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Logo of nihpaAbout Author manuscriptsSubmit a manuscriptHHS Public Access; Author Manuscript; Accepted for publication in peer reviewed journal;
Nat Chem Biol. Author manuscript; available in PMC 2013 October 1.
Published in final edited form as:
Nat Chem Biol. 2013 April; 9(4): 257–263.
Published online 2013 February 10. doi: 10.1038/nchembio.1183

Figure 2

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Optovin structure activity relationship analysis

(a) Horizontal bar plot showing behavioral excitation scores from groups treated with the indicated optovin analogs (n=5). Optovin, 6b8, 6c1, 6c4 and 4g6 analogs are active; 6c5, 6c7,6c2, and 6c3 are inactive. Differences between active and inactive groups are significant, p<0.001. Structures of the analogs are shown to the left of the bar plot. All compounds were tested at 10 μM, except for the 4g6 analog, which was tested at 100 μM. (b) Example responses from the indicated groups. Red vertical lines indicate light stimuli. Green horizontal lines indicate the off-latency duration for motor responses following each stimulus. (c) Bar plot showing average behavioral response duration of groups treated with the indicated optovin analogs. Values are means ± standard deviations (n=5). Differences between optovin and 4g6 and 6b8 are significant, p<0.01.

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