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Clin Microbiol Rev. 1991 July; 4(3): 243–255.
PMCID: PMC358197

Human infections associated with Bordetella bronchiseptica.


This study examines the potential of Bordetella bronchiseptica to act as a human pathogen. After encountering two patients from whom B. bronchiseptica was isolated, we searched the literature and found 23 reports in which a human infection was reported in association with B. bronchiseptica. As a basis for evaluating these cases, we summarize the literature about the current microbiological status of B. bronchiseptica, the pathology and pathogenic mechanisms associated with the microorganism, and the likelihood of it acting as a commensal or colonizer. From this review we conclude that B. bronchiseptica has been rarely isolated from humans despite their considerable exposure to animal sources. Evidence suggests that B. bronchiseptica may be rarely encountered as a commensal or colonizer of the respiratory tract of humans and rarely in association with infection. When found as a probable pathogen, most infections have been respiratory tract in origin and have occurred in severely compromised hosts.

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  • Alexander TJ, Thornton K, Boon G, Lysons RJ, Gush AF. Medicated early weaning to obtain pigs free from pathogens endemic in the herd of origin. Vet Rec. 1980 Feb 9;106(6):114–119. [PubMed]
  • Appelbaum PC, Leathers DJ. Evaluation of the rapid NFT system for identification of gram-negative, nonfermenting rods. J Clin Microbiol. 1984 Oct;20(4):730–734. [PMC free article] [PubMed]
  • Appelbaum PC, Tamim J, Pankuch GA, Aber RC. Susceptibility of 324 nonfermentative gram-negative rods to 6 cephalosporins and azthreonam. Chemotherapy. 1983;29(5):337–344. [PubMed]
  • Bäckström LR, Brim TA, Collins MT. Development of turbinate lesions and nasal colonization by Bordetella bronchiseptica and Pasteurella multocida during long-term exposure of healthy pigs to pigs affected by atrophic rhinitis. Can J Vet Res. 1988 Jan;52(1):23–29. [PMC free article] [PubMed]
  • Barnishan J, Ayers LW. Rapid identification of nonfermentative gram-negative rods by the Corning N/F system. J Clin Microbiol. 1979 Feb;9(2):239–243. [PMC free article] [PubMed]
  • Batey RG, Smits AF. The isolation of Bordetella bronchiseptic from an outbreak of canine pneumonia. Aust Vet J. 1976 Apr;52(4):184–186. [PubMed]
  • Bemis DA, Carmichael LE, Appel MJ. Naturally occurring respiratory disease in a kennel caused by Bordetella bronchiseptica. Cornell Vet. 1977 Apr;67(2):282–293. [PubMed]
  • Bemis DA, Greisen HA, Appel MJ. Bacteriological variation among Bordetella bronchiseptica isolates from dogs and other species. J Clin Microbiol. 1977 Apr;5(4):471–480. [PMC free article] [PubMed]
  • Bemis DA, Greisen HA, Appel MJ. Pathogenesis of canine bordetellosis. J Infect Dis. 1977 May;135(5):753–762. [PubMed]
  • Bemis DA, Plotkin BJ. Hemagglutination by Bordetella bronchiseptica. J Clin Microbiol. 1982 Jun;15(6):1120–1127. [PMC free article] [PubMed]
  • Bemis DA, Wilson SA. Influence of potential virulence determinants on Bordetella bronchiseptica-induced ciliostasis. Infect Immun. 1985 Oct;50(1):35–42. [PMC free article] [PubMed]
  • Bercovich Z, De Jong MF. Enkele profylactische en therapeutische maatregelen tegen atrofische rhinitis bij de big onder praktijkomstandigheden. Tijdschr Diergeneeskd. 1977 Apr 1;102(7):448–455. [PubMed]
