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Logo of nihpaAbout Author manuscriptsSubmit a manuscriptHHS Public Access; Author Manuscript; Accepted for publication in peer reviewed journal;
J Med Chem. Author manuscript; available in PMC 2013 March 11.
Published in final edited form as:
J Med Chem. 2010 April 8; 53(7): 2836–2842.
doi: 10.1021/jm100135g

Figure 2

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Bimolecular fluorescence complementation. Shown are representative epifluorescence images of COS cells expressing the indicated receptor constructs. Microscopic images show the effective physical complementation of YN-tagged receptor and YC-tagged receptor to yield fluorescent YFP. These observations support the previous reports of constitutive homo-oligomerization of the CCK2 and MOP receptors.9 No YFP fluorescence complementation was observed when the complementarily tagged CCK2 and MOP receptors were coexpressed, again supporting the previous BRET study showing absence of hetero-oligomerization.9 Scale bar: 25 μm.

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