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Logo of nihpaAbout Author manuscriptsSubmit a manuscriptHHS Public Access; Author Manuscript; Accepted for publication in peer reviewed journal;
Cancer Nurs. Author manuscript; available in PMC 2013 September 1.
Published in final edited form as:
PMCID: PMC3619385

Correlates of Quality of Life among African American and White Cancer Survivors



African Americans continue to suffer disproportionately from cancer morbidity and mortality with emerging evidence suggesting potential quality of life (QOL) disparities in the survivorship period.


To assess sociodemographic, clinical, and psychosocial factors associated with physical and mental health QOL (PHQOL and MHQOL) among African American and white cancer survivors.


Patients were recruited from tumor registries. Telephone interviews were conducted with 248 African American and 244 white respondents with a history of breast, prostate, or colorectal cancers. Multivariate regression models were used to assess what factors were associated with PHQOL and MHQOL.


Key racial differences in adjusted analyses included poorer MHQOL scores among African Americans compared to white survivors. Furthermore, race moderated the relationship between perceived social support and MHQOL, where higher social support levels were associated with increased MHQOL among African Americans. Other correlates of QOL impacted racial groups similarly. For example, factors associated with PHQOL scores included being unemployed, uninsured, the presence of medical comorbidities, a longer time since diagnosis and higher levels of cancer related stress appraisals. Factors associated with MHQOL scores included being unemployed, higher levels of daily stress, higher levels of stress associated with the diagnosis, higher levels of education, higher levels of perceived social support, and higher levels of spirituality.


Interventions aimed at increasing social support may have important implications for improving QOL outcomes among African Americans.

Implications for Practice

Measuring and understanding factors associated with QOL have important implications for patient adjustment and clinical decision-making.


Long-observed gaps in five-year cancer survival rates for members of racial/ethnic minority groups compared to white cancer patients are beginning to narrow.1 Among African Americans the overall five-year survival rate has improved in the past four decades from a low of 27% in the 1960s to current rates of 58%.1 Despite these promising trends, African Americans continue to suffer disproportionately from cancer morbidity and mortality with emerging evidence suggesting potential quality of life (QOL) disparities in the survivorship period.2-4 The same factors that contribute to racial disparities earlier in the cancer care continuum - advanced stage of diagnosis,5 less access to timely treatments and quality of care,6 the presence of medical comorbidities,7 and poor information and decision-making support8 - are also likely to increase the risk for poor survivorship outcomes among African Americans. Beyond the experience of breast cancer patients, relatively few studies have been conducted to examine the effect of cancer diagnosis on the quality of life (QOL) of African American cancer survivors. Additionally, little is known about the demographic (e.g., age), clinical (e.g., cancer type) and psychosocial (e.g., stress and coping) factors that may influence QOL outcomes among this highly underserved subpopulation of cancer survivors.9-11 The purpose of this study was to examine physical and mental health quality of life (QOL) outcomes and the correlates of these outcomes in a sample of African American and white breast, prostate and colorectal cancer survivors. Identifying the mechanisms underlying poor QOL outcomes across diverse patient populations of cancer survivors has important implications for patient adjustment, clinical decision-making, research, and public policy.10,12

Quality of Life

Health related QOL is a multidimensional construct defined as the degree to which one's physical, emotional, social, and spiritual well-being are affected by an illness and its treatment.13 To date, studies examining the influence of race on cancer-related QOL have primarily been conducted with breast cancer patients with mixed results. In a study of African American and white women with a history of breast cancer, no differences in overall QOL were observed after controlling for socioeconomic and other clinical variables.14 Similarly, Rodrigue did not observe any differences in a heterogeneous sample of African American and white cancer survivors in psychological adjustment, mood, or health care satisfaction.15 However, other studies have provided evidence of poorer QOL among African American cancer survivors compared to other groups. For example, Paskett et al reported significantly poorer QOL in physical functioning, general health, and role limitations among African American compared to white breast cancer survivors even after taking into account education level, presence of comorbidities, age at study entry, and life events.16 Similarly, Bowen et al found that African American breast cancer survivors had lower physical health QOL compared to whites while taking into account socioeconomic factors.17 Lowered levels of physical functioning14 and more difficulty in the activities of daily living (an indicator of physical health status)18 have also been reported in African American breast cancer patients compared to their white counterparts. Alternatively, several studies have reported higher levels of emotional well being and mental health among African American breast cancer survivors relative to whites and other ethnic minority women.2,10