  • Bercovich Z, Oosterwoud RA. Vaccination with Bordetella bronchiseptica vaccine on a farm with atrophic rhinitis: an evaluation of a field experiment. Tijdschr Diergeneeskd. 1977 Apr 15;102(8):485–494. [PubMed]
  • Bradford WL, Slavin B. An Organism Resembling Hemophilus Pertussis: With Special Reference to Color Changes Produced by Its Growth Upon Certain Media. Am J Public Health Nations Health. 1937 Dec;27(12):1277–1282. [PubMed]
  • Brooksaler F, Nelson JD. Pertussis. A reappraisal and report of 190 confirmed cases. Am J Dis Child. 1967 Oct;114(4):389–396. [PubMed]
  • Brown WR, Krook L, Pond WG. Atrophic rhinitis in swine. Etiology, pathogenesis, and prophylaxis. Cornell Vet. 1966 Apr;56(Suppl):3–108. [PubMed]
  • Buggy BP, Brosius FC, 3rd, Bogin RM, Koller CA, Schaberg DR. Bordetella bronchiseptica pneumonia in a patient with chronic lymphocytic leukemia. South Med J. 1987 Sep;80(9):1187–1189. [PubMed]
  • Byrd LH, Anama L, Gutkin M, Chmel H. Bordetella bronchiseptica peritonitis associated with continuous ambulatory peritoneal dialysis. J Clin Microbiol. 1981 Aug;14(2):232–233. [PMC free article] [PubMed]
  • Chang KC, Zakhein RM, Cho CT, Montgomery JC. Letter: Posttraumatic purulent meningitis due to Bordetella bronchiseptica. J Pediatr. 1975 Apr;86(4):639–640. [PubMed]
  • SHIH MAN C. Pertussis due to Brucella bronchoseptica; case report. Pediatrics. 1950 Aug;6(2):227–228. [PubMed]
  • Chanter N, Magyar T, Rutter JM. Interactions between Bordetella bronchiseptica and toxigenic Pasteurella multocida in atrophic rhinitis of pigs. Res Vet Sci. 1989 Jul;47(1):48–53. [PubMed]
  • Chanter N, Rutter JM, Mackenzie A. Partial purification of an osteolytic toxin from Pasteurella multocida. J Gen Microbiol. 1986 Apr;132(4):1089–1097. [PubMed]
  • Confer DL, Eaton JW. Phagocyte impotence caused by an invasive bacterial adenylate cyclase. Science. 1982 Sep 3;217(4563):948–950. [PubMed]
  • Cooper RG, Gibbs MH. The antibiotic sensitivity of Bordetella in South Australia. Med J Aust. 1967 Nov 4;2(19):843–843. [PubMed]
  • Cowart RP, Bäckström L, Brim TA. Pasteurella multocida and Bordetella bronchiseptica in atrophic rhinitis and pneumonia in swine. Can J Vet Res. 1989 Jul;53(3):295–300. [PMC free article] [PubMed]
  • CROSS RF. Bordetella bronchiseptica-induced porcine atrophic rhinitis. J Am Vet Med Assoc. 1962 Dec 15;141:1467–1468. [PubMed]
  • Deeb BJ, DiGiacomo RF, Bernard BL, Silbernagel SM. Pasteurella multocida and Bordetella bronchiseptica infections in rabbits. J Clin Microbiol. 1990 Jan;28(1):70–75. [PMC free article] [PubMed]
  • DiGiacomo RF, Deeb BJ, Giddens WE, Jr, Bernard BL, Chengappa MM. Atrophic rhinitis in New Zealand white rabbits infected with Pasteurella multocida. Am J Vet Res. 1989 Sep;50(9):1460–1465. [PubMed]
  • DiGiacomo RF, Garlinghouse LE, Jr, Van Hoosier GL., Jr Natural history of infection with Pasteurella multocida in rabbits. J Am Vet Med Assoc. 1983 Dec 1;183(11):1172–1175. [PubMed]
  • Dominick MA, Rimler RB. Turbinate atrophy in gnotobiotic pigs intranasally inoculated with protein toxin isolated from type D Pasteurella multocida. Am J Vet Res. 1986 Jul;47(7):1532–1536. [PubMed]
  • DONCHEV D, STOYANOVA M. The epidemiological significance of the differentiation of pertussis and parapertussis. J Hyg Epidemiol Microbiol Immunol. 1961;5:294–297. [PubMed]
  • Duncan JR, Ramsey FK. Fine structural changes in the porcine nasal ciliated epithelial cell produced by Bordetella bronchiseptica rhinitis. Am J Pathol. 1965 Oct;47(4):601–612. [PubMed]
  • Duncan JR, Ramsey RK, Switzer WP. Pathology of experimental Bordetella bronchiseptica infection in swine: pneumonia. Am J Vet Res. 1966 Mar;27(117):467–472. [PubMed]
