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Logo of nihpaAbout Author manuscriptsSubmit a manuscriptHHS Public Access; Author Manuscript; Accepted for publication in peer reviewed journal;
 
JAMA Dermatol. Author manuscript; available in PMC 2014 February 1.
Published in final edited form as:
PMCID: PMC3624889
NIHMSID: NIHMS423010

The Association of Pediatric Psoriasis Severity with Excess and Central Adiposity: An International Cross-sectional Study

Abstract

Objective

Investigate the relationship of excess and central adiposity with pediatric psoriasis severity.

Design, Setting and Participants

Multi-center, cross-sectional study of 409 psoriatic children. Psoriasis was classified as mild (worst Physician’s Global Assessment (PGA) <3 with body surface area (BSA) <10%) or severe (worst PGA >3 with BSA >10%). Children were enrolled from 9 countries July 2009-December 2011.

Main Outcome Measures

Excess adiposity (body mass index (BMI) percentile) and central adiposity (waist circumference (WC) percentile and waist-to-height ratio).

Results

Excess adiposity (BMI >85th percentile) occurred in 37.8% (n=155) of psoriatics vs. 20.5% (n=42) of controls, but did not differ by severity. The odds of obesity (BMI >95th percentile) overall in psoriatics vs. controls were OR=4.29, 95% CI=1.96-9.39, but were higher with severe (OR=4.92, CI=2.20-10.99) than mild (OR=3.60, CI=1.56-8.30) psoriasis, particularly in the U.S. (OR=7.60, CI=2.47-23.34, and OR=4.72, CI=1.43-15.56, respectively). WC >90th percentile occurred in 9.3% (n=19) of controls, 14.0% (n=27) of mild, and 21.2% (n=43) of severe psoriatics internationally, and especially in the U.S. (12.0% of controls, 20.8% of mild, and 31.1% of severe psoriatics). Waist-to-height ratio was significantly higher in psoriatic (0.48) vs. control (0.46) children, but unaffected by psoriasis severity. Children with severe psoriasis at their worst, but mild at enrollment, showed no difference in excess or central adiposity from children who remained severe at enrollment.

Conclusion

Globally, children with psoriasis have both excess adiposity and increased central adiposity, regardless of severity. The increased metabolic risks associated with excess and central adiposity warrant early monitoring and lifestyle modification.

Keywords: adipose tissue, adiposity, adolescent, body mass index, child, metabolic syndrome, obesity, psoriasis, waist circumference, weight

Psoriasis is an immune-mediated inflammatory skin disease that affects 2.5-3.2% of the population.1,2 Twenty-two to 33% of psoriasis begins during childhood, especially during adolescence2-5, and the incidence in children has more than doubled since the early 1970’s.3 Adults with psoriasis have an increased risk of obesity, myocardial infarction, stroke, and diabetes.6-9 Recent studies also suggest the association of psoriasis and obesity in children. Of 211 North American children with moderate-to-severe psoriasis in an etanercept trial, 37% were obese (body mass index (BMI) >95th percentile).10 Among 96 Italian children with mild to severe psoriasis, 48% were overweight (BMI >85th percentile) vs. 27% of controls.11 Using a German pediatric registry, obesity (by ICD-10 code) occurred 1.7-fold more often in psoriatic children than controls.5 In a U.S.-based registry, overweight, moderately obese, and extremely obese children had 1.31-, 1.39-, and 1.78-fold greater odds, respectively, of having psoriasis (by ICD-9 code) than children with normal weight.12 These investigations provide evidence that children with psoriasis are at increased risk of being overweight or obese. However, ascertainment bias and under-identification are limitations of registry studies, which rely on ICD codes for diagnosis of psoriasis and obesity, rather than direct examination and measurements to calculate BMI. In addition, the risk of excess adiposity relative to psoriasis severity has received little attention. Increased waist circumference (WC) percentile13-16 and waist-to-height ratio (WHtR)15-20 are non-invasive surrogates for central adiposity and more sensitive indicators for metabolic disease than BMI percentile, including in children15, 16, 19, 20. WC percentile is increased in adults with psoriasis21, but has never been assessed in psoriatic children. WHtR has more recently been found to be a better predictor of cardiovascular risk than BMI or WC percentiles17, 19, but has never been assessed in adult or pediatric patients with psoriasis.

