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Mol Cell Biol. 1985 February; 5(2): 422–426.
PMCID: PMC366728

Human c-fms proto-oncogene: comparative analysis with an abnormal allele.


The organization of the human c-fms proto-oncogene has been determined and compared with an abnormal allele. The human v-fms homologous genetic sequences are dispersed discontinuously and colinearly with the viral oncogene over a DNA region of ca. 32 kilobase pairs. The abnormal c-fms locus contains a small deletion in its 3' portion. DNA sequencing analysis indicated that it was 426 base pairs in size and located in close proximity to a putative c-fms exon.

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