  • Duncan JR, Ross RF, Switzer WP, Ramsey FK. Pathology of experimental Bordetella bronchiseptica infection in swine: atrophic rhinitis. Am J Vet Res. 1966 Mar;27(117):457–466. [PubMed]
  • DUNNE HW, KRADEL DC, DOTY RB. Bordetella bronchiseptica (Brucella bronchiseptica) in pneumonia in young pigs. J Am Vet Med Assoc. 1961 Oct 15;139:897–899. [PubMed]
  • Eldering G, Holwerda J, Davis A, Baker J. Bordetella pertussis serotypes in the United States. Appl Microbiol. 1969 Oct;18(4):618–621. [PMC free article] [PubMed]
  • Cieślik R. Gojenie sie zeszytych i nie zeszytych ubytków otrzewnej ściennej. Pol Przegl Chir. 1979 Dec;51(12):1179–1186. [PMC free article] [PubMed]
  • ELDERING G, KENDRICK PL. Incidence of parapertussis in the Grand Rapids area as indicated by 16 years' experience with diagnostic cultures. Am J Public Health Nations Health. 1952 Jan;42(1):27–31. [PubMed]
  • Elling F, Pedersen KB. The pathogenesis of persistent turbinate atrophy induced by toxigenic Pasteurella multocida in pigs. Vet Pathol. 1985 Sep;22(5):469–474. [PubMed]
  • Endoh M, Amitani M, Nakase Y. Purification and characterization of heat-labile toxin from Bordetella bronchiseptica. Microbiol Immunol. 1986;30(7):659–673. [PubMed]
  • Endoh M, Takezawa T, Nakase Y. Adenylate cyclase activity of Bordetella organisms. I. Its production in liquid medium. Microbiol Immunol. 1980;24(2):95–104. [PubMed]
  • Farrington DO, Switzer WP. Parenteral vaccination of young swine against Bordetella bronchiseptica. Am J Vet Res. 1979 Oct;40(10):1347–1351. [PubMed]
  • Fass RJ, Barnishan J. In vitro susceptibilities of nonfermentative gram-negative bacilli other than Pseudomonas aeruginosa to 32 antimicrobial agents. Rev Infect Dis. 1980 Nov-Dec;2(6):841–853. [PubMed]
  • Gardner P, Griffin WB, Swartz MN, Kunz LJ. Nonfermentative gram-negative bacilli of nosocomial interest. Am J Med. 1970 Jun;48(6):735–749. [PubMed]
  • Ghosh HK, Tranter J. Bordetella bronchicanis (bronchiseptica) infection in man: review and a case report. J Clin Pathol. 1979 Jun;32(6):546–548. [PMC free article] [PubMed]
  • Giles CJ, Smith IM, Baskerville AJ, Brothwell E. Clinical bacteriological and epidemiological observations on infectious atrophic rhinitis of pigs in southern England. Vet Rec. 1980 Jan 12;106(2):25–28. [PubMed]
  • Goodnow RA. Control of atrophic rhinitis with a Bordetella bronchiseptica bacterin. Vet Med Small Anim Clin. 1977 Jul;72(7):1210–1212. [PubMed]
  • Goodnow RA. Biology of Bordetella bronchiseptica. Microbiol Rev. 1980 Dec;44(4):722–738. [PMC free article] [PubMed]
  • Goodnow RA, Lehr CD, McLennan J. Effect of immunization with a Bordetella bronchiseptica bacterin on weight gain in weaning pigs. Vet Med Small Anim Clin. 1978 Sep;73(9):1187–1188. [PubMed]
  • Goodnow RA, Shade FJ, Switzer WP. Efficacy of Bordetella bronchiseptica bacterin in controlling enzootic atrophic rhinitis in swine. Am J Vet Res. 1979 Jan;40(1):58–60. [PubMed]
  • GOODWIN RF, WHITTLESTONE P. A respiratory disease of pigs (type XI) differing from enzootic pneumonia. The field disease. J Comp Pathol. 1962 Oct;72:389–410. [PubMed]
  • Granström M, Askelöf P. Parapertussis: an abortive pertussis infection? Lancet. 1982 Dec 4;2(8310):1249–1250. [PubMed]
  • Groom SC, Hazlett MJ, Little PB. An evaluation of the API ZYM system as a means of identifying Haemophilus somnus and related taxa. Can J Vet Res. 1986 Apr;50(2):238–244. [PMC free article] [PubMed]
