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Conceived and designed the experiments: JL SX. Performed the experiments: SX. Analyzed the data: SX. Contributed reagents/materials/analysis tools: JL SX. Wrote the paper: SX JL.
In modeling individuals vaccination decision making, existing studies have typically used the payoff-based (e.g., game-theoretical) approaches that evaluate the risks and benefits of vaccination. In reality, whether an individual takes vaccine or not is also influenced by the decisions of others, i.e., due to the impact of social influence. In this regard, we present a dual-perspective view on individuals decision making that incorporates both the cost analysis of vaccination and the impact of social influence. In doing so, we consider a group of individuals making their vaccination decisions by both minimizing the associated costs and evaluating the decisions of others. We apply social impact theory (SIT) to characterize the impact of social influence with respect to individuals interaction relationships. By doing so, we propose a novel modeling framework that integrates an extended SIT-based characterization of social influence with a game-theoretical analysis of cost minimization. We consider the scenario of voluntary vaccination against an influenza-like disease through a series of simulations. We investigate the steady state of individuals’ decision making, and thus, assess the impact of social influence by evaluating the coverage of vaccination for infectious diseases control. Our simulation results suggest that individuals high conformity to social influence will increase the vaccination coverage if the cost of vaccination is low, and conversely, will decrease it if the cost is high. Interestingly, if individuals are social followers, the resulting vaccination coverage would converge to a certain level, depending on individuals’ initial level of vaccination willingness rather than the associated costs. We conclude that social influence will have an impact on the control of an infectious disease as they can affect the vaccination coverage. In this respect, our work can provide a means for modeling the impact of social influence as well as for estimating the effectiveness of a voluntary vaccination program.
In the control of infectious diseases by voluntary vaccination, individuals decisions on whether or not taking the vaccine will affect the vaccination coverage and, hence, the effectiveness of disease control , , since the prevention of disease transmission requires the vaccination coverage of a host population to be above the level of herd immunity threshold .
Existing studies on individuals vaccination decision making have typically focused on several determinants associated with the risks and benefits of vaccination, including the perceived risk of disease infection –, the perceived safety and efficacy of vaccine ,  (e.g., vaccine side-effect rate and the related adverse complications), as well as the social financial costs associated with vaccination and disease infection  (e.g., charge of vaccine administration, expenses for infection treatment, and absence from work).
Besides these factors, individuals vaccination decisions are also subjected to the impact of social influence in that an individuals behaviors or opinions are affected by those of others . For example, the social influence on individuals vaccination decisions can come from the interactions among them, such as recommendations given by friends or family members , , suggestions from health professionals , and advices given by trusted colleagues . The effects of social influence on human health related behaviors have long been observed. In the case of 2003 SARS outbreak in China, individuals avoidance behaviors arose as a response to the circulation of short messages about disease outbreaks . As for vaccination, health related newscasts would change individuals perceptions of vaccine safety and efficacy . The attitudes shared among parents would influence the vaccination decisions of their children . In this regard, modeling vaccination decision making should be treated as not merely a process of payoff optimization, but also a process of individuals response to the impact of social influence.
In order to better understand individuals vaccination decision making, in this study, we take a dual-perspective view to address both the cost analysis of vaccination decisions and the impact of social influence. As illustrated in Figure 1, we consider a group of individuals that make their vaccination decisions by both minimizing the associated costs and evaluating the decisions of others (i.e., social influence). Specifically, we consider that the social settings of individuals are structured with reference to their interaction relationships (i.e., connected individuals and their social closeness). Therefore, the impact of social influence among them will be heterogeneous with respect to the structure of their interactions. In addition, when individuals interact with those having similar choices, their decisions may be further affirmed; otherwise, their decisions may be weakened . In such a case, social impact theory (SIT) provides a computational approach to characterizing the impact of social influence with respect to individuals interaction relationships . Generally speaking, SIT describes how individuals change their attitudes/decisions in a structured social environment, and further suggests that the strength of the social impact be determined by the characteristics of the source (e.g., various attitudes/decisions), the closeness of their social relationships, and the number of sources holding similar attitudes/decisions . In our current work, we propose a novel modeling framework for describing individuals vaccination decision making by integrating an extended SIT-based characterization of social influence with a game-theoretical analysis of cost minimization. In this model, we use a conformity rate to describe the impact of social influence on vaccination decision making, in terms of individuals tendency of being affected by the social influence of others. Additionally, we represent individuals interaction relationships with reference to a social network structure, in which individuals are heterogeneously connected with different numbers of connected neighbors and the social closeness of their interactions. We parameterize the proposed model with an influenza-like disease as well as a real-world social network.