In the past decade, research on the QOL of African American males with a history of prostate cancer has emerged. Similar to the literature on race and QOL outcomes among African American women with breast cancer, study findings have been mixed. For example, in a study examining the effects of race on QOL of prostate cancer patients, Halbert et al found that after controlling for sociodemographic, clinical, stress and religious coping factors, African American men reported better emotional well-being compared to white men, although there were no significant racial differences observed in physical functioning.19 In contrast, after controlling for demographic, treatment type and medical comorbidities, African American men with prostate cancer reported significantly lower levels of physical and emotional functioning compared to white men.20-22 The inconsistent findings regarding race and QOL outcomes may be a result of study differences in patient sample characteristics, measurement issues, and disease factors. Additional research is warranted to better understand the relationship between race and QOL outcomes in cancer survivors.

Correlates of Quality of Life Outcomes

Research primarily focused on samples of white cancer patients suggests relationships between demographic, clinical, and psychosocial risk factors and cancer-related QOL. Demographic risk factors for low cancer-related QOL and psychosocial distress include lower socioeconomic status,10,12 being female and single marital status23, and lower levels of formal education.24 Clinical and treatment variables that affect QOL and related adjustments include younger age at diagnosis,25 more advanced stage of illness26, longer time since diagnosis27 and the presence of medical comorbidities at the time of the cancer diagnosis.28 Finally, psychosocial correlates of lower QOL and poorer adjustment include inadequate social support,29 less-adaptive coping responses,30 and lower levels of spirituality.31 Despite the well-known cancer disparities among African Americans, the relationship between the above demographic, clinical and psychosocial risk factors and QOL among African American cancer survivors has been largely unexplored. Exploration of these factors is important because race may interact with some or all of the above risk factors and influence how African Americans adjust to a cancer diagnosis. For example, cancer-related distress is a common experience of cancer patients.32-34 In most instances, elevated rates of emotional distress following a cancer diagnosis resolves over time.35 However, African American and white cancer survivors may differ in the magnitude and type of stressors associated with their cancer diagnosis. Further, there may be cultural factors associated with the availability and use of coping resources. Consequently, African Americans may be more vulnerable to the adverse psychosocial effects of cancer and experience a lower quality of life.

In summary, research examining racial differences in QOL outcomes in the survivorship period has resulted in mixed results. Further, little is known about the survivorship experiences of African Americans with cancer diagnoses other than breast cancer or the factors that may be associated with poorer outcomes. To date, much of the research on QOL outcomes among diverse populations of cancer survivors has been atheoretical. However, previous research suggests that constructs such as clinical, psychological, social, and spiritual well-being are important contributors to QOL13. More recent work by Ashing–Giwa36,37 and others16,17 have described the importance of constructs related to sociodemographic and health care factors on QOL, especially in racial minority and other underserved groups. We use the above definition of quality of life and constructs to guide the variables used in our research models.

Research Questions

This paper addresses a significant gap in the literature by examining the mental and physical health QOL outcomes among African American and white cancer survivors with a history of breast, prostate, and colorectal cancer. Based on previous research, we posit that QOL among cancer survivors is associated with the following clinical and non-clinical factors: demographic characteristics of patients, clinical factors, cancer-related stress, and psychosocial factors. Specific research questions to be addressed were: 1) Do African American and white cancer patients differ on physical and mental health QOL outcomes? and 2) Are observed racial differences in QOL outcomes accounted for by sociodemographic, clinical, and psychosocial (i.e., stress and coping resources) factors.


