Search tips
Search criteria 


Logo of molcellbPermissionsJournals.ASM.orgJournalMCB ArticleJournal InfoAuthorsReviewers
Mol Cell Biol. Aug 1988; 8(8): 3546–3549.
PMCID: PMC363593
Induction of neuronal differentiation in PC12 cells by B-cell stimulatory factor 2/interleukin 6.
T Satoh, S Nakamura, T Taga, T Matsuda, T Hirano, T Kishimoto, and Y Kaziro
Institute of Medical Science, University of Tokyo, Japan.
B-cell stimulatory factor 2 (BSF-2) is a lymphokine which induces the final maturation of B cells. BSF-2 acts on a variety of cells other than B cells, and moreover, expression of BSF-2 mRNA is detected in interleukin-1 beta-stimulated glioblastoma and astrocytoma cell lines. Here, we studied the function of BSF-2 on pheochromocytoma PC12 cells, a model system for induction of neuronal differentiation. PC12 cells possess specific receptors for BSF-2. The BSF-2-stimulated PC12 cells expressed the c-fos proto-oncogene transiently, and they began to change morphologically to neurite-extending cells after several days. The number of voltage-dependent Na+ channels was also increased.
Full text
Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (1.0M), or click on a page image below to browse page by page.
Images in this article
Click on the image to see a larger version.
Articles from Molecular and Cellular Biology are provided here courtesy of
American Society for Microbiology (ASM)