a time and recomputes the treatment effect, to determine the influence of individual studies on the overall effect. We used the computer program Comprehensive Meta-analysis, Version 2.2.021 (www.meta-analysis.com/pages/about_us.html), to conduct all meta-analyses. Finally, we assigned strength of evidence ratings for the different brief psychotherapies using principles from the Grades of Recommendation, Assessment, Development, and Evaluation (GRADE) Working Group [24].
SEARCH RESULTS
Systematic Reviews
Using the combined literature search of PubMed, Embase, and PsycINFO, we identified references for 560 potential systematic reviews (Figure 1). Two eligible reviews were retained: Cuijpers and colleagues [25] and Cape and colleagues [26]. Neither review focused exclusively on brief psychotherapy for depression. Cuijpers completed a good-quality meta-analysis of 15 studies that examined psychotherapies for depression in primary care; a sub-analysis was completed on the studies of psychotherapies with 6 or fewer sessions (k=7). Cape completed a good-quality meta-analysis and meta-regression of 34 studies examining the effectiveness of psychotherapies for various mental health problems that consisted of fewer than 10 sessions; sub-analyses were completed on the studies of cognitive behavioral therapy (CBT; k=4), problem-solving therapy (PST; k=5), and counseling (k=4) specifically for depression.
Figure 1
Figure 1
Results of literature search for systematic reviews
Primary Literature
Using the combined searches for primary literature in electronic databases (MEDLINE, Embase, and PsycINFO), in a well-documented Internet-accessible database of psychotherapy trials [18], and in bibliographies of included studies, we identified 866 citations (Figure 2). We retained 20 articles representing 15 unique studies. Only 8 of these 15 studies had been previously reviewed in either the Cuijpers [25] or Cape [26] reviews. Study characteristics from the 15 relevant RCTs of brief psychotherapy are summarized in Table 2. For quality assessments, studies rated as fair or poor were often rated as such due to inadequately addressing incomplete outcome data and not having outcome assessors who were blind to treatment assignment. Characteristics of psychotherapy interventions used in the 15 RCTs of brief psychotherapy are summarized in Table 3. Data were infrequently reported on quality of life, social functioning, occupational status, patient satisfaction, and adverse treatment effects (Table 4).
Figure 2
Figure 2
Results of literature search for RCTs
Table 2
Table 2
Summary of Study Characteristics
Table 3
Table 3
Summary of Intervention Characteristics
Table 4
Table 4
Key Clinical Outcome Measures
EFFICACY OF BRIEF PSYCHOTHERAPY
Systematic Reviews
In the Cuijpers’ systematic review [25], the sub-analysis examining psychotherapies with six or fewer sessions (k=5 PST and 2 CBT) found these treatments to have a small but significant positive effect for the treatment of depression in primary care (ES −0.25, 95% CI −0.48 to −0.02, NNT=7.14). This effect size was not significantly different from that for psychotherapies of 7 to 16 sessions (ES −0.36, 95% CI −0.54 to −0.17). In Cape’s review [26], the sub-analyses on psychotherapies for depression with 10 or fewer sessions demonstrated a significant but small effect favoring brief CBT over usual general practitioner care for depression (k=4; ES −0.33, 95% CI −0.60 to −0.06) and positive but statistically nonsignificant effects for PST (k=5; ES −0.26, 95% CI −0.49 to 0.03) and counseling (k=4; ES −0.41, 95% CI −0.84 to 0.03) over usual general practitioner care. No significant differences in efficacy were found between CBT, PST, and counseling.
Primary Literature
While six of the eight identified PST studies were previously included in the systematic reviews, the prior reviews only included two of the six CBT studies that we identified. Because the 4 newly identified studies of CBT contained 535 of the total 713 participants across the 6 CBT studies, we conducted an updated and more adequately powered meta-analysis of brief CBT (6 to 8 sessions) for depression.
In the meta-analysis, we found that participants receiving brief CBT for depression were more likely than participants receiving a control treatment to have reduced symptoms of depression (ES −0.42, 95% CI −0.74 to −0.10), but treatment effects differed significantly across studies (Cochran Q=13.74, p=0.03, I2=56%) (Figure 3). The ES of −0.42 corresponds to an NNT of approximately 4.5. A funnel plot did not suggest significant publication bias, but with only six studies, this method has limited power to detect publication bias. In an influence analysis conducted to examine the moderate level of variability present, the summary estimate ranged from −0.24 to −0.53, with the trial by Wilson [27] having the greatest influence. This trial was the only CBT study to use a waitlist control condition as the comparator. Based on a priori hypotheses of variables that might influence the effect size estimate, we conducted two sensitivity analyses. In the first, we removed the single poor-quality study [28] and found that brief CBT for depression continued to be significantly more effective than control (ES −0.50, 95% CI −0.91 to −0.09), but treatment effects remained significantly heterogeneous (Cochran Q=13.71, p=0.008, I2=71%). In the second, we removed the poor-quality [28] study and the study with a waitlist comparator [27] and found that treatment effects of brief CBT for depression were smaller (ES −0.24, 95% CI −0.42 to −0.06) but homogeneous (Cochran Q=1.44, p=0.70, I2=0%). This effect size corresponds to an NNT of approximately 8.