Sample Design and Data Collection

Data for this paper come from a larger survey study aimed at examining the treatment decision-making and cancer related outcomes of cancer patients.8 The larger study sample included 248 African American and 244 White patients diagnosed with breast, prostate, or colorectal cancer and diagnosed within the past three years. The following sampling approaches were used to obtain a sample of urban and non-urban African American cancer patients in Illinois. First, all 79 Illinois hospitals with a cancer registry and located in the 15 Illinois counties with at least 10 reported African American cancer cases (any site) per year were included in the initial recruitment plan. Additionally, three other hospitals located in bordering states but known to serve Illinois residents were included. Finally, to increase the overall number of non-urban African Americans in the sample, additional non-overlapping cases were identified from the Illinois State Cancer Registry (ISCR). After each African American patient was recruited, a similar white comparison patient was identified in terms of cancer site, gender, age, and time since diagnosis and recruited from the same hospital pool as the African American (see Table 1). This method was used as a recruitment strategy for both the hospitals and ISCR. A total of 753 patients meeting eligibility criteria (African American or white, breast, prostate or colorectal cancer diagnosis, and within three years of an initial diagnosis) were identified through 33 hospital registries and the Illinois State Cancer Registry and forwarded to the Survey Research Laboratory (SRL) at the University of Illinois, who conducted telephone interviews. Upon telephone contact by SRL, 149 cases were found to be ineligible (more than 36 months since diagnosis, other cancer site, deceased, non-English speaking). Of the qualifying cases (N=604), 492 (81.5%) completed the interview (44 were not found, 51 refused to participate and 17 started the interview, but did not complete the majority of the questions and were therefore excluded from the analysis).

Table 1
Comparisons between African American and white Cancer Patients on Hospital and Clinical Characteristicsa

There was no attempt to achieve race concordance between patients and interviewers: however, SRL interviewers are carefully trained and supervised and are experienced in surveying diverse populations. On average interviews lasted between 60 to 90 minutes. Respondents received a $30 gift card for participation. Prior to study implementation, the survey and study protocol were reviewed and approved by The Institutional Review Boards at the University of Chicago and the University of Illinois at Chicago.

Study Measures

Quality of Life

The physical and mental health component summary scales of the Medical Outcomes Study 36-item Short Form Health Survey (SF36) were used to measure QOL outcomes.38 Four subscales make up the physical health QOL summary measure including physical functioning, role limitations due to physical problems, bodily pain, and general health and four subscales make up the mental health QOL summary measure including energy/vitality, social functioning, role limitations due to emotional problems, and mental health. In the current sample, the internal consistency as measured by Cronbach's alpha was 0.84 for the physical health summary scale and 0.81 for the mental health summary scale.

Sociodemographic Factors

Socioeconomic factors included education (<high school, high school/GED, some college, and ≥college degree), income (≤$30,000, $30,000-$50,000, and >$50,000), employment status [employed, unemployed (this category included disabled), or retired], and health insurance status [none, public (Medicare/Medicaid), and private (including military and other)]. Demographic variables included race (African American and white) and gender.

Clinical Factors

Clinical and treatment-related factors measured were: age at diagnosis in years (26-49, 50-64, 65-74, and ≥75), time since diagnosis in months (≤ 12, 13-18, 19-24, and 25-36), cancer site (colorectal, breast, or prostate), currently in treatment (yes/no), and other medical comorbidities (0, 1 or 2). We grouped cancer stage at diagnosis into three categories (early = 1 and 2, late = 3 and 4, and unknown stage of diagnosis). We included a category for unknown due to more than 50% of participants reporting stage as unknown.

