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Logo of nihpaAbout Author manuscriptsSubmit a manuscriptHHS Public Access; Author Manuscript; Accepted for publication in peer reviewed journal;
 
J Am Board Fam Med. Author manuscript; available in PMC 2013 March 25.
Published in final edited form as:
PMCID: PMC3607287
NIHMSID: NIHMS447959

Is Low Education a Risk Factor for Undiagnosed Angina?

Michael M. McKee, MD, MPH,1 Paul C. Winters, MS,1 and Kevin Fiscella, MD, MPH1

Abstract

Background

Early awareness, recognition, and treatment of angina can help prevent or delay an acute myocardial infarction and potentially delay death. A patient’s educational level may affect a physician’s diagnosis of angina and/or a patient’s symptom recognition.

Objective

To determine whether low education is a risk factor for undiagnosed angina.

Design

Cross-sectional observational study (National Health and Nutrition Examination Survey 2001–2008).

Participants

Nationally representative sample of adults ≥40 years with angina based on: physician diagnosis; and/or presence of angina symptoms based on the Rose Questionnaire.

Measures

Educational attainment (high school and less vs. >high school) was the independent variable of interest. Undiagnosed angina (angina symptoms in the absence of angina diagnosis) was the dependent variable.

Methods

We used logistic regression to control for age, sex, race/ethnicity, income, and health care visit in past year.

Results

Low education was associated with undiagnosed angina (OR 1.43; 95% CI 1.01–2.03). Other undiagnosed angina predictors included being female, Black, and no health care visit in the past year.

Conclusions

Low education is associated with undiagnosed angina. These results underscore the need for providers to ask about angina symptoms and confirm patients’ understanding of their angina diagnosis among those with low education.

Keywords: Angina, Rose Questionnaire, Educational Attainment, Awareness

INTRODUCTION

Over 6 million Americans are affected by angina pectoris and it is the primary symptom in roughly half of patients with coronary artery disease (CAD).1 According to 2008 national data, 4.1% of adults reported that they were informed of an angina or CAD diagnosis.2 Early recognition and treatment of angina can help prevent or delay the onset of an acute myocardial infarction and potentially death. Yet, many lifesaving treatments such as thrombolytic therapy, aspirin and nitroglycerin are not used (or their use is delayed) due to patients’ failure to recognize cardiac symptoms.3

Low educational attainment is associated with low health literacy and also with less effective health communication, which affects patients’ abilities to convey pertinent health information to their providers. Low education is also associated with lower awareness and comprehension of physician diagnoses and recommendations.4 Adults who completed high school or less display lower literacy,5 lower health literacy,6, 7 and lower cardiac health literacy (i.e. cardiac symptom recognition).8 In a 2005 national sample, low education was associated with lower recognition of five heart attack symptoms.9 There is a growing body of evidence linking low education to worse cardiovascular outcomes.2, 1012

Given the association between low education and low cardiac health literacy, we hypothesized that individuals with low education would more often report angina symptoms that were undiagnosed than would those with higher education.

METHODS

Sample

We used 2001–2008 data from the National Health and Nutrition Examination Survey (NHANES), a nationally representative, stratified multi-stage probability sample of the civilian non-institutionalized population of the United States. Since 1999, NHANES has been conducted on a continuous basis, with data released in two-year cycles. Data collection methods include an interviewer-administered questionnaire using Computer-Assisted Personal Interview (CAPI) technology and physical exams performed in Mobile Examination Centers. In addition, NHANES over-sampled African Americans, Hispanics, and persons aged 60 years and older.13 Our study sample included 1,028 adults (497 males and 531 females) aged 40 years and older with either diagnosed or undiagnosed angina (details provided below) with complete data on age, race, sex, income and healthcare variables.

Measures

Angina

We assessed angina in two ways. The first was based on an affirmative response to the question: "Has a doctor or other health professional ever told you that you had angina, also called angina pectoris?"

The second was based on the presence of angina symptoms using the Rose Questionnaire.14 The Rose Questionnaire is a standardized and validated assessment tool designed to differentiate cardiac from non-cardiac chest pain. It has been used widely in a variety of cardiovascular epidemiological studies over the past several decades10, 15 within multiple countries, and among persons of different races, gender, languages, educational levels and occupations.10, 1619 It has fair sensitivity and specificity for angina compared to various clinical assessments: clinical judgment (sensitivity of 81% and specificity of 97%),16 thallium scintigraphy (sensitivity of 40–50% and specificity of 56–77%),20, 21 coronary angiography (sensitivity of 50% and specificity of 75%),22 and exercise electrocardiography (sensitivity of 57% and specificity of 47%).22

The nine questions for the Rose Questionnaire are shown in Figure 1.