By carrying out a series of simulations on voluntary vaccination, we examine the steady state of individuals decision making and evaluate the vaccination dynamics as well as the effect of disease control, in terms of vaccination coverage and the resulting disease infection rate, respectively. By doing so, we aim to investigate the interplay of cost minimization and social influence on individuals vaccination decision making, and examine the impacts of different levels of individuals conformity towards the impact of social influence. Furthermore, we provide a new modeling framework that incorporates the impact of social influence for investigating the effectiveness of voluntary vaccination for infectious diseases control.
We consider a voluntary vaccination program for controlling an influenza-like infectious disease (e.g., seasonal flu), in which individuals need to decide whether or not to be vaccinated each season based on their perceived risk of disease infection. It is assumed that individuals will have some knowledge about the vaccine and the disease (e.g., acquired from their previous experience and/or from public media and health authorities), and about others vaccination decisions through their social interactions. For such a situation, we construct a computational model that describes how an individual arrives at his/her vaccination decision with respect to the cost analysis of vaccination decisions, and the social influence of others decisions. Based on the constructed model, we aim to investigate the impact of social influence on individuals vaccination decisions as well as on the disease control.
We take a dual-perspective view on modeling individuals vaccination decision making that incorporates individuals evaluation of vaccination associated costs as well as the impact of social influence. In doing so, we introduce an individual-based model, as described in Figure 2. In the figure, denotes an individual s vaccination decision. There are two possible decisions that an individual can make: corresponds to an acceptance of vaccination, and represents a rejection. We utilize a social network to characterize the structure of individuals interactions, in which the nodes correspond to individuals and te edges denote the interaction relationships among them. Each edge has a weight , which represents the closeness of interactions between individuals and .
Individuals can evaluate the costs associated with their decisions and then arrive at their optimal choices by minimizing the costs. Meanwhile, individuals may also convert their decisions due to the impact of social influence (i.e., neighbors vaccination decisions). Thus, individuals vaccination decision making will be modeled here to include two aspects: (1) cost minimization and (2) the impact of social influence. The parameters used for modeling individuals vaccination decision making are summarized in Table 1.
There are two types of costs associated with an individuals vaccination decision: (1) the cost of vaccination (e.g., the potential risk of vaccine side-effects or the expense of vaccine administration) and (2) the cost of disease infection if not vaccinated (e.g., disease complications, expenses for treatment, or absence from work). We let and denote the costs associated with vaccination and disease infection, respectively, and use represent the perceived risk of disease infection for individual . Then, we can introduce a cost function for individual with a decision , as follows:
where denotes the cost associated with accepting vaccination, and denotes the cost associated with rejecting vaccination.
Next, without loss of generality, we let describe the relative ratio of and . Thus, we can further transform the cost function in Eq. 1 into the following:
Here, we assume that individuals can estimate the risk of disease infection based on their perceived disease severity, as reflected in the perceived disease transmission rate, , as well as their neighbors vaccination decisions, as represented by and for the numbers of neighbors with the decisions of vaccination or not, respectively. In addition, vaccinated individuals are assumed to be successfully immunized from disease infection and unvaccinated individuals will be possibly infected and thus transmit disease. Therefore, the perceived infection risk, , can be computed corresponding to the proportion of unvaccinated neighbors as follows:
Based on the above formulation, an individual can arrive at an optimal choice by minimizing the cost function in Eq. 2. In our proposed model, individual will accept vaccination (i.e., ) if , reject vaccination (i.e., ) if , and keep his/her decision unchanged in the previous step if . We can write this cost-minimized choice of individual , , in the following form:
If all individuals follow the same strategy of minimizing their cost functions, after some iterations of decision making, they will reach a steady state, in which all individuals will have no incentive to change their decisions in the next step.