Figure 3
Figure 3
Meta-analysis of Brief CBT for Depression
Since only 92 of the total 973 participants across the 8 PST studies were from the 2 newly identified studies of PST, we did not conduct an updated meta-analysis for PST. The single study of MBCT identified in our review found 8 sessions of MBCT to be more efficacious than treatment as usual at reducing depressive symptoms at 8 weeks (F=13.42, p=0.001) [29].
NON-MENTAL HEALTH TREATMENT PROVIDERS
In all four trials that involved non-mental health professionals (e.g., nurses, allied health professionals, and general practitioners) as treatment providers, the intervention was PST. Compared to the PST trials that used solely mental health professionals, the trials involving non-mental health professionals did not have a pattern of results suggesting any meaningful differences in efficacy for PST. Quantitative syntheses to examine differences on the basis of provider type, treatment intensity, individual versus group, or telephone versus in-person could not be completed because there was not an adequate number of studies in each of these subgroups.
We identified 2 systematic reviews and 15 randomized controlled trials of brief psychotherapy (i.e., ≤ 8 sessions) for depression, encompassing 1716 patients with MDD or depressive symptomatology. Both systematic reviews concluded that brief CBT and PST are efficacious for the acute-phase treatment of depression in primary care. This conclusion was corroborated by our analyses of 15 randomized controlled trials, 7 of which had not been included in either of the two identified systematic reviews. Effect sizes for brief psychotherapy are modest but at present appear comparable to those observed in trials of antidepressant medications and of standard duration psychotherapies [30]. Table 5 summarizes the strength of evidence.
Table 5
Table 5
Summary of the Strength of Evidence
Our review found that brief psychotherapies have been provided by psychologists, graduate students, nurses, general practitioners, and other allied health professionals who had received training and supervision specific to the intervention being conducted. Details about training were sparse, meaning that the degree of training necessary to replicate studies’ results is uncertain. A key component of replicating positive treatment effects may be fidelity monitoring, which is likely to be particularly important with generalist clinicians.
This review aimed to determine the overall efficacy of brief psychotherapies rather than the comparative effectiveness of brief vs. standard-duration psychotherapies. However, Cuijpers’ review [25] found no statistically significant differences between psychotherapies delivered in 6 sessions compared to psychotherapies delivered in 7 to 16 sessions. Additionally, in an important trial conducted by Shapiro and colleagues [16], 117 patients with depression were randomized to either 8 or 16 sessions of manualized psychotherapy, and 16 sessions was found to be superior to 8 only for those with severe depression. This trial did not meet our inclusion criteria due to the comparator condition being an active psychotherapy, but the findings are consistent with those from the present review and the trial design merits imitation by other researchers.
The present study has a number of strengths, including a protocol-driven review, a comprehensive search, careful quality assessment, and rigorous quantitative synthesis methods. Additionally, this is the first review to our knowledge to focus exclusively on brief psychotherapy for depression. However, the existing literature leaves multiple unresolved questions. First, the question of whether brief psychotherapies are less efficacious than standard-duration psychotherapies (i.e., 12 to 20 sessions) needs to be more fully answered in the context of controlled trials. Second, too few studies assessed long-term outcomes after the conclusion of brief psychotherapies (e.g., 6 months or longer) or included a broad set of outcome measures (e.g., quality of life, social functioning, and occupational status). Third, it remains to be determined which brief psychotherapies (CBT, PST, or other) can be provided with high treatment fidelity by different professionals, such as nurses, nurse practitioners, primary care physicians, social workers, or clinical chaplains. Fourth, the studies included in this review were composed primarily of Caucasian, middle-aged females, limiting applicability to many other segments of society. Finally, the relatively few studies included in this review did not allow for stratified comparisons on important variables such as depression severity (i.e., mild, moderate, severe), treatment setting (e.g., mental health clinic, primary care), or augmentation of brief psychotherapy with medication.
CONCLUSIONS
Brief psychotherapy is an effective option for the acute-phase treatment of depression. With many protocols requiring only 6 sessions of 30 minutes each that can be provided by either mental health professionals or trained non-mental health providers, brief psychotherapies present an attractive treatment alternative for implementation in the primary care environment. Although future research is plainly needed, immediate attention is demanded by the enormous human suffering and high economic burden associated with depressive disorders.
Acknowledgments
We would like to thank the VHA Office of Quality Performance, the project staff at the Durham VA Evidence-based Practice Center, the peer reviewers of the original VA evidence synthesis report, the VA Mid-Atlantic MIRECC, and the VA Health Services Research and Development Evidence Synthesis Program. The Department of Veterans Affairs Evidence-based Synthesis Program funded this review. The views and opinions in this manuscript are those of the authors and do not reflect those of the VA.
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