Using an international cohort of children with psoriasis, we have further examined the relationship between adiposity and psoriasis in children. Our goals were specifically to: a) evaluate the impact of disease severity on the association of psoriasis with excess adiposity (being overweight or obese); b) assess whether central obesity, as a surrogate for higher cardiovascular risk, was related to psoriasis severity; and c) examine if the association of excess adiposity with psoriasis varied regionally. We hypothesized that both excess adiposity and central adiposity are most highly correlated with psoriasis of greater severity, but that children with mild psoriasis are also at risk. Furthermore, we expected that psoriatic children in the United States would have a greater risk of excess and central adiposity than children from other countries.

METHODS

Study design and population

A multi-center, international, cross-sectional study was performed to determine the relationship between adiposity and psoriasis severity in children. Subjects were recruited between June, 2009 and December, 2011 from all psoriasis patients who presented to 18 dermatology referral centers with known psoriasis expertise in the Americas (Brazil, Canada, Chile, United States), Europe (Italy, Netherlands, Turkey, United Kingdom), and Asia (Malaysia). Inclusion criteria included age 5-17 years and a >6 month history of plaque psoriasis. Diagnosis was confirmed by a psoriasis specialist. Siblings were excluded in both the psoriatic and control populations. Children of similar age and sex (but not matched for ethnicity) without skin or systemic inflammatory disease (e.g. with nevi, molluscum contagiosum, warts, acne) and without a family history of psoriasis or psoriatic arthritis were also recruited in the United States, Netherlands, Italy, and Malaysia. To minimize ascertainment bias, an attempt was made to recruit all patients serially at presentation, and no potential subject refused. Parents and subjects, as required by each center’s Institutional Review Board or Ethics Committee, provided written informed consent. Investigators completed a questionnaire with each patient/parent that addressed patient history, race/ethnicity, severity of psoriasis at its worst, and history of psoriasis/psoriatic arthritis and metabolic disease in family members. A projected sample of 169/group provided 80% power to detect rates of excess adiposity from 22% among controls to 37% among psoriatics.10 Subjects who indicated race as “Other” (2 control, 3 MP and 4 SP) were excluded from analysis of impact of race due to their racial heterogeneity. Tanner stage was not examined, but a secondary analysis was performed on subsets of children ages 5 through 7 and 15 through 17 years as representative of prepubertal and postpubertal subjects based on established puberty ranges.22 De-identified data was compiled centrally by the International Psoriasis Council, and statistical analysis was performed at Northwestern University, Chicago.

Anthropometric measures

Weight and height were measured and BMI was calculated by dividing subject weight (in kg) by height2 (in m2). An age- and sex-adjusted BMI percentile was assigned using the modified LMS estimation procedure from 2000 Center for Disease Control (CDC) growth charts23 Excess adiposity was defined as being either overweight or obese. Subjects with BMI >85th and <95th percentile were classified as overweight, and those with BMI > 95th percentile as obese.24, 25 BMI percentile <5 was considered underweight, and 5-<85 healthy weight. WC was measured midway between the most inferior rib and the superior border of the iliac crest with an inelastic measuring tape. WC percentile was determined according to sex, age, and ethnicity-specific cutoffs.26 WC was classified into six percentile groups with the two highest being the 75th-90th and >90th percentiles. WHtR was considered as a continuous measure of risk, but for estimating odds of excess central adiposity defined by WHtR, cut-offs established by Kahn et al. were used to define high (≥0.539) and intermediate (≥0.490) levels of cardiovascular risk.19