Figure 1
Rose Questionnaire

We used NHANES criteria to identify those with angina based on responses to this questionnaire: chest pain or discomfort (yes to question 1) that fulfilled all of the following criteria: (a) was brought on by exertion (yes to either question 2 and/or 3); (b) forced the subject to slow down or stop (question 4); (c) was relieved if the subject did so (yes to question 5), (d) was relieved within 10 minutes (question 6), (e) was located in the central or left anterior chest (question 9).

Undiagnosed Angina (dependent variable)

We defined undiagnosed angina based on the presence of angina symptoms in the absence of a physician diagnosis.

Low Education (independent variable)

Self-reported educational attainment was our main independent variable. We operationalized it as high school education or less (low education) vs. greater than high school education (referent).

Covariates

We included self-reported demographic covariates: age (40 – 54 years, 55 – 64 years, 65+ years); sex (male, female); race/ethnicity (Mexican American/Other Hispanic, Non-Hispanic White, Non-Hispanic Black, Other race) and family poverty income ratio (federal poverty income thresholds that account for household size). We assessed health care access based on the participant’s reporting whether they had seen a doctor/health professional in the past year (yes/no).

Statistical Analysis

NHANES uses a complex sampling design involving stratification, clustering, and over-sampling of certain groups resulting in unequal probability of selection. The statistical analyses incorporated stratum, primary sampling units, and appropriate interview sampling weights to produce unbiased estimates of the non-institutionalized U.S. population.23 We used a subpopulation statement in SUDAAN to generate estimates for the U.S. population, aged 40 and older. Bivariate associations were determined using chi-square tests. We assessed the independent association between low education and undiagnosed angina using logistic regression that controlled for demographics (sex, age, race/ethnicity, income and education) and a healthcare-related variable (health care in past year). All statistical analyses were conducted using SAS-callable SUDAAN Version 10.0.1 and SAS Version 9.2.

RESULTS

The final sample included 1,028 adults of whom 359 had angina symptoms but reported no past diagnosis of angina reported by their physicians. Persons with undiagnosed angina were younger, more often female, Black, and less likely to have seen a physician/health care professional in the past year compared to those without undiagnosed angina (Table 1). In an adjusted analysis, low education was significantly associated (Odds Ratio [OR] 1.43; 95% Confidence Interval [CI] 1.01–2.03) with undiagnosed angina (Table 2). Other significant predictors of undiagnosed angina included being female (OR 1.95; 95% CI 1.36–2.81), Black (OR 2.56; 95% CI 1.67–3.93), and not having seen a physician/health care professional in the past year (OR, 2.81; 95% CI 1.53–5.16). There were no significant interactions between education and other variables in the model.

Table 1
Characteristics of participants with undiagnosed and diagnosed angina.
Table 2
Predictors of undiagnosed angina.

We examined the extent to which having had a health care visit in the past year affected our findings. When we excluded this variable from our model, there was little change in the risk associated with low education (OR 1.44; 95% CI 1.02 – 2.03).

DISCUSSION

In national survey of adults 40 and older, we found that low education was associated with a 43% greater likelihood of undiagnosed angina. These effects persisted after controlling for age, sex, race, income and having a physician visit in the past year. These findings are consistent with previous studies suggesting that low education may pose an awareness and health communication issue, resulting in possible diagnosis errors and treatment delays.24, 25 To our knowledge, these findings, based on national data using a validated measure for angina symptoms, are novel.

Our data do not indicate why low education is associated with undiagnosed angina symptoms. Our analysis controlled for having had a visit with health care provider within the past year, so having a recent physician visit is unlikely to be the sole explanation. Potentially, this association reflects low patient health literacy and resulting breakdowns in patient-provider communication. There is a strong association between low education and low health literacy.6, 7, 26 Patients with low education are less likely to associate angina symptoms with heart disease.8, 9 Clinicians may not appreciate that patients with low education are describing angina or to clearly communicate their diagnosis to the patients. Physicians often use medical jargon that is poorly understood, particularly by patients with low health literacy.27, 28 Other communication barriers include limited patient knowledge, patient embarrassment regarding asking questions, and suboptimal physician communication behavior.29 When caring for patients with low education, physicians tend to listen less, provide less reassurance, underestimate the information patients desire, fail to engage the patient in shared-decision making, offer patients too little health information, and display less empathy.30, 31 For these reasons, we suspect that our results may reflect communication failures between physicians and their patients with low education.