In addition to the above-mentioned cost minimization, an individual may affect by those decisions of others, i.e., due to the impact of social influence , and then convert the cost-based choice to the social opinion of his/her neighbors. According to social impact theory (SIT) , , the strength of such a social influence will be subjected to the structure of individuals interactions, e.g., the types of opinions (i.e., acceptance or rejection ), interaction relationships (i.e., social closeness ), and the number of opinion sources (i.e., the numbers of vaccinated and unvaccinated neighbors, and , respectively). In our social network, for individual , the strengths of social influence for two opposite opinions (i.e., vaccination acceptance and rejection), described by and , can be accordingly computed based on  as follows:
We use to denote the formalized social opinion resulting from the social influence of individual s neighbors. As a modification of the standard SIT definition (where corresponds to the opinion with the larger strength of social influence), being either acceptance or rejection of vaccination will be determined by comparing the influences of two opposite opinions. We let denote the discrepancy between and . Then, we normalize as follows:
Here, we use to denote the probability that social opinion is to accept vaccination, and to reject vaccination. Therefore, we can write in the following form:
where is computed from the Fermi function as follows:
The Fermi function is a sigmoid function that has been widely used for describing individuals behavioral changes as a response to the payoff discrepancy of two different choices , . Here, describes individuals responsiveness to the impact discrepancy of two opposite opinions. As shown in Figure 3, a larger value of means the choice with a higher social influence will be more inclined to dominate the social opinion even the discrepancy of the two opposite social influence, , is relatively small.
Next, we introduce a probability, , called individuals conformity rate, that indicates the degree of individuals tendency towards adopting the social opinion of his/her connected neighbors, that corresponds to how likely individual will convert his/her cost-minimized choice () to the social influence formalized opinion (). Thus, corresponds to the case of a cost-based decision maker, whereas indicates that the individual is an absolute social follower (i.e., ignoring his/her own cost evaluation). In other words, the final decision of individual can be expressed as follows:
In order to evaluate the impact of individuals vaccination decision making on disease control, we further construct a disease model to describe the threshold of vaccine coverage for mitigating an epidemic (i.e., the reproduction number is less than one). The parameters used for estimating the vaccination threshold are listed in Table 2.
For the sake of illustration, we use a standard SIR model to describe an influenza-like disease transmission in a group of individuals that are densely aggregated (e.g., students in a school), which can be treated as a homo-mixed population for disease transmission. Individuals are divided into three compartments with respect to their epidemiological states, i.e., susceptible (S), infectious (I), and recovered (R). In addition, the number of individuals in each compartment is denoted by , , and . When the natural birth and death of the population are not taken into account, the overall population size is calculated as . The disease spread dynamics is described by the following set of differential equations:
where is the risk of disease infection for susceptible individuals that is proportional to the percentage of infectious population size. denotes the disease transmission rate that is the probability of disease transmission between the mixing of infectious and susceptible individuals. describes the recovery rate that corresponds to the time period for an infected individual to be naturally recovered and thus immunized from secondary infection.
Reproduction number (i.e., the number of secondary infections caused by a typical infectious individual in a completely susceptible population , ) indicates a threshold for disease transmission; that is, if , disease transmission will naturally decay. In such a compartmental disease transmission model, is given as follows , :
Therefore, the vaccination threshold for mitigating an epidemic is estimated as the reproduction number less than one (i.e., ). The corresponding vaccination coverage, denoted by , can be estimated as follows:
For our simulations, we calibrate the parameters of individuals vaccination decision making based on the scenario of the 2009 H1N1 influenza epidemic, in which reproduction number was estimated as and recovery rate was set to 0.312 (i.e., a 3.2-day recovery period for disease infection) –. In order to focus our studies on the impact of social influence, we assume that the perceived disease transmission rate is equal to that of the actual disease transmission, i.e., . In addition, we construct a social network based on the data of individuals close proximity interactions (i.e., distance less than 3 m) at an American high school , where the social closeness between individuals and corresponds to the frequency of their interactions (i.e., the sum of all interactions between the two individuals during the day). The total number of nodes is and the average node degree (i.e., the number of connected neighbors) is 35. The average edge weight (i.e., social closeness) is 115 units. Based on our model parameterization, we carry out Monte Carlo simulations to experimentally study individuals vaccination decision making and the impacts of the resulting vaccination coverage on disease control.
Based on the proposed decision model, we have conducted a series of simulations on vaccination dynamics to estimate the vaccination coverage at the steady state of individuals decision making. As shown in Figure 4, we first investigate the interplay of cost minimization and the impacts of social influence on individuals vaccination decision making with reference to three initial levels of individuals vaccination willingness: , , and . Generally speaking, the level of vaccine uptake will be subjected to the cost ratio and individuals initial level of vaccination willingness, when individuals conformity rate takes different values. Specifically, the simulation results in Figures 4A, 4B, and 4C show that when the impact of social influence is relative weak (i.e., conformity rate is relatively small), the cost of vaccination (i.e., cost ratio ) fundamentally determines the resulting vaccination coverage in that increasing the cost of vaccination will lower individuals vaccination willingness (i.e., the steady state of individuals decision making). In our considered scenario, the vaccination coverage is around when cost ratio . Gradually, if is decreased and approaches , the vaccination coverage will become as high as . Based on our model design, when an individual perceives that all of his/her connected neighbors have decided for vaccination, the individual will keep his/her previous choice of non-vaccination even if the cost of vaccination is zero, due to the consideration that disease transmission will no longer exist.