Determination of psoriasis severity

Psoriasis severity was classified as mild or severe was based primarily on Physician Global Assessment (PGA)27 and secondarily on Body Surface Area (BSA). PGA was scored as 0 (none) to 5 (severe). To establish severity within the pediatric population, PGA of 4-5 was designated as severe psoriasis (SP), and PGA of 1-2 mild psoriasis (MP). A “moderate” score of PGA 3 was designated MP if the BSA was <10% and SP if the BSA was >10%.28 Peak severity historically was used to classify patients as mild vs. severe, and severity was also determined at enrollment. For all psoriatics, a current or previous history of treatment with phototherapy and/or systemic medications was recorded. The same physician scored both worst and current severity of subjects at each site to minimize the risk of per subject or per center inter-observer variability.

Statistical analysis

Descriptive statistics are presented as counts and percentages for categorical variables, mean and standard deviations for continuous data, and medians and interquartile range for psoriatic duration. Analyses include generalized linear mixed models for binary (logit link function), categorical (generalized logit link function) and ordinal (gamma link function) outcome data, respectively, and mixed models for outcomes which were normally distributed. All models included a random effect of study center and were adjusted for age, sex, continent or race.

Models comparing MP to SP were also adjusted for systemic medication, phototherapy, and disease duration. Correlation between PGA and BSA severity scales was assessed using a Spearman’s rank correlation, as the two measures are not on the same scale. Agreement between BMI categories and WC categories was assessed using a weighted kappa. Interactions between psoriatic groups and age, race (or continent), and sex were assessed to gauge evidence of effect modification; interaction terms were also fit to examine the possibility of a differential effect of race on adiposity levels. When the interaction of race and psoriasis was significant, further analyses were stratified to determine the effect of race within psoriatic groups and vice versa. A priori there was interest in comparing psoriatics versus controls and MP versus SP; hence, a significance level of 0.05 was used for all comparisons. While this does increase the chance of a type I error, many comparisons were done to assess if the relationships observed in the primary analyses were seen in subgroups, not to draw specific conclusions about subgroups. All analyses were run in SASv9.2, Cary, NC.

RESULTS

Children with Psoriasis Internationally Have Excess Adiposity, Regardless of Severity

Of 614 subjects enrolled from nine countries, 203 (33.0%) had MP and 206 (33.6%) had SP based on assessment of peak severity; 205 (33.4%) were age- and sex-comparable non-inflammatory controls (Table 1). Age and sex distribution was similar among regions, although ethnicity varied, reflecting different populations regionally. The classification based on PGA severity correlated well with severity based on BSA (rs=0.763, p=0.001). Severity classification was further validated by use of phototherapy and/or systemic immunosuppressant medications in 56.5% of children internationally and 65.3% of U.S. subjects with SP (vs. 21.8% and 16.8% with MP, respectively) (Tables 1 and and2).2). Having a history of diabetes, hypertension, hyperlipidemia, obesity, psoriasis or psoriatic arthritis in immediate family members was not significantly different in SP vs. MP children. Categories of adiposity defined by BMI and WC percentiles moderately agreed (weighted kappa (κw)=0.55 (95% CI, 0.50-0.61)). The mean age of children with psoriasis was 12.2 years, with no significant difference between MP and SP groups (Table 1). A significantly higher percentage of children with psoriasis than controls showed excess adiposity (37.8% vs. 20.5%) or obesity (20.2% vs. 7.3%) (p<0.001). The odds ratio for excess adiposity in psoriatic children of all severities vs. controls was 2.65 (CI=1.70-4.15) and for obesity was 4.29 (CI=1.96-9.39); similarly in the U.S. the odds ratio for excess adiposity was 4.02 (2.11-7.63) and for obesity was 6.61 (2.16-20.17) (Table 3). There was no modification by age (p=0.914), pubertal status (p=0.583), or age group (p=0.968). Disease duration did not correlate with excess adiposity (Spearman correlation coefficient 0.008).