Psychosocial Factors

Stress variables included life disruption associated with their illness (1 = not at all disruptive to 10 = extremely disruptive), stress associated with diagnosis (1 = not at all stressful to 10 = extremely stressful), and daily stress due to cancer and other factors (1 = not at all stressful to 10 = extremely stressful). These items were used in a previous study of information seeking among cancer patients.37

Coping resources measured included marital status, perceived support, and spirituality. Marital status was measured as married/with partner or not currently married/widowed. Perceived social support was measured using three items from the Multidimensional Scale of Perceived Social Support39: emotional help and support from family, presence of a special person to help in time of need, and whether or not the family helped with decisions (1 = strongly disagree to 4 = strongly agree). A composite measure of social support was generated by summing these three variables. Responses ranged from 3 to 12, with higher scores indicating higher levels of perceived social support. The internal consistency as measured by Cronbach's alpha was 0.75. A measure of social network size used for coping was created by summing the types of people from whom patients sought help including: other cancer patients, medical providers, clergy, a spouse or partner, family members, and friends (1 = yes, 0 = no, range 0-6). The internal consistency as measured by Cronbach's alpha was 0.71. The Functional Assessment of Chronic Illness Therapy-Spiritual Factors Scale (FACIT-SP)40 was used to measure spirituality (alpha = 0.87 for the current sample).

Data Analysis

African American and white cancer participants were compared on all study variables using X2 tests for categorical variables and two-sample Student's t-tests for continuous variables and scales. Multivariate regression models were used to assess what factors were associated with physical and mental health QOL. As discussed in the methods section, African Americans and a comparison sample of white cancer patients were selected based on 1) geographic area of diagnosis hospital, 2) bed size, 3) hospital has cancer center/program, 4) teaching hospital, 5) type of cancer, 6) age at diagnosis, and 7) time since diagnosis. Despite sampling procedures intended to minimize group differences on these hospital and clinical characteristics, a greater percentage of African American participants were diagnosed in an urban hospital and tended to be younger at diagnosis compared to white participants (Table 1). Therefore, in multivariate regression analyses we adjusted for geographic area of diagnosing hospital and age at diagnosis. Regression models also included cancer type and time since diagnosis since these clinical factors are known to be associated with QOL. Finally, multivariate regressions with interactions terms (e.g. race × spirituality) assessed whether race impacted the relationship between psychosocial factors (stress and coping resources) and the QOL outcomes. Data were analyzed using Stata/SE version 11.


Sample Characteristics

Table 2 describes participants' characteristics, the physical and mental health QOL outcomes, and comparisons by race. African American participants differed from whites on a range of demographic variables including education, income, employment, insurance coverage and marital status. The only medical characteristic that differed between the groups were younger age of diagnosis and the greater likelihood of medical comorbidities among African Americans compared to white patients (Table 2). Measures of stress did not differ based on race. However, compared to white participants, African Americans had lower mean scores for social support but higher mean spirituality scores. Additionally, unadjusted mean scores for both physical and mental health QOL outcomes were lower for African American compared to white participants.

Table 2
Comparisons Between African American and white Cancer Patients in Sociodemographic Factors, Clinical Factors, Psychosocial Factors and QOL Outcomes.

Physical Health QOL

Multivariate regressions examined the relationship between independent variables and physical health QOL. As shown in Table 3, Model 1 explained 35% of the variance in physical health QOL [F(26, 430) = 10.62, p<.001, adjusted R2= 0.354]. Factors that were significantly associated with poorer physical health QOL included being unemployed, uninsured, having one or two comorbidities, having greater life disruptions due to treatment and having higher levels of daily stress. In contrast, a longer time since diagnosis and having greater levels of stress due to the diagnosis were associated with better physical health QOL. After controlling for study covariates, race was not an independent predictor of physical health QOL. Furthermore, differences in physical health QOL by gender and cancer type were not significant.

Table 3
Correlates of Physical and Mental Health Quality of Life Outcomes

In Model 2 (Table 3), the regression included interaction terms accounting for the influence of race on the relationship between psychosocial factors (stress and coping resources) and physical health QOL. The model explained 36% of the variance in physical health QOL [F(33,423) =8.68, p< .001, adjusted R2=0.357]. Despite the significant interaction between spirituality and race, inclusion of interaction terms for stress and coping resources did not improve the overall model fit [F (7,423) =1.30, p=>.05, adj R2 change =0.013], therefore Model 1 is the final model. We further examined a reduced model (not shown) including only the spirituality by race interaction. The interaction term was not significant and the model fit also did not improve significantly [F(1,429) =1.17, p >.05, adj R2 change =0.0003].