Furthermore, we can observe that the strength of social influence (i.e., conformity rate ) can adjust the aforementioned impacts of cost ratio on individuals vaccination decisions. As in the extreme case that individuals are pure cost-based decision makers (i.e., ), the resulting vaccination coverage will be completely determined by the relative cost of vaccination (i.e., cost ratio ). On the other hand, as in the extreme case that individuals are absolute followers of social opinion (i.e., ), the impact of social influence will promote a universal vaccination coverage, the level of which depends on individuals initial level of willingness instead of the associated costs. In this case of simulation, when , the vaccination coverage at the steady state of decision making will converge to around for individuals vaccination willingness at the initial level of (i.e., as shown in Figure 4A), at the level of (i.e., as shown in Figure 4B), and at the level of (i.e., as shown in Figure 4C).
In addition, the impacts of varying conformity rate (i.e., individuals tendency to adopting social opinions) are also observed as the adjustment of vaccination decisions with reference to different situations of vaccination associated costs (i.e., cost ratio ). When individuals become more likely being affected by social influence (i.e., gradually increasing conformity rate ), as shown in Figure 4A, the impact of social influence tends to increase the vaccination coverage when the cost of vaccination is low (i.e., ). On the other hand, when the cost of vaccination is relatively high (i.e., ), the impact of social influence will reduce the resulting vaccination coverage at the steady state of individuals decision making. Furthermore, when conformity rate approaches , the vaccination coverage will drop/increase sharply and finally converge to a fixed level that depends on individuals initial level of vaccination willingness.
Based on the earlier-mentioned SIR model, we have investigated the impact of social influence on disease control by evaluating disease infection rates (i.e., the percentage of individuals being infected as a result of disease transmissions) with respect to different vaccination coverage resulting from individuals decision making.
Figure 5 shows the disease infection rates with respect to the interplay of individuals cost minimization and the impact of social influence on vaccination decision making (i.e., the values of cost ratio and conformity rate ranging between and , respectively). With respect to our considered epidemic scenario (i.e., basic reproduction number ), the simulation results in Figure 5A, 5B, and 5C show that disease infection can be eliminated given a relatively lower cost of vaccination (i.e., cost ratio ) and a moderate impact of social influence (i.e., conformity rate ).
Specifically, when individuals are less likely to being affected by social influence (i.e., conformity rate ), the effectiveness of disease control is generally determined by the relative cost of vaccination (i.e., cost ratio ) in that a lower vaccination cost can lead to a reduction in the disease infection rate due to a resulting higher vaccination coverage. Furthermore, as individuals tendency of being affected by social influence become strengthened (i.e., conformity rate ), the effect of vaccination cost on disease control will be weakened accordingly, while individuals initial level of vaccination willingness matters. In the extreme case of (i.e., individuals are absolute followers of social influence), the disease infection rate is observed as high as for the initial level of vaccination willingness at , as shown in Figure 5A. If the initial level of vaccination willingness is set as (i.e., as shown in Figure 5B), the disease attack rate will be relatively higher than the situation of the initial level at (i.e., as shown in Figure 5C), where cost ratio and conformity rate .
Besides, we have examined the steady-state vaccination coverage and the resulting disease attack rate with respect to different initial levels of individuals vaccination willingness prior to their decision making, the results of which are shown in Figure 6. We can note that individuals initial level of willingness will affect the converged level of the steady-state vaccination coverage as well as the effectiveness of disease control when individuals are absolute followers of social opinions (i.e., conformity rate ). In our simulations, when the initial level of individuals vaccination willingness is , the converged steady-state vaccination coverage is around (Figure 6A). The vaccination coverage will reach and , if the initial levels of vaccination willingness are and , respectively. In addition, we can observe that there exists a critical phase transition in vaccination coverage when individuals initial level of vaccination willingness is between and (Figure 6A). That is to say, in the situation of individuals being absolute social followers, there is a threshold value in terms of individuals initial level of vaccination willingness that can be used to evaluate the effectiveness of a voluntary vaccination program for eliminating the epidemic (Figure 6B).