Table 1
Demographic and Characteristics of All Subjects by Severity
Table 2
Demographic and Characteristics of U.S. Subjects by Severity
Table 3
Age, Sex, Race/Continent, and Center Adjusted Odds Ratios

The Odds Ratio of Obesity (vs. Overweight) is Highest in Severe Psoriasis Internationally

More SP than MP children were obese (7.3% of controls, 16.8% of MP, and 23.7% of SP, p<0.001) (Table 1); the OR for obesity (vs. healthy weight) was 4.92 (CI-2.20-10.99) for SP and 3.60 (CI-1.56-8.30) for MP (Table 3). In the U.S., obesity was seen in 8.3% of controls and 19.2% of MP children, but occurred in 34.0% of SP children (p=0.013); the OR for being obese (vs. healthy weight) was 4.72 (CI=1.43-15.56) for MP, but 7.60 (CI=2.47-23.34) for SP (Tables 2 and and3).3). Among children with excess adiposity, SP had the highest odds of obesity (OR=2.85 (CI=1.26-6.42) internationally, whereas the odds of obesity was not increased for MP compared to controls (Table 3).

Children with Severe, but not Mild, Psoriasis Have Greater Central Adiposity

Internationally, the odds of a WC percentile >90 was significantly greater for children with psoriasis overall vs. controls (OR=2.52, CI=1.24-5.12) and SP vs. controls (OR=3.06, CI=1.53-6.15), but not MP vs. controls (OR=1.90, CI=0.90-4.01) (Tables 1 and and3).3). In the U.S. the odds ratio of having a WC percentile >75th or >90th was significantly increased in psoriasis overall vs. controls (OR=1.77, CI=1.03-3.07 and OR=3.47, CI=1.39-8.66, respectively) and SP children vs. controls (OR=2.05, CI=1.12-3.76 and OR=3.85, CI=1.64-9.00, respectively), but not MP children vs. controls (Tables 2 and and3).3). WHtRs were significantly higher in children with psoriasis vs. controls internationally (p=0.002) and in the U.S. (p=0.010) (Tables 1 and and2).2). In parallel with WC percentiles, the odds of a WHtR ≥0.539 was significantly higher for children with psoriasis overall vs. controls (OR=3.10, CI=1.39-6.90) and SP vs. controls (OR=4.10, CI=1.80-9.31), but not MP vs. controls (OR=2.21, CI=0.92-5.32) (Table 3). In the U.S., the odds ratio of having at least a WHtR above the normal range (>.490) was also increased in psoriasis overall (OR=1.77, CI=1.02-3.09) and in SP children (OR=2.06, CI=1.12-3.81), but not in MP children (OR=1.45, CI= 0.75-2.79) (Table 3). Disease duration did not affect central adiposity (Spearman correlation coefficients of −0.008 and −0.010 for WC category and WHtR, respectively).

Among Children Internationally, the Greatest Association of Excess Adiposity and Central Adiposity with Psoriasis is Seen in U.S. Children

The difference in excess adiposity rates between psoriatics and controls was greatest in the Americas vs. other continents (p<0.001, Table 4; Figure 1) and in U.S. vs. non-U.S. sites (p=0.002, Table 5). In addition, differences in central adiposity were greater in the Americas vs other continents (WC%, p = .002; WHtR, p=0.016; Table 4) and in U.S. vs. non-U.S. psoriatics (WC%, p=0.015; WHtR, p=0.048; Table 5). The excess adiposity in psoriatics versus controls was similar across U.S. racial groups (Table 4). However, significantly greater rates for excess adiposity were seen in U.S. Hispanics/African-Americans (59.5%), in comparison with Whites (44.5%) and Asians (40.0%) (p=0.026), and both WC percentiles and WHtRs were higher in African-Americans/Hispanics and Asians than in Whites (p=0.001 and p=0.021, respectively; Table 4).