Mental Health QOL

Model 3 (Table 3) explained 36% of the variance in mental health QOL [F (26,430) =10.85, p<.001, adjusted R2=0.360]. Factors that were significantly associated with poorer mental health QOL included being African American, being unemployed, having higher levels of daily stress, having higher levels of stress associated with the diagnosis, and using more resources for coping. In contrast, higher levels of education, more perceived social support, and higher spirituality scores were associated with better mental health QOL. Finally, similar to the physical health QOL outcome, differences in mental health QOL were not significantly influenced by cancer type and gender.

In Model 4 (Table 3) results of the regression model with interaction terms are presented. The model explained 37% of the variance in mental health QOL [F (33,423) =9.23, p < .001, adjusted R2 =0.373]. Model 4 is the final model as including the interaction terms improved the model fit [F (7,423) =2.38, p< .05, adj R2 change=0.014]. There was one significant interaction. Race moderated the effect of perceived social support on mental health QOL. The difference in mental health QOL between African Americans and white survivors is represented by the value of the coefficient for the interaction (β = 1.35, p<.01). As perceived social support increased for African Americans their mental health QOL scores also increased (β=1.32, p<.001); however, this relationship was non-significant for whites (β = -0.03, p>.05). (See the Figure)

The Effect of Race on the Relationship Between Levels of Perceived Social Support and Mental Health QOL.


The overall objective of this study was to evaluate differences in physical and mental health QOL between African American and white cancer survivors and to determine the influence of sociodemographic, clinical and psychosocial factors on QOL outcomes. The majority of our study participants were well adjusted, with cancer survivors who were on average three years beyond diagnosis and treatment, reporting mental and physical health QOL scores similar to those of older adults (65-74 years) in the general U.S. population.38 These findings are consistent with recent reports suggesting that cancer-related distress resolves over time.35 However, differences in adjustment were observed based on race. First, we found that in bivariate analyses, African Americans had lower physical and mental health QOL scores. However, after adjusting for sociodemographic, clinical and psychosocial factors only racial differences in mental health QOL scores remained. Second, we found that correlates of QOL impacted racial groups similarly, except for perceived social support. Higher social support levels were associated with increased mental health QOL among African Americans, although not for white counterparts. A summary of key findings are described below and implications for treatment services discussed.

Factors Associated with Physical Health QOL

The attenuated relationship between poorer physical health QOL scores and race after adjustment for other patient characteristics are consistent with previous research highlighting the role of sociodemographic factors in outcomes of cancer patients.37 In this study, being uninsured and unemployed predicted physical health QOL, independent of race. These findings suggest that differences in cancer-related physical health outcomes are due to disparities in insurance status and treatment access. In the current study, African American cancer patients had lower education levels, were less likely to be married, and were more likely to be unemployed and lack health insurance compared with whites. These sociodemographic risk factors may increase the vulnerability of African Americans to poorer outcomes across a myriad of health disorders including physical health QOL following a cancer diagnosis.