In order to investigate the sensitivity of our results, in what follows, we further consider individuals vaccination decision making with respect to the different values of disease reproduction number: (1) ; (2) ; (3) . Figure 7 shows the vaccination thresholds for eliminating the epidemic with respect to different basic reproduction numbers .
Figure 8 shows the vaccination coverage at the steady state of individuals decision making with respect to different disease reproduction numbers. Here, we can observe the similar impacts of social influence in all three considered situations: the impact of social influence will increase the vaccination coverage when the relative cost of vaccination is small (see Figures 8A, 8B, and 8C), decrease it when is relatively large (see Figures 8.g, 8.h, and 8.i), and bring it to a certain level when individuals become followers of social influence (i.e., conformity rate approaches 1). The simulation results further show that when the impact of social influence is relatively weak (i.e., conformity rate ), relatively severe disease transmissions in terms of a larger reproduction number (i.e., ) will increase the vaccination coverage. While, if the impact of social influence is strengthened (i.e., conformity rate approaches 1), the vaccination coverage at the steady state of individuals decision making is mostly determined by individuals initial level of vaccination willingness, rather than the related costs and disease severity.
The phenomena of social influence that individuals behaviors or opinions are affected by their social environment have long been observed and studied, such as in the domains of political voting ,  and consumer purchasing decisions , . In the context of vaccination, social influence can affect individuals vaccination decisions and thus the effectiveness of disease control in terms of the resulting vaccination coverage . In this study, we address the impact of social influence on individuals vaccination decision making, vaccination coverage, and disease control. Towards this end, we have provided a dual-perspective view on modeling individuals vaccination decision making by incorporating the impact of social influence with the game-theoretical analysis of vaccination cost minimization. In a group of individuals, the impact of social influence on an individuals decision making relies on the structure of how he/she interacts with others. In order to characterize the impact of social influence in such an interactive environment, we have used social impact theory (SIT) to characterize the strength of social influence on changing individuals vaccination decisions with respect to their interaction relationships. We have used individuals social network to represent the structure of their interaction relationships. Based on our proposed model, we have examined the impact of social influence on individuals decisions and on the effectiveness of disease control (i.e., vaccination coverage), with respect to three determinants: (1) the relative cost of vaccination decision, i.e., cost ratio ; (2) individuals conformity to social influence, i.e., conformity rate ; and (3) individuals initial level of vaccination willingness.
By parameterizing the proposed model with a real-world contact network and with the epidemiological scenario of 2009 H1N1 influenza, we have carried out a series of simulations on individuals voluntary vaccination. The simulation results have confirmed that the relative cost of vaccination (i.e., cost ratio ) is one of the determining factors in the voluntary vaccination coverage. In our simulations, such results can be observed if individuals are less likely to be affected by social influence (i.e., conformity rate is relatively small). While, if individuals become more susceptible to social influence (i.e., is large), the impact of social influence has been found to increase the vaccination coverage when the cost of vaccination is small and, conversely, reduce the vaccination coverage when the cost is large. In the extreme case where individuals are absolute social followers (i.e., conformity rate ), the vaccination coverage at the steady state would converge to a certain level that merely depends on individuals initial level of vaccination willingness, instead of the vaccination associated costs.
In modeling individuals vaccination decision making, several mathematical models have been earlier proposed that utilize payoff-based approaches to characterizing vaccination decision making with respect to individuals perceived costs and benefits of vaccination –. Bauch et al. ,  characterized individuals vaccination decisions as a modified minority game by exploring the herd immunity effect; that is, in a group of mixed individuals, vaccinating a proportion of them would decrease the infection risk for the rest of individuals . In consideration of that, game theory has been used to describe individuals interactive decision making in favor of optimizing personal payoffs , . Cojocaru  extended the game-theoretical model of vaccination decision making by considering a finite number of heterogeneous population groups. Perisic et al. ,  further incorporated individuals contact networks into the vaccination game analysis. Moreover, some studies have considered social and psychological aspects of decision making (e.g., social learning process  and imitation behaviors , , , ). While, others have considered the issues of incomplete information by adding either the potential discrepancy between individuals perceptions and real situations (e.g., the perceived disease prevalence and the adverse effects of vaccine , ) or different sources of information (e.g., previous disease prevalence or vaccination programs –). Besides the payoff-based analysis, Salathe et al. in  investigated the clustering of vaccinated and unvaccinated individuals with an opinion formation model. They proposed that the probability for an individual changing his/her vaccination opinion is proportional to the ratio of neighbors that have an opposite opinion.