Other patient demographic characteristics besides low education are also significantly associated with undiagnosed angina. These include being female, Black, and not having seen a physician/health care professional in the past year. Although these reflect post-hoc findings warranting replication through further study, they suggest that clinicians be especially attuned to unrecognized angina among these groups.

Less than 20% of females over the age of 35 are aware that cardiovascular disease is a major cause of death for females.32 The Atherosclerosis Risk in Communities study which used the Rose Questionnaire also revealed higher rates of angina among females compared to males.33 Undiagnosed angina may be attributable to the language used in physician-patient encounters and inaccurate physician beliefs. Females ask more questions than men and try to retrieve more medical information, yet are less likely to be diagnosed as suffering from cardiovascular disease and are more likely to have their symptoms attributed to emotional or psychosomatic causes.34

Despite higher burdens in cardiovascular diseases, Blacks lag behind Whites in cardiovascular disease recognition and awareness.2, 33 Cardiovascular disparities among Blacks are largely attributable to lower educational attainments and more risk factors, particularly hypertension.11

Individuals over 55 years of age were less likely to have undiagnosed angina compared to individuals aged 40–54 years. This may be explained by several factors. Increasing age is associated with greater risk for cardiovascular disease, including angina.2 The association of older age with greater diagnosis likely increases cardiovascular awareness among individuals in this age group. In addition, physicians may also have higher suspicion for angina and cardiovascular diseases in this age group.

Low education is associated with higher risk of developing angina and worse treatment and survival rates for both fatal and nonfatal cardiac events.1 Thus, it is critical for physicians to be cognizant of the communication needs of persons with low education and to employ principles of clear communication, including teach-back.35, 36 Specifically, providers and staff can communicate more effectively with less educated patients through the following steps: providing patients with adequate time and opportunities to voice their concerns and symptoms; showing respect including listening attentively; encouraging the patient to ask follow-up questions; rephrasing complex questions or terms into plain language; using appropriate pictures and graphics to enhance patients’ comprehension of the material being discussed; encouraging the patient to explain their understanding in their own words;37 and actively engaging the patient in decision making.

Health information provided by physicians can be reinforced through public health programs and community outreaches that target persons with low education using simple and informative health messages about cardiac symptoms. Information should also include steps to take if cardiac symptoms occur including contacting emergency medical services immediately.38

Our findings are subject to several limitations. Data are self-reported and potentially subject to recall and reporting bias. No cause and effect can be established due to the nature of the cross-sectional design. We cannot pinpoint where breakdowns in communication occurred. Further study is needed to determine whether higher prevalence of unrecognized angina among those with low education results from patients failing to report symptoms or from clinicians failing to ask and/or recognize symptoms.

Most participants likely completed their formal education more than 20 years ago. However, the effect of educational attainment on literacy persists over time. National data show a similar pattern between years of education and reading ability regardless of age.39 Finally, we cannot exclude the possibility that other factors not accounted for in our model may be confounded with our results.

CONCLUSION

Our findings show that among a national sample of adults with presumed angina, low education is associated with undiagnosed angina. Potentially, this may contribute to worse cardiovascular outcomes for this group. Additional research is also needed to determine the reasons why low education is associated with undiagnosed angina and which interventions are mostly likely to improve diagnosis. Physicians should ask about the presence of angina symptoms, particularly among adults with low education, including females, Blacks and those who have not received health care in the past year.

Acknowledgments

The research was supported by the National Heart Lung and Blood Institute (1R01 HL081066-01A2). Its contents are solely the responsibility of the authors and do not necessarily represent the official views of the NHLBI. Dr. McKee is currently supported by grant K01 HL103140-01 from the National Heart, Lung, and Blood Institute (NHLBI) of the National Institutes of Health (NIH).

Funding:

Footnotes

Conflict of Interest Statement:

Michael McKee, MD, MPH has no financial disclosures.

