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Eye (Lond). 2013 April; 27(4): 567–568.
Published online 2013 January 18. doi:  10.1038/eye.2012.299
PMCID: PMC3626003

Conjunctival granulomatosis in a patient with ulcerative colitis


Inflammatory bowel disease can be associated with a variety of ophthalmic complications. Here we present a case of conjunctival granulomatosis in a patient with ulcerative colitis (UC).

Case report

A 32-year-old male presented with bilateral conjunctival granulomata. He had no past ophthalmic history and was in good health. The granulomata were restricted to the palpebral conjunctiva and fornices (Figure 1). They were excised but recurred within 3 months. Over the next ten years, he had multiple excisions of recurrent granulomata from the upper and lower palpebral conjunctiva of both eyes.

Figure 1
Bilateral conjunctival granulomata.

Histological examination consistently reported a severely inflamed granulation tissue with a mixed acute and chronic inflammatory cell infiltrate. Topical steroids reduced the rate of recurrence of the granulomata. Systemic investigations including allergy testing revealed no systemic associations.

At the age of 42, he presented with a 6-week history of bloody diarrhoea and weight loss. UC was diagnosed on colonoscopy and biopsies that showed crypt architectural distortion, patchy cryptitis and increased inflammatory cells in the lamina propria. Granulomata were not seen in the biopsy specimen. The colitis settled with a course of intravenous and oral steroids and his bowel disease has remained in remission since. During this period his conjunctival disease remained inactive. Fourteen months later he developed a new granuloma in the lateral canthal conjunctiva of the left eye (Figure 2). He was restarted on topical prednisolone and the lesion was excised.

Figure 2
A recurrent conjunctival granuloma in the left lateral canthus.


Inflammatory bowel disease includes UC and Crohn's disease and is characterised by chronic inflammation of the intestines. Both UC and Crohn's have been associated with ophthalmic complications, the most common of which are uveitis, episcleritis, scleritis and keratitis.1, 2, 3 Conjunctival granulomata can form in response to a foreign body, allergen, infectious organism or as part of a systemic disease process, which include sarcoidosis, Wegener's granulomatosis and Churg-Strauss.

There are only two reports of conjunctival granulomatosis in IBD, both in patients with Crohn's disease and not UC.4, 5 In one case the lesions were similar in appearance to this case but in the other bilateral conjunctival circumlimbal nodules are described, neither had a prolonged course. In our case, the ophthalmic findings started 10 years before any bowel symptoms and it is possible that they are unrelated. However, extensive investigations failed to identify any other cause and it is worth noting that during treatment for his UC the eyes were quiescent. It is also interesting to note that although granulomata are classically found in Crohn's disease, they occasionally occur in UC.6 This would suggest that it is plausible that the conjunctival granulomata seen in this case are due to the same underlying disease process that caused the UC. Our case is the first in the literature to describe conjunctival granulomatosis in a patient with UC.


The authors declare no conflict of interest.


This work has not been presented at any meetings.


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