Figure 1
Box-Plots of BMI percentiles, defined using CDC growth charts, by psoriasis disease severity and continent of study participants. Diamonds within box plots represent group means and horizontals lines medians. Boxes represent interquartile range and whiskers ...
Table 4
Comparison of Demographic and Metabolic Features by Continent (International) and Race (U.S.)a
Table 5
U.S./non-U.S. Comparison of Demographic and Metabolic Characteristics

Clinical Improvement Does not Lower the Odds of Obesity

No difference was noted for SP children who transitioned to MP vs. SP children who remained SP in the odds of having excess adiposity (OR= 1.34 (CI=0.70-2.59)), obesity (OR=0.67 (CI=0.31-1.43)), or central adiposity (OR=0.88 (CI=0.45-1.72)). Internationally, 136 (65.7%) children with SP had transitioned to MP by enrollment, of whom 60% used phototherapy and/or systemic medications (19.2% phototherapy alone, 20.0% systemic immunosuppressants, and 20.0% both). Sex (p=0.702), age (p=0.280), duration (p=0.279), systemic medication use (p=0.480), or continent (p=0.337) did not predict those who transitioned. By enrollment, 67 (65%) U.S. children with SP had transitioned to MP. Sex (p=0.543), age (p=0.081), duration (p=0.129), systemic medication use (p=0.286), or phototherapy (p=0.118) similarly did not correlate with transition, although Whites were more likely to improve than non-Whites (78.7% vs. 45.2%, p=0.001) and transition was more likely among younger patients (OR=0.82 (CI=0.070-0.97), p=0.019).

DISCUSSION

The prevalence of childhood obesity has increased dramatically worldwide29-32, although a recent study shows stabilization. Being overweight or obese during childhood is associated with an increased risk of sleep apnea33, cardiovascular risk factors34, insulin resistance, orthopedic complications35, 36, and mortality as an adult from cardiovascular disease.37 Our large, cross-sectional study overcomes the limitations of registry data and further supports the association of pediatric psoriasis with increased BMI percentile. Importantly, children with psoriasis internationally, regardless of severity, have significantly greater odds than controls of being overweight or obese, and thus are at increased risk of complications related to excess adiposity. Most MP children with excess adiposity were overweight, but not obese, while most SP children with excess adiposity were obese. Consistently, while the odds of obesity were increased in children with MP (OR=3.60), the odds of obesity were much higher for children with SP (OR=4.92), particularly in the U.S. (OR=6.61). These odds ratios are considerably greater than those for adults in the U.K. with SP (OR=1.79) and MP (OR=1.27)8, and for metabolic syndrome in U.S. adults with psoriasis of all severities (OR=1.96)38, suggesting a greater association of obesity and psoriasis with childhood-onset vs. adult-onset psoriasis. The particularly high odds of obesity in U.S. children with psoriasis suggest that environment habits (higher caloric diet and less exercise) may impact the risk.

BMI percentile remains the standard method for identifying overweight and obese pediatric patients39, but WC and particularly WHtR are surrogates for central/visceral adiposity that are considered better indicators than BMI of metabolic risk.13, 14, 17, 18, 40 Pediatric studies have found WC >90th percentile and, even more so, high WHtRs to correlate better than BMI percentile with a higher risk of hypertension, hypertriglyceridemia, low high density lipoproteins, and fasting insulin levels.15, 16, 19, 41-45 Our data demonstrate that children with SP (but not MP) have higher odds than controls of having a high WC percentile and WHtR, and thus have additional risks associated with central adiposity.

