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Mol Cell Biol. Apr 1988; 8(4): 1853–1856.
PMCID: PMC363354
Developmentally regulated expression of a human "finger"-containing gene encoded by the 5' half of the ret transforming gene.
M Takahashi, Y Inaguma, H Hiai, and F Hirose
Laboratory of Experimental Pathology, Aichi Cancer Center Research Institute, Nagoya, Japan.
We isolated and sequenced a cDNA clone of the human gene encoded by the 5' half of the ret transforming gene. The nucleotide sequence indicates that it encodes a protein with "finger" structures which represent putative metal- and nucleic acid-binding domains. Transcription of this gene was detected at high levels in a variety of human and rodent tumor cell lines, mouse testis, and embryos. In addition, a unique transcript was observed in testis RNA. When the expression of the unique transcript was examined at different stages of spermatogenesis, a striking increase in mRNA levels accompanied progression from meiotic prophase pachytene spermatocytes to postmeiotic round spermatids. This finger-containing gene may thus function in male germ cell development.
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