Beyond race and sociodemographic characteristics, clinical and psychosocial factors also play a role in physical health QOL outcomes. In terms of clinical factors, we found similarities to other study findings.26,28 Not surprisingly, having a higher number of medical comorbidities was negatively associated with physical health QOL, while a longer-time since diagnosis was positively associated with physical health QOL. Unlike other studies,23,41 we did not find gender differences in physical health QOL. Research findings examining the relationship between cancer type and QOL are mixed. For example, one study found similarities in symptoms and adjustment across several different cancer types when diagnosed at early stages,42 while others have reported differences in physical health QOL based on cancer type. In a large study comparing the QOL outcomes between breast and colon cancer patients, breast cancer patients reported, on average, worse physical health-related scores.43 However, after adjustment for age, education and gender, most of the differences observed between breast and colon cancer patients disappeared. Cancer type was not associated with physical health QOL in our sample of cancer patients. It may be that other factors such as level of disease burden and the availability of appropriate clinical and psychosocial care are stronger predictors of QOL than actual cancer tumor type. However, additional research will be needed to determine which factors influence QOL outcomes in patients with differing tumor types. Several psychosocial factors measured in our study were associated with physical health QOL outcomes. For example, cancer-related stress appraisals were independent predictors of physical health QOL. Counter intuitively, higher stress at diagnosis predicted better physical health QOL in patients on average three years after being diagnosed. This finding may be influenced by unmeasured factors such as increased motivation among patients experiencing stress to engage in health promoting activities such as physical exercise. African American and white cancer patients were similar in their appraisal of the treatment experience, including the stress associated with their diagnosis. This appraisal of treatment is a critical determinant of successful coping. Specifically, appraisals of threat or harm associated with an event initiate the use of coping mechanisms.44 In a sample of patients receiving radiation therapy, appraisals mediated the effects of negative mood states, self-care burden, and reduced symptom distress.45 Another study of African American breast cancer survivors26 found that appraisals mediated the relationship between current concerns and QOL. Additional research is needed to better understand the relationship between stress appraisals and QOL outcomes by race.

Factors Associated with Mental Health QOL

Mental health QOL scores were lower for African Americans compared to whites. Unlike the physical health QOL outcome, race remained an independent predictor of mental health QOL even after controlling for other factors. Previous reports have described both poorer22 and better 2,19 mental health outcomes among African American breast and prostate cancer patients relative to white survivors. The continued significance of race in mental health outcomes after controlling for background differences suggests the influence of culture or other life experiences between African Americans and whites. Other factors may have contributed to the association between race and poorer mental health QOL. For example, social support plays an important role in emotional adjustment to illness and is thought to ameliorate psychological distress in medical patients by providing a buffer against the harmful effects of stress.46 In our study the perceived availability of support differed between racial groups, with African Americans reporting lower levels of social support, although, as levels of social support increased for African Americans, mental health QOL scores improved. This relationship did not hold among whites. Differences in levels of social support between African Americans and white patients is significant, given the association between decreased social support and increased death rate among breast cancer patients.12 These findings support the need for the assessment and provision of additional psychosocial supportive services to under-resourced African Americans with cancer. Our findings suggest that interventions to identify and increase social support levels among African American may improve their mental health QOL. In addition, understanding racial differences in patients' help-seeking and use of specific types of coping resources is an area in need of further research to help inform culturally targeted interventions for increasing adjustment to cancer and its aftermath.

Medical factors were not associated with mental health QOL, although several psychosocial factors were associated with mental health QOL outcomes as they were for physical health QOL. For example, cancer-related stress appraisals were independent predictors of mental health QOL. Higher levels of stress associated with patients' cancer diagnoses were associated with poorer mental health QOL. Higher levels of spirituality were also associated with improved mental health QOL outcomes. African Americans were more likely to report relying on their spiritual beliefs to cope with their illnesses, suggesting that higher rates of spirituality among African Americans may be important to improving their physical and emotional health following a cancer diagnosis and treatment. A review of the literature showed that strong religious beliefs were associated with lower levels of pain, anxiety, hostility, and social isolation, as well as higher levels of life satisfaction in cancer patients.47 Strong religious faith has also been linked to higher levels of QOL.48 Religion and spirituality may serve for some as a means for adjusting to a cancer diagnosis,47 much remains to be understood about the relationship between spirituality and health.49 Although the evidence is inconclusive, possible mechanisms linking psychosocial factors such as stress and coping resources to improved QOL outcomes include the body's physiological response to the stress produced by the diagnosis and the disease50 as well as behavioral pathways such as engagement in health risk behaviors.