As a non-blinded cross-sectional study, ascertainment and selection biases are inherent risks. Given that all pediatric psoriasis patients were solicited and agreed to participate, ascertainment bias was limited in MP and SP groups; because measures of disease severity (PGA and BSA) were assessed per standard procedure and by the same physician, disease severity was also measured without bias. Although selection bias for non-inflammatory controls is possible, all eligible children without inflammatory disease were asked to participate; as seen in Figure 2, the distribution of percentiles is approximately uniform, as would be expected in a completely random sample. To establish growth standards for children older than 5 years of age, both the CDC and the World Health Organization (WHO) used to the 1977 National Center for Health Statistics data. The CDC standards were selected for this study because they were the more conservative measure and were more likely to identify subjects who were actually overweight and obese.46 International growth standards, including distribution for WC and WHtR, should be developed.

Figure 2
Histograms of BMI percentiles based on age- and sex-specific CDC growth charts by study groups in the US and International cohorts.

BMI percentile distributions showed increased adiposity in both MP and SP American and European subjects, but only in MP children from Asia. While the reason for the lower mean BMI percentile of Asian SP children is currently under investigation, a recent study demonstrated higher proportions of both obese and underweight children in the Chinese population.47 It is possible that the differences in diet and exercise between the American/European countries and Malaysia as well as genetic variations could also account for regional variations in adiposity. Nevertheless, the small sample size, relatively small Asian control group, and large percentage of underweight SP Asian children (24%) limit our data interpretation. The “ethnicity-adjusted” cutoffs for WC percentile were based on >9,000 U.S. children of African, Mexican, or European, but not Asian descent26, which could explain the difference in WC percentile distribution in control Asian children vs. other ethnic groups. Indeed, central adiposity varies by ethnic origin among the Malay population48, and our questionnaire did not distinguish among ethnic subtypes or socio-economic status, both of which can impact the genetic and environmental factors that affect adiposity.

The underlying basis for the relationship between excess adiposity and psoriasis is not well understood. However, overproduction of Th1 and Th17 inflammatory cytokines is associated with both obesity49 and psoriasis50 in adults, suggesting that chronic inflammation drives both disorders. Indeed, remission of severe psoriasis has been described in adults after substantial weight loss as a result of gastric bypass surgery.51, 52 Treatment of psoriatic adults with both cyclosporine and a 24-week weight loss diet (which reduced BMI and waist size) led to a greater reduction in severity than cyclosporine alone53, further suggesting a relationship between psoriasis and obesity.

Despite the clear association of psoriasis with obesity, an unanswered question is whether high BMI is the precursor of psoriasis in children or whether psoriasis leads to an increased BMI percentile through chronic cytokine release from psoriatic tissue, compounded by a lifestyle that may favor excess adiposity (less physical activity, increased risk of depression).54, 55 A recent prospective cohort study of 892 affected adult women found that increased adiposity preceded the occurrence of new onset psoriasis21; we are currently addressing if increased adiposity precedes psoriasis onset in children.

In our study, SP children who had transitioned to MP at enrollment showed no difference in adiposity from SP children who remained severe, despite controlling for other factors. While not longitudinal, these data suggest that effective intervention for psoriasis may not alter the tendency towards adiposity. A possible confounder for this conclusion is the reported association of use of TNF-α inhibitors and increases in BMI in adults with psoriasis, hypothesized to result primarily from suppression of TNF-α-induced myocyte catabolism.16, 20, 56, 57 Although the numbers of SP children administered TNF-α inhibitors (etanercept, adalimumab and/or infliximab) by enrollment (23/82 using systemic medications globally and 17/51 in the U.S.) were insufficient for statistical comparison, 52% of SP children globally (59% in the U.S.) administered TNF-α inhibitors remained overweight or obese vs. 41% of SP children globally (52% in the U.S.) administered other systemic immunosuppressants. The possibility that use of TNF-α inhibitors in children leads to weight gain, despite the ameliorative effects on inflammation, deserves further investigation.

In conclusion, children with psoriasis internationally, regardless of severity, are more likely to be overweight or obese and thus at increased risk of complications related to excess adiposity. The association of central adiposity is greatest in children with severe psoriasis, and monitoring of these patients should be especially vigilant. Should future studies show excess adiposity to be a precursor for psoriasis, attempts at early weight loss and lifestyle modification will be important, not only to decrease the risk of metabolic disease, but also to modulate the course of pediatric psoriasis.