  • Hanada M, Shimoda K, Tomita S, Nakase Y, Nishiyama Y. Production of lesions similar to naturally occurring swine atrophic rhinitis by cell-free sonicated extract of Bordetella bronchiseptica. Nihon Juigaku Zasshi. 1979 Feb;41(1):1–8. [PubMed]
  • Harris DL, Switzer WP. Turbinate atrophy in young pigs exposed to Bordetella bronchiseptica, Pasteurella multocida, and combined inoculum. Am J Vet Res. 1968 Apr;29(4):777–785. [PubMed]
  • Harris DL, Switzer WP. Nasal and tracheal resistance of swine against reinfection by Bordetella bronchiseptica. Am J Vet Res. 1969 Jul;30(7):1161–1166. [PubMed]
  • Harris DL, Switzer WP. Immunization of pigs against Bordetella bronchiseptica infection by parenteral vaccination. Am J Vet Res. 1972 Oct;33(10):1975–1984. [PubMed]
  • Harris DL, Switzer WP, Harris RA. A suggested mechanism for the pathogenesis of infectious atrophic rhinitis. Can J Comp Med. 1971 Oct;35(4):318–323. [PMC free article] [PubMed]
  • Harris RA, Harris DL, Green DE. Effect of Bordetella endotoxin upon mitochondrial respiration and energized processes. Arch Biochem Biophys. 1968 Oct;128(1):219–230. [PubMed]
  • Hoidal JR, Beall GD, Rasp FL, Jr, Holmes B, White JG, Repine JE. Comparison of the metabolism of alveolar macrophages from humans, rats, and rabbits: phorbol myristate acetate. J Lab Clin Med. 1978 Nov;92(5):787–794. [PubMed]
  • Horiguchi Y, Nakai T, Kume K. Purification and characterization of Bordetella bronchiseptica dermonecrotic toxin. Microb Pathog. 1989 May;6(5):361–368. [PubMed]
  • Ishikawa H, Isayama Y. Evidence for sialyl glycoconjugates as receptors for Bordetella bronchiseptica on swine nasal mucosa. Infect Immun. 1987 Jul;55(7):1607–1609. [PMC free article] [PubMed]
  • JONES M. Subacute bacterial endocarditis of nonstreptococcic etiology; a review of the literature of the thirteen-year period 1936-1948 inclusive. Am Heart J. 1950 Jul;40(1):106–116. [PubMed]
  • Katzenstein DA, Ciofalo L, Jordan MC. Bordetella bronchiseptica bacteremia. West J Med. 1984 Jan;140(1):96–98. [PMC free article] [PubMed]
  • KREPLER P, FLAMM H. Bordetella bronchiseptica als Erreger menschlicher Erkrankungen. Wien Klin Wochenschr. 1958 Aug 29;70(35):641–644. [PubMed]
  • KRISTENSEN KH, LAUTROP H. [A family epidemic caused by the whooping-cough bacterium Bordetella bronchiseptica]. Ugeskr Laeger. 1962 Mar 9;124:303–308. [PubMed]
  • Kume K, Nakai T, Samejima Y, Sugimoto C. Properties of dermonecrotic toxin prepared from sonic extracts Bordetella bronchiseptica. Infect Immun. 1986 May;52(2):370–377. [PMC free article] [PubMed]
  • Kurzynski TA, Boehm DM, Rott-Petri JA, Schell RF, Allison PE. Antimicrobial susceptibilities of Bordetella species isolated in a Multicenter Pertussis Surveillance Project. Antimicrob Agents Chemother. 1988 Jan;32(1):137–140. [PMC free article] [PubMed]
  • Lautrop H. Epidemics of parapertussis. 20 years' observations in Denmark. Lancet. 1971 Jun 12;1(7711):1195–1198. [PubMed]
  • Linnemann CC, Perry EB. Bordetella parapertussis. Recent experience and a review of the literature. Am J Dis Child. 1977 May;131(5):560–563. [PubMed]
  • Little TW. Respiratory disease in pigs: a study. Vet Rec. 1975 Jun 21;96(25):540–544. [PubMed]
  • MACLENNAN AP. Specific lipopolysaccharides of Bordetella. Biochem J. 1960 Feb;74:398–409. [PubMed]
  • Maeda M, Shimizu T. Nasal infection of Alcaligenes bronchisepticus (Bordetella bronchiseptica) and lesions in newborn rabbits. Natl Inst Anim Health Q (Tokyo) 1975 Spring;15(1):29–37. [PubMed]
  • Matsuyama T, Takino T. Scanning electronmicroscopic studies of Bordetella bronchiseptica on the rabbit tracheal mucosa. J Med Microbiol. 1980 Feb;13(1):159–161. [PubMed]