Strengths and Limitations

This study contributes to the literature on QOL of cancer survivors by providing additional information about the QOL of African Americans. The study sample had several important strengths. First, the African American sample included cancer patients drawn from all hospitals in Illinois that reported treating 10 or greater African American patients per year. Thus, our study findings may be more generalizable than those from studies that have used samples of convenience based on one or a few hospitals. Second, each African American patient was matched as closely as possible with a white patient on demographic (i.e., gender), disease (i.e., type of cancer) and characteristics of the diagnosing hospital (i.e., bed size). Our sample of cancer survivors was also heterogeneous in terms of gender and cancer type, thus expanding our knowledge base about African Americans with cancers other than breast cancer. Finally, we measured psychosocial variables that may help to account for differences observed in QOL outcomes based on race.

Despite the strengths of the study, limitations should also be noted. Study findings are limited by the cross-sectional study design that did not allow us to examine QOL over time. Many Illinois counties were excluded from the study because they did not have any African American cancer patients, possibly under-representing white patients residing in more affluent suburban counties or in some rural areas. Comparison by race might have produced different results if we had selected a sample more representative of all white cancer patients in Illinois. Given the focus on African American patients and the importance of where patients are treated, we chose to ensure comparability on hospitals at diagnosis over greater generalizability of the white sample. The cancer registry provided health data including date of diagnosis, cancer type, time since diagnosis and the name and location of the diagnosing hospital. However, all other information was based on self-report including the presence of medical comorbidities and stage of diagnosis, which may have introduced recall bias into our findings. Furthermore, only 44% of participants had knowledge about their stage at diagnosis. Future studies should use chart reviews or other means to obtain accurate medical information on these important variables. The stress variables used in this study have been used in previous studies of primarily White cancer patients. Findings about the relationship between stress and QOL were counter-intuitive suggesting the need for additional research in this area. Although the stress measures were previously used in a large study of cancer survivors, a potential limitation of our measures of stress is that they were based on responses to three single items. It could be that the measures of stress used in this study were not sensitive measures in this population and other standardized measures of stress would be more appropriate. Finally, the focus of this study was on understanding the QOL of patients with breast, prostate and colorectal cancer. These cancer types were selected due to availability of early detection screening tests and thus the increased likelihood of longer-term cancer survivors with these diseases. Additional research is needed to measure QOL and predicting factors among African Americans with different types of cancers.


Findings have implications for better understanding of factors influencing QOL among African American and white cancer patients and may inform the development of psychosocial supportive services needed to address the general and culturally specific needs of this underserved population of cancer survivors.

Results of our findings make a significant contribution to the extant literature on race and QOL outcomes among cancer survivors and have important implications for research, treatment, and public policy. We explored the impact of a range of domains with known or theoretically plausible associations with physical and mental health outcomes for cancer survivors in general and for African American cancer survivors in particular. Identification of general and culturally-specific predictors of QOL in cancer patients has implications for developing targeted interventions that may affect outcomes and survival. Although additional research will be needed to confirm these results and to further clarify the most salient QOL issues for African Americans, our findings expand the knowledge of the cancer survivorship experience for African Americans.


This research was supported by grants from the National Cancer Institute: R01CA775-01A1 and R25CA057699. We thank participants for their time.


*The first author was at the University of Chicago, Department of Psychiatry when this project was conducted.

Conflict of Interest Disclosures: All authors have completed and submitted the LWW Copyright Transfer and Disclosure Form and no Conflicts of Interest were reported.

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Contributor Information

Dr. Alicia K. Matthews, College of Nursing, University of Illinois at Chicago, Chicago, Illinois.

Dr. Silvia Tejeda, Institute for Health Research and Policy, University of Illinois at Chicago, Chicago, Illinois.

Dr. Timothy P. Johnson, Institute for Health Research and Policy, University of Illinois at Chicago, Chicago, Illinois; Survey Research Laboratory, University of Illinois at Chicago, Chicago, Illinois.

Dr. Michael L. Berbaum, Institute for Health Research and Policy, University of Illinois at Chicago, Chicago, Illinois.

Dr. Clara Manfredi, Institute for Health Research and Policy, University of Illinois at Chicago, Chicago, Illinois.


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