As an improvement over the above-mentioned existing models, we consider an individuals vaccination decision as a hybrid process balancing his/her self-initiated cost minimization (i.e., individuals minority-seeking-like behaviors by exploring the herd immunity effect) as well as the social influence of neighbors decisions (i.e., social conformity behaviors). Our model introduces a parameter (i.e., conformity rate) to modulate individuals tendency towards these two decision making mechanisms: an individual will adopt his/her cost-minimized decision, or convert to the social opinion of his/her connected neighbors. Different from the existing studies that address individuals vaccination decision making as a process of opinion formation (e.g., Salathe et al. in ), here we further take into account the heterogeneities of individuals interaction relationships by exploiting an extended SIT-based characterization of the strength of social influence. Additionally, by incorporating the impact of social influence, we are able to investigate the impact of individuals initial level of vaccination willingness on the vaccination coverage of individuals decision making.
By computationally characterizing the impact of social influence, this study has practical implications for understanding individuals vaccination behaviors and for improving the effectiveness of adopted vaccination policies. In the recent years, the rapidly increasing use of new communication tools e.g., internet-based social media services, has further amplified such a social influence –. For instance, the efficacy or the adverse effects of vaccines would be debated , , and the opinions on either accepting or rejecting vaccination would fast spread among individuals , . We have identified that individuals initial level of vaccination willingness as an important factor in determining the final vaccination coverage due to the impact of social influence (i.e., individuals social conformity). Our results have shown that when conformity rate approaches , the vaccination coverage at the steady state of individuals decision making will be polarized given different initial levels of individuals vaccination willingness. Moreover, the empirical studies that survey the determinants of individuals vaccination decisions in a social environment can readily provide us a practical means for measuring and evaluating individuals conformity to social influence . As has been shown in our study that individuals vaccination decisions can be affected by both the associated costs and their conformity to social influence, it becomes necessary and feasible for public health authorities to estimate the level of individuals acceptance of vaccine prior to the start of a voluntary vaccination program, as well as to timely assess and enhance the effectiveness of their adopted vaccination policies, e.g., providing certain financial subsidies to reduce the cost of vaccination.
So far, our study has provided a general modeling framework for incorporating the impact of social influence into the individuals decision making and disease control. It should be pointed out that the obtained results of this study may be subjected to the considered social network (e.g., students interactions within an American high school). In our proposed model, the social influence accounts only for the localized interactions between an individual with his/her connected neighbors. Additionally, by utilizing the SIT-based characterization of social impact, an implicit assumption is that individuals are passive recipients of social influence and their active behaviors have not been taken into account.
It would be interesting for us to further consider some of the related aspects in our future work:
Public media represents another type of information source that will affect individuals vaccination decision making. Due to broadcasting effect, the transmission of social influence through public media may be faster and wider. Related work by Breban  discussed the effects of media on the fluctuation of vaccination coverage. For the future work, it is possible to extend the current model by incorporating the effects of public media, e.g., by adding a super node that interacts with a large portion of nodes.
To focus on the SIT-based characterization of social influence, we have assumed that individuals are homogeneous in disease infection, e.g., susceptibility, infectivity, and infection risk. In this regard, our modeling framework will be further extended to incorporating individual variations in disease transmission as well as in their social characteristics (e.g., creditability). It would be desirable to further improve our simulations by differentiating physical contacts for infectious disease transmission from interaction relationships for social influence. Along this line, related work by Eames  constructed a parent network for describing vaccination decision and a children network for representing disease transmission, and found that the impact of social influence would be influenced by the overlap of these two networks.
In this work, we have only considered individuals making vaccination decisions based on their perceived infection risk, which may come from either their previous experience of disease and vaccine or the awareness about the upcoming epidemic season. In the real world, real-time disease dynamics could also affect vaccination dynamics, i.e., disease outbreaks may increase individuals willingness for vaccination. In the future, we will extend our model by characterizing the interplays between individuals vaccination decisions and the dynamics of disease spread.
The authors would like to express their gratitude to the three anonymous reviewers who provided constructive comments on further improving this article. They would also thank other members of the AOC Research Group at HKBU for their feedback on this study.
The research work reported in this article has been supported in part by the HIT Strategic Development Fund at HKBU. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.