  • Moore CJ, Mawhinney H, Blackall PJ. Differentiation of Bordetella avium and related species by cellular fatty acid analysis. J Clin Microbiol. 1987 Jun;25(6):1059–1062. [PMC free article] [PubMed]
  • Morrison RB, Pijoan C, Hilley HD, Rapp V. Microorganisms associated with pneumonia in slaughter weight swine. Can J Comp Med. 1985 Apr;49(2):129–137. [PMC free article] [PubMed]
  • Mortensen JE, Brumbach A, Shryock TR. Antimicrobial susceptibility of Bordetella avium and Bordetella bronchiseptica isolates. Antimicrob Agents Chemother. 1989 May;33(5):771–772. [PMC free article] [PubMed]
  • Nagano H, Nakai T, Horiguchi Y, Kume K. Isolation and characterization of mutant strains of Bordetella bronchiseptica lacking dermonecrotic toxin-producing ability. J Clin Microbiol. 1988 Oct;26(10):1983–1987. [PMC free article] [PubMed]
  • Nakagawa M, Nakayama K, Saito M, Takayama S, Watarai S. Bacteriological and serological studies on Pasteurella multocida infection in rabbits. Jikken Dobutsu. 1986 Oct;35(4):463–469. [PubMed]
  • Nakai T, Kume K, Yoshikawa H, Oyamada T, Yoshikawa T. Changes in the nasal mucosa of specific-pathogen-free neonatal pigs infected with Pasteurella multocida or Bordetella bronchiseptica. Nihon Juigaku Zasshi. 1986 Aug;48(4):693–701. [PubMed]
  • Nakai T, Kume K, Yoshikawa H, Oyamada T, Yoshikawa T. Adherence of Pasteurella multocida or Bordetella bronchiseptica to the swine nasal epithelial cell in vitro. Infect Immun. 1988 Jan;56(1):234–240. [PMC free article] [PubMed]
  • Nakai T, Sawata A, Kume K. Intracellular locations of dermonecrotic toxins in Pasteurella multocida and in Bordetella bronchiseptica. Am J Vet Res. 1985 Apr;46(4):870–874. [PubMed]
  • Nakai T, Sawata A, Tsuji M, Samejima Y, Kume K. Purification of dermonecrotic toxin from a sonic extract of Pasteurella multocida SP-72 serotype D. Infect Immun. 1984 Nov;46(2):429–434. [PMC free article] [PubMed]
  • NEIMARK FM, LUGOVAIA LV, BELOVA ND. [Parapertussis bacillus and its significance in whooping cough]. Zh Mikrobiol Epidemiol Immunobiol. 1961 Aug;32:49–53. [PubMed]
  • Oyamada T, Yoshikawa T, Yoshikawa H, Shimizu M, Nakai T, Kume K. Lesions induced in the nasal turbinates of neonatal pigs inoculated with Pasteurella multocia and/or Bordetella bronchiseptica. Nihon Juigaku Zasshi. 1986 Apr;48(2):377–387. [PubMed]
  • Papasian CJ, Downs NJ, Talley RL, Romberger DJ, Hodges GR. Bordetella bronchiseptica bronchitis. J Clin Microbiol. 1987 Mar;25(3):575–577. [PMC free article] [PubMed]
  • Pedersen KB, Barfod K. Effect of vaccination of sows with Bordetella bronchiseptica on the incidence of atrophic rhinitis in swine. Nord Vet Med. 1977 Sep;29(9):369–375. [PubMed]
  • Pedersen KB, Barfod K. The aetiological significance of Bordetella bronchiseptica and Pasteurella multocida in atrophic rhinitis of swine. Nord Vet Med. 1981 Dec;33(12):513–522. [PubMed]
  • Pedersen KB, Barfod K. Effect on the incidence of atrophic rhinitis of vaccination of sows with a vaccine containing Pasteurella multocida toxin. Nord Vet Med. 1982 Jul-Sep;34(7-9):293–302. [PubMed]
  • Pedersen MM, Marso E, Pickett MJ. Nonfermentative bacilli associated with man. 3. Pathogenicity and antibiotic susceptibility. Am J Clin Pathol. 1970 Aug;54(2):178–192. [PubMed]
  • Pickett MJ, Greenwood JR. Identification of oxidase-positive, glucose-negative, motile species of nonfermentative bacilli. J Clin Microbiol. 1986 May;23(5):920–923. [PMC free article] [PubMed]
  • Pickett MJ, Manclark CR. Nonfermentative bacilli associated with man. I. Nomenclature. Am J Clin Pathol. 1970 Aug;54(2):155–163. [PubMed]