Acknowledgements

We are indebted to the following dermatologists who were principal investigators at their centers and enrolled children in this investigation: Dr. Ricardo Romiti (Brazil), Dr. Ian Landells (Canada), Dr. Claudia de la Cruz (Chile), Professors Serap Utas and Osman Kose (Turkey), Dr. Ruth Murphy (U.K.),and Drs. April Armstrong, Leah Belazarian, Neil Korman, Craig Leonardi, Moise Levy, Fu-Tong Liu, and Karen Wiss (U.S.) We acknowledge the tremendous contribution of Christy Langan at IPC for collecting de-identified data and providing it for data analysis. We appreciate the assistance of Drs. Latanya Benjamin, Candrice Heath, Sapna Patel Vaghani, Shields Callahan, and Sinae Vogel in enrolling subjects, Drs. Anthony Mancini and Sarah Chamlin for referring patients, Dr. Dennis West for his daily supervision of research, and Dr. Alfred Rademaker for his early statistical assessment of data. Finally, we are grateful to the clinical trials unit staff at the centers worldwide at which patients were enrolled.

Funding/Support: This study was supported by a grant from the International Psoriasis Council (IPC)(www.psoriasiscouncil.org), which participated in study design and served as the repository of de-identified information. IPC had no role in the analysis and interpretation of the data, preparation, review, or approval of the manuscript. Medical writers were not used.

Footnotes

Author Attributions: Drs. Paller, Mercy, and Kwasny had full access to all of the data in the study. Dr. Paller takes responsibility for the integrity of the data and the accuracy of the data analysis.

Study concept and design: Dr. Paller.

Acquisition of data: Drs. Paller, Seyger, Choon, Cordoro, Girolomini, Menter, Tom, Mahoney and Oostveen.

Analysis and interpretation of data: Drs. Paller, Mercy, and Seyger

Drafting of the article: Drs. Paller, Mercy, and Kwasny.

Critical revision of the manuscript for important intellectual content: Drs. Seyger, Choon, Cordoro, Girolomini, Menter, Tom, Mahoney and Oostveen.

Statistical analysis: Dr. Kwasny.

Obtained funding: Dr. Paller.

Administrative, technical, or material support: Dr. Paller

Study supervision: Drs. Paller and Mahoney.

Financial Disclosure: During the past 5 years, Dr. Paller served as an investigator without personal compensation for Amgen-Immunex, Astellas and Leo Pharma, and as a consultant with honorarium for Abbott, Amgen-Immunex, Johnson and Johnson, and Leo Pharma. Dr. Seyger received grants from Leo Pharma and Pfizer, served as a consultant for Pfizer and Abbott, gave lectures for Pfizer and travelled with Abbott, Pfizer and Leo Pharma to meetings; fees were paid directly to the institution. Dr. Choon received honoraria for service on the scientific advisory boards for Janssen-Cilag and Pfizer, and as a speaker for Janssen-Cilag and Leo Pharma. Dr. Girolomoni has received honoraria from lectures, manuscript preparation, development of educational programs and/or board membership from Abbott, Celgene, Centocor, Janssen, Merck-Serono, Pfizer, Merck Sharp & Dohme and Novartis. Dr. Menter has received honoraria as a consultant for Abbott, Amgen, Centocor, Eli Lilly, Steifel and Wyeth, as a speaker for Abbott, Amgen, Centocor, Galderma and Wyeth, and for providing testimony for Galderma. Dr.Tom’s salary related to inflammatory skin disease research is in part supported by a Career Development Award, K23AR060274, from NIH/NIAMS. Dr. Mercy’s salary in part is supported by a fellowship by the National Psoriasis Foundation. Drs. Kwasny, Cordoro, and Oostveen declared no potential conflicts of interest.

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