Paul Winters, MS has no financial disclosures.

Kevin Fiscella, MD, MPH has no financial disclosures.

References

1. Mozaffarian D, Byrson CL, Spertus JA, McDonell MB, Fihn SD. Anginal symptoms consistently predict total mortality among outpatients with coronary artery disease. Am Heart J. 2003;146(6):1015–1022. [PubMed]
2. Lloyd-Jones D, Adams RJ, Brown TM, et al. Heart disease and stroke statistics--2010 update: a report from the American Heart Association. Circulation. 2010;121(7):e46–e215. [PubMed]
3. Dracup K, Moser DK, Eisenberg M, Meischke H, Alonzo AA, Braslow A. Causes of delay in seeking treatment for heart attack symptoms. Soc Sci Med. 1995;40:379–392. [PubMed]
4. Smith SK, Dixon A, Trevena L, Nutbeam D, McCaffery KJ. Exploring patient involvement in healthcare decision making across different education and functional health literacy groups. Soc Sci Med. 2009;69(12):1805–1812. [PubMed]
5. Kirsch IS, Jungeblut A, Jenkins L, Kolstad A. Adult Literacy in America: A First Look at the Findings of the National Adult Literacy Survey: Department of Education. 2002
6. Berkman ND, DeWalt DA, Pignone MP, Sheridan SL, Lohr KN, Lux L, Sutton SF, Swinson T, Bonito AJ. Literacy and Health Outcomes. Rockville, MD: Agency for Health Care Research and Quality; 2004.
7. Kutner MGE, Jin Y, Paulsen C. The Health Literacy of America’s Adults: Results From the 2003 National Assessment of Adult Literacy. Washington, DC: National Center for Education Statistics; 2006.
8. Safeer RS, Cooke CE, Keenan J. The impact of health literacy on cardiovascular disease. Vasc Health Risk Manag. 2006;2(4):457–464. [PMC free article] [PubMed]
9. Centers for Disease Control and Prevention (CDC). Disparities in adult awareness of heart attack warning signs and symptoms: 14 states, 2005. MMWR Morb Mortal Wkly Rep. 2008;57:175–179. [PubMed]
10. Reeder B, Lui L, Horlick L. Sociodemographic variation in the prevalence of cardiovascular disease. Can J Cardiol. 1996;12(3):271–277. [PubMed]
11. Hozawa A, Folsom A, Sharrett A, Chambless L. Absolute and attributable risks of cardiovascular disease incidence in relation to optimal and borderline risk factors: comparison of African American with white subjects: Atherosclerosis Risk in Communities Study. Arch Intern Med. 2007;167:573–579. [PubMed]
12. Centers for Disease Control and Prevention (CDC). Receipt of outpatient cardiac rehabilitation among heart attack survivors—United States, 2005. MMWR Morb Mortal Wkly Rep. 2008;57:89–94. [PubMed]
13. Centers for Disease Control and Prevention (CDC) Hyattsville, MD: National Center for Health Statistics Centers for Disease Control and Prevention; 2006. Analytic and Reporting Guidelines: The National Health and Nutrition Examination Survey (NHANES)
14. Rose GA. Ischemic heart disease. Chest pain questionnaire. Milbank Mem Fund Q. 1965;43:32–39. [PubMed]
15. Rose G. The diagnosis of ischaemic heart pain and intermittent claudication in field surveys. Bull World Health Organ. 1962;27:645–658. [PubMed]
16. Heyden S, Bartel A, Tabesh E, Cassel J, Tyroler H, Cornoni J, Hames C. Angina Pectoris and the Rose Questionnaire. Arch Intern Med. 1971;128:961–964. [PubMed]
17. Graff-Iversen S, Selmer R, Løchen M. Rose angina predicts 23-year coronary heart disease mortality in women and men aged 40–49 years. Heart. 2007;94:482–486. [PubMed]
18. Lacrolx A, Haynes S, Savage D, Havlik R. Rose Questionnaire Angina among United States Black, White and Mexican-American Women and Men Prevalence and Correlates from the Second National and Hispanic Health and Nutrition Examination Surveys. Am J Epidemiol. 1989;129(4):669–686. [PubMed]
19. Prabhakaran D, Shah P, Chaturvedi V, Ramakrishnan L, Manhapra A, Reddy K. Cardiovascular risk factor prevalence among men in a large industry of northern India. Natl Med J India. 2005;18(2):59–65. [PubMed]