  • Pijpers A, Van Klingeren B, Schoevers EJ, Verheijden JH, Van Miert AS. In vitro activity of five tetracyclines and some other antimicrobial agents against four porcine respiratory tract pathogens. J Vet Pharmacol Ther. 1989 Sep;12(3):267–276. [PubMed]
  • Regan J, Lowe F. Enrichment medium for the isolation of Bordetella. J Clin Microbiol. 1977 Sep;6(3):303–309. [PMC free article] [PubMed]
  • Rhodes MB, New CW, Jr, Baker PK, Hogg A, Underdahl NR. Bordetella bronchiseptica and toxigenic type D Pasteurella multocida as agents of severe atrophic rhinitis of swine. Vet Microbiol. 1987 Feb;13(2):179–187. [PubMed]
  • Roop RM, 2nd, Veit HP, Sinsky RJ, Veit SP, Hewlett EL, Kornegay ET. Virulence factors of Bordetella bronchiseptica associated with the production of infectious atrophic rhinitis and pneumonia in experimentally infected neonatal swine. Infect Immun. 1987 Jan;55(1):217–222. [PMC free article] [PubMed]
  • Ross RF, Switzer WP, Duncan JR. Comparison of pathogenicity of various isolates of Bordetella bronchiseptica in young pigs. Can J Comp Med Vet Sci. 1967 Feb;31(2):53–57. [PMC free article] [PubMed]
  • Runnels LJ. Infectious atrophic rhinitis of swine. Vet Clin North Am Large Anim Pract. 1982 Nov;4(2):301–319. [PubMed]
  • Rutter JM. Quantitative observations on Bordetella bronchiseptica infection in atrophic rhinitis of pigs. Vet Rec. 1981 May 23;108(21):451–454. [PubMed]
  • Rutter JM. Virulence of Pasteurella multocida in atrophic rhinitis of gnotobiotic pigs infected with Bordetella bronchiseptica. Res Vet Sci. 1983 May;34(3):287–295. [PubMed]
  • Rutter JM, Francis LM, Sansom BF. Virulence of Bordetella bronchiseptica from pigs with or without atrophic rhinitis. J Med Microbiol. 1982 Feb;15(1):105–116. [PubMed]
  • Rutter JM, Mackenzie A. Pathogenesis of atrophic rhinitis in pigs: a new perspective. Vet Rec. 1984 Jan 28;114(4):89–90. [PubMed]
  • Sawata A, Nakai T, Tuji M, Kume K. Dermonecrotic activity of Pasteurella multocida strains isolated from pigs in Japanese field. Nihon Juigaku Zasshi. 1984 Apr;46(2):141–148. [PubMed]
  • Stoll DB, Murphey SA, Ballas SK. Bordetella bronchiseptica infection in stage IV Hodgkin's disease. Postgrad Med J. 1981 Nov;57(673):723–724. [PMC free article] [PubMed]
  • Strandberg DA, Jorgensen JH, Drutz DJ. Activities of aztreonam and new cephalosporins against infrequently isolated gram-negative bacilli. Antimicrob Agents Chemother. 1983 Aug;24(2):282–286. [PMC free article] [PubMed]
  • Switzer WP, Maré CJ, Hubbard ED. Incidence of Bordetella bronchiseptica in wildlife and man in iowa. Am J Vet Res. 1966 Jul;27(119):1134–1136. [PubMed]
  • Thompson H, McCandlish IA, Wright NG. Experimental respiratory disease in dogs due to Bordetella bronchiseptica. Res Vet Sci. 1976 Jan;20(1):16–23. [PubMed]
  • Tuomanen EI, Nedelman J, Hendley JO, Hewlett EL. Species specificity of Bordetella adherence to human and animal ciliated respiratory epithelial cells. Infect Immun. 1983 Nov;42(2):692–695. [PMC free article] [PubMed]
  • Wardlaw AC, Parton R. Bordetella pertussis toxins. Pharmacol Ther. 1982;19(1):1–53. [PubMed]
  • Watson WT, Goldsboro JA, Williams FP, Sueur R. Experimental respiratory infection with Pasteurella multocida and Bordetella bronchiseptica in rabbits. Lab Anim Sci. 1975 Aug;25(4):459–464. [PubMed]
  • Wright NG, Thompson H, Taylor D, Cornwell HJ. Bordetella bronchiseptica: a re-assessment of its role in canine respiratory disease. Vet Rec. 1973 Nov 3;93(18):486–487. [PubMed]

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