20. Bass E, Follansbee WP, Orchard TJ. Comparison of a supplemented Rose questionnaire to exercise-thallium testing in men and women. J Clin Epidemiol. 1989;42:385–394. [PubMed]
21. Garber C, Carleton RA, Heller GV. Comparison of "Rose questionnaire angina" to exercise-thallium scintigraphy; different findings in males and females. J Clin Epidemiol. 1992;45(7):15–20. [PubMed]
22. Midwall J, Ambrose J, Pichard A, Abedin Z, Hermanj MV. Angina pectoris before and after myocardial infarction: angiographic correlations. Chest. 1982;81:681. [PubMed]
23. National Center for Health Statistics. The National Health and Nutrition Examination Survey (NHANES) Analytic and Reporting Guidelines. [Accessed 15 August, 2011];2006 http://www.cdc.gov/nchs/data/nhanes/nhanes_03_04/nhanes_analytic_guidelines_dec_2005.pdf.
24. Gazmararian JA, Williams MV, Peel J, Baker DW. Health literacy and knowledge of chronic disease. Patient Educ Couns. 2003;51(3):267–275. [PubMed]
25. DeWalt DA, Boone RS, Pignone MP. Literacy and its relationship with self-efficacy, trust, and participation in medical decision making. Am J Health Behav. 2007;(1) Suppl:S27–S35. [PubMed]
26. Gazmararian JA, Curran JW, Parker RM, Bernhardt JM, DeBuono BA. Public health literacy in America: an ethical imperative. Am J Prev Med. 2005;28(3):317–322. [PubMed]
27. Lerner E, Jehle D, Janicke D, Moscati R. Medical communication: do our patients understand? Am J Emerg Med. 2000;18(7):764–766. [PubMed]
28. Spiro D, Heidrich F. Lay understanding of medical terminology. J Fam Pract. 1983;17(2):277–279. [PubMed]
29. Nielsen-Bohlman L, Panzer A, Kindig D, editors. Health Literacy: A Prescription to End Confusion. Washington, D.C.: The National Academies Press; 2004.
30. Willems S, De Maesschalck S, Deveugele M, Derese A, De Maeseneer J. Socio-economic status of the patient and doctor-patient communication: does it make a difference? Patient Educ Couns. 2005;56(2):139–146. [PubMed]
31. Fiscella K, Goodwin M, Stange K. Does patient educational level affect office visits to family physicians? J Natl Med Assoc. 2002;94(3):157–165. [PMC free article] [PubMed]
32. Biswas MS, Calhous PS, Bosworth HB, Bastian LA. Are women worrying about heart disease? Womens Health Issues. 2002;12:204–211. [PubMed]
33. National Heart, Lung, and Blood Institute. Incidence and Prevalence: 2006 Chart Book on Cardiovascular and Lung Diseases. Bethesda, MD: National Institute of Health; 2006.
34. Philpott S, Boynton PM, Feder G, Hemingway H. . Gender differences in descriptions of angina symptoms and health problems immediately prior to angiography: the ACRE study. Appropriateness of Coronary Revascularisation study. Soc Sci Med. 2001;52(10):1565–1575. [PubMed]
35. National Quality Forum. Safe Practices for Better Healthcare. Washington, DC: National Quality Forum; 2003.
36. Kripalani S, Weiss B. Teaching about Health Literacy and Clear Communication. J Gen Intern Med. 2006;21(8):888–890. [PMC free article] [PubMed]
37. Schillinger D, Piette J, Grumbach K, Wang F, Wilson C, Daher C, Leong-Grotz K, Castro C, Bindman A. Physician Communication With Diabetic Patients Who Have Low Health Literacy. Arch Intern Med. 2003;163:83–90. [PubMed]
38. Dracup K, Alonzo AA, Atkins JM, et al. The Physician's Role in Minimizing Prehospital Delay in Patients at High Risk for Acute Myocardial Infarction: Recommendations from the National Heart Attack Alert Program. Ann Intern Med. 1997;126:645–651. [PubMed]
39. Kaestle C, Campbell A, Finn J, Johnson S, Mikulecky L. Washington, DC: National Center for Education Statistics; 2001. Adult Literacy and Education in America: Four Studies Based on the National Adult